Article
Ophthalmology
Jae Yong Park, Min-Ji Kang, Bum Gi Kim, Kyu Ho Chung, Ha Eun Sim, Seong Woo Lee, Jae Suk Kim, Hyeon Seok Lee, Je Hyung Hwang
Summary: The study found that during the development of CNV, there is a significant increase in choroidal thickness in the corresponding subfield. Additionally, three months before the development of CNV, the choroidal thickness in the central subfield also significantly increases. Regular measurement of choroidal thickness may help in predicting CNV development.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Gideon Obasanmi, Matthew R. Zeglinski, Ella Hardie, Anna-Catharina Wilhelm, Christopher T. Turner, Sho Hiroyasu, Wendy A. Boivin, Yuan Tian, Hongyan Zhao, Eleanor To, Jing Z. Cui, Jeanne Xi, Hyung-Suk Yoo, Manjosh Uppal, David J. Granville, Joanne A. Matsubara
Summary: Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss in the elderly and is associated with abnormal blood vessel growth. This study explored the relationship between the protease Granzyme B (GzmB) and the antiangiogenic factors Thrombospondin (TSP)-1 and TSP-2 in eyes with neovascular AMD. The study found that TSP-1 and TSP-2 are substrates of GzmB and that the proteolysis of these factors by GzmB may contribute to neovascular AMD-related choroidal neovascularization (CNV).
LABORATORY INVESTIGATION
(2023)
Review
Cell Biology
Aniket Ramshekar, Haibo Wang, M. Elizabeth Hartnett
Summary: AMD is a major cause of blindness worldwide, with neovascular AMD leading to vision loss. The current standard of care with anti-angiogenic agents is only effective in around 50% of AMD cases. Studies have shown that Rac1 activation plays a crucial role in the invasion of choroidal endothelial cells into the neural retina in AMD.
Article
Endocrinology & Metabolism
Yan Gong, Yohei Tomita, Matthew L. Edin, Anli Ren, Minji Ko, Jay Yang, Edward Bull, Darryl C. Zeldin, Ann Hellstrom, Zhongjie Fu, Lois E. H. Smith
Summary: This study investigated the effects of LCPUFA metabolites through the CYP2J2 pathway and CYP2J2 regulation on CNV. The results showed that inhibiting CYP2J2 can enhance the inhibitory effect of ω-3 LCPUFA on CNV, and co-treatment with montelukast, which inhibits CYP2C8, further enhances the suppression of CNV.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Chemistry, Medicinal
Tingting Sun, Qingquan Wei, Peng Gao, Yongjie Zhang, Qing Peng
Summary: The study investigated cytokine and chemokines profiling in the aqueous humor of nAMD patients, finding lower levels of basic fibroblast growth factor and RANTES, and higher levels of VEGF-A compared to the control group. After IVR treatment, levels of Eotaxin increased while VEGF-A decreased in nAMD patients.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Multidisciplinary Sciences
Daniel Duck-Jin Hwang, Seong Choi, Junseo Ko, Jeewoo Yoon, Ji In Park, Joon Seo Hwang, Jeong Mo Han, Hak Jun Lee, Joonhong Sohn, Kyu Hyung Park, Jinyoung Han
Summary: This study successfully distinguished between RAP and PCV cases in neovascular age-related macular degeneration using a deep learning model, showing high accuracy, sensitivity, and specificity. The novel model performed well in distinguishing between PCV and RAP, demonstrating better diagnostic performance than other models and comparable performance with ophthalmologists.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
I-Chia Liang, Wen-Chin Ko, Yu-Jou Hsu, Yi-Ru Lin, Yun-Hsiang Chang, Xv-Hui Zong, Pei-Chen Lai, Der-Chen Chang, Chi-Feng Hung
Summary: The experiment demonstrated that H-2 inhalation could significantly alleviate CNV leakage in a mouse model of CNV, possibly through suppression of the inflammatory process and VEGF-driven CNV formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Jae Hui Kim, Jong Woo Kim, Chul Gu Kim
Summary: This study investigated the incidence, risk factors, and impact on visual outcomes of SRH in patients with nAMD and PCV who discontinued treatment. SRH development led to poor visual prognosis in those who stopped treatment, and type 3 MNV had a relatively high risk of SRH occurrence.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Jae-Hui Kim, Jong-Woo Kim, Chul-Gu Kim
Summary: This study revealed a trend in the selection of ranibizumab and aflibercept for initial treatment of neovascular AMD and PCV, with ranibizumab preferred in older patients and those with type 3 MNV, and aflibercept highly preferred in patients with PCV. The variance in patient characteristics and efficacy of the two agents may have influenced this trend.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Mariko Sasaki, Ryo Kawasaki, Yasuo Yanagi
Summary: The progression of age-related macular degeneration (AMD) is influenced by environmental and genetic factors. Risk factor profiles for advanced AMD vary among individuals, with ethnicity potentially playing a role. Retinal imaging technology has revealed previously unknown risk factors for advanced AMD, expanding the understanding beyond traditional imaging markers. The OCT imaging modality has identified novel pathognomonic changes for early AMD, as well as features associated with the risk of geographic atrophy and macular neovascularization (MNV), indicating that MNV may not be a single disease entity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Caijiao Yi, Jian Liu, Wen Deng, Chang Luo, Jinyan Qi, Mei Chen, Heping Xu
Summary: This study investigated the effect of ageing on subretinal fibrosis secondary to choroidal neovascularization and the mechanism of action. The results showed that ageing increased the number of circulating fibrocytes and the profibrotic potential of BM-derived macrophages. Additionally, aged mice had significantly more severe subretinal fibrosis compared to young mice. The transplantation of BM from aged mice significantly increased subretinal fibrosis in young mice.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Pharmacology & Pharmacy
Pengxiang Zhou, Siqian Zheng, Ente Wang, Peng Men, Suodi Zhai
Summary: Conbercept is well-tolerated and effective in improving vision and fundus condition in patients with neovascular age-related macular degeneration and diabetic macular edema compared with laser photocoagulation, intravitreal triamcinolone acetonide, and placebo. Further large-sample and long-term studies are needed.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mayank Choubey, Puran Bora
Summary: Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in adults, with significant visual disability and central vision loss. Adiponectin (APN) and its receptors (AdipoRs) play a central role in metabolic disorders and ocular pathology. This review summarizes the association of APN/AdipoRs with retinal diseases, specifically AMD and diabetic retinopathy, and presents original research on the inhibition of choroidal neovascularization (CNV) in a mouse model with APN-derived peptides.
Article
Chemistry, Multidisciplinary
Siva P. Kambhampati, Imran A. Bhutto, Tony Wu, Katie Ho, D. Scott McLeod, Gerard A. Lutty, Rangaramanujam M. Kannan
Summary: The study demonstrates a potential systemic therapy approach for selectively targeting and inhibiting the progression of AMD, showing promising efficacy in animal models and human postmortem studies.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Bomina Park, Sheik Pran Babu Sardar Pasha, Kamakshi L. Sishtla, Gabriella D. Hartman, Xiaoping Qi, Michael E. Boulton, Timothy W. Corson
Summary: The study validates soluble epoxide hydrolase (sEH) as a potential therapeutic target for choroidal neovascularization (CNV) associated with wet age-related macular degeneration (nAMD). Knockdown of the sEH gene significantly reduces CNV and normalizes the expression levels of CNV-related inflammatory markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Keiko Kataoka, Jun Takeuchi, Yuyako Nakano, Ai Fujita, Hiroki Kaneko, Yasuki Ito, Hiroko Terasaki
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2020)
Article
Ophthalmology
Kei Takayama, Hideaki Someya, Hiroshi Yokoyama, Takeshi Kimura, Yoshihiro Takamura, Masakazu Morioka, Seiji Sameshima, Tetsuo Ueda, Nahoko Ogata, Shigehiko Kitano, Maki Tashiro, Masahiko Sugimoto, Mineo Kondo, Taiji Sakamoto, Masaru Takeuchi
ACTA OPHTHALMOLOGICA
(2020)
Article
Endocrinology & Metabolism
Ayana Suzumura, Hiroki Kaneko, Yasuhito Funahashi, Kei Takayama, Masatoshi Nagaya, Seina Ito, Toshiaki Okuno, Toshiaki Hirakata, Norie Nonobe, Keiko Kataoka, Hideyuki Shimizu, Rina Namba, Kazuhisa Yamada, Fuxiang Ye, Yoko Ozawa, Takehiko Yokomizo, Hiroko Terasaki
Article
Ophthalmology
Toshiyuki Matsuura, Hiroki Kaneko, Kei Takayama, Rei Shibata, Keiko Kataoka, Seina Ito, Taichi Tsunekawa, Hideyuki Shimizu, Ayana Suzumura, Rina Namba, Yasuki Ito, Toyoaki Murohara, Hiroko Terasaki
Article
Ophthalmology
Hirotaka Ito, Yasuki Ito, Keiko Kataoka, Shinji Ueno, Jun Takeuchi, Yuyako Nakano, Ai Fujita, Etsuyo Horiguchi, Hiroki Kaneko, Takeshi Iwase, Hiroko Terasaki
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Kazuhisa Yamada, Hiroki Kaneko, Hideyuki Shimizu, Ayana Suzumura, Rina Namba, Kei Takayama, Seina Ito, Masataka Sugimoto, Hiroko Terasaki
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2020)
Article
Ophthalmology
Jun Takeuchi, Keiko Kataoka, Hideyuki Shimizu, Ryo Tomita, Taro Kominami, Hiroaki Ushida, Hiroki Kaneko, Yasuki Ito, Hiroko Terasaki
Summary: Autologous neurosensory retinal flap transplantation (ART) can improve the morphological and functional outcomes of high myopia-related refractory macular hole (MH), but attention should be paid to the development of choroidal neovascularization postoperatively. Microperimetry can evaluate the treatment effect.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Ayana Suzumura, Ryo Terao, Hiroki Kaneko
Article
Ophthalmology
Hiroki Kaneko, Norifumi Hirata, Hideyuki Shimizu, Keiko Kataoka, Norie Nonobe, Kumiko Mokuno, Hiroko Terasaki
Summary: This retrospective clinical study investigated the effects of internal limiting membrane (ILM) peeling on visual field sensitivities in eyes with epiretinal membrane (ERM) accompanied by glaucoma with hemifield defect and myopia. The study found that visual field sensitivity reduction mainly occurred in the nasal region of the glaucomatous hemifield, and that differences in axial length were not a prominent risk factor for reduced visual field sensitivity after ILM peeling in eyes with ERM.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Noriko Takashi, Aya Nakamura, Keiko Kataoka, Yoshihiko Usui, Yasuki Ito, Hiroki Kaneko
Summary: GPA is a rare systemic autoimmune disease that can affect ocular tissues. This case report discusses a GPA patient who developed retinal detachment after long-term steroid treatment, which was ultimately diagnosed as CSC rather than CNV. Reduction in steroid dose led to no worsening in the patient's condition.
Article
Ophthalmology
Hiroki Kaneko, Noriko Takashi, Masaaki Matsunaga, Yasuki Ito, Jun Takeuchi, Hiroko Terasaki, Hiroshi Yatsuya, Koji M. Nishiguchi
Summary: The study found that the seasonal variation in acute massive submacular hemorrhages caused by age-related macular degeneration disappeared in 2012-2019, while those caused by retinal microaneurysms emerged with significant seasonal variation.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Kei Takayama, Hideaki Someya, Hiroshi Yokoyama, Takeshi Kimura, Yoshihiro Takamura, Masakazu Morioka, Hiroto Terasaki, Tetsuo Ueda, Nahoko Ogata, Shigehiko Kitano, Maki Tashiro, Taiji Sakamoto, Masaru Takeuchi
Summary: In this study, younger age and the presence of neovascular glaucoma and tractional retinal detachment were identified as potential biases in using IVI before vitrectomy for PDR complications. Eyes that received preoperative IVI had a higher frequency of intraoperative retinal breaks requiring tamponade, but there were no significant differences in postoperative outcomes compared to eyes that did not receive IVI.
Article
Biochemistry & Molecular Biology
Hideyuki Shimizu, Kei Takayama, Kazuhisa Yamada, Ayana Suzumura, Tomohito Sato, Yoshiaki Nishio, Masataka Ito, Hiroaki Ushida, Koji M. Nishiguchi, Masaru Takeuchi, Hiroki Kaneko
Summary: The study aims to investigate the protective effect of dimethyl fumarate (DMF) against blue-light (BL) exposure in retinal pigment epithelial (RPE) cells. The results demonstrate that DMF can reduce reactive oxygen species (ROS) generation, decrease cell death rate and apoptosis in RPE cells induced by BL exposure. Additionally, DMF inhibits inflammation through activation of the NRF2 signaling pathway induced by BL exposure. Therefore, DMF has a protective effect on RPE cells against BL exposure.
Meeting Abstract
Ophthalmology
Yosuke Taki, Yasuki Ito, Jun Takeuchi, Yuyako Nakano, Etsuyo Horiguchi, Ohta Hikaru, Hiroki Kaneko, Shinji Ueno, Hiroko Terasaki, Keiko Kataoka
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Ai Fujita, Keiko Kataoka, Jun Takeuchi, Yuyako Nakano, Etsuyo Horiguchi, Hiroki Kaneko, Yasuki Ito, Hiroko Terasaki
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2020)