Article
Chemistry, Analytical
Shaoyu Kang, Mohamed Sharafeldin, Sophie C. Patrick, Xuanxiao Chen, Jason J. Davis
Summary: We present a simple method for quantifying target proteins by monitoring the redox capacitance of a conductive polymer interface. This method allows real-time analysis of both association and dissociation regimes and can detect target proteins at picomolar levels within 15 seconds. This proof-of-principle methodology is expected to be widely applicable in quantifying other clinically relevant targets.
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Donato Calabria, Elisa Lazzarini, Andrea Pace, Ilaria Trozzi, Martina Zangheri, Stefano Cinti, Marinella Difonzo, Giovanni Valenti, Massimo Guardigli, Francesco Paolucci, Mara Mirasoli
Summary: A portable, 3D-printed miniaturized electrochemiluminescence (ECL) biosensor for glucose detection has been developed using carbon black-doped polylactic acid (PLA) electrodes. The ECL emission is obtained using a 1.5V AA alkaline battery and detected with a smartphone camera, enabling easy portability. The biosensor showed excellent ability to detect glucose and can be used for point-of-care analysis by preloading the necessary reagents.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Elnaz Zeynaloo, Elsayed M. Zahran, Yu-Ping Yang, Emre Dikici, Trajen Head, Leonidas G. Bachas, Sylvia Daunert
Summary: This study introduces a new method of using unnatural amino acids as protein labels, which not only changes the local microenvironment but also has minimal impact on the overall structure. By incorporating L-DOPA into the protein, it can be used as an electrochemical label for highly selective and sensitive detection of glucose.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Materials Science, Textiles
Karima Sahtani, Yakup Aykut, Nilay Aladag Tanik
Summary: The use of hemoglobin-assisted carbon nanofibers for selective detection of miRNA molecules showed promising results, with an increase in guanine oxidation signal levels observed. This enhanced signal level could be attributed to the catalytic effect of low hemoglobin addition during the carbonization process, leading to a higher graphitic level in the precursor nanofibers. The biosensory system developed could be utilized for the selective detection of miRNA molecules.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Article
Biophysics
Jose M. R. Flauzino, Emily P. Nguyen, Qiuyue Yang, Giulio Rosati, David Panacek, Ana G. Brito-Madurro, Joao M. Madurro, Aristides Bakandritsos, Michal Otyepka, Arben Merkoci
Summary: This study presents a label-free impedimetric genosensor for the sensitive detection of pork residues in meat, utilizing the biosensing capabilities of graphene acid. The sensor can detect pork residues in beef in less than 45 minutes, with a detection limit of 9%.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemical Research Methods
Baban Dey, Md. Wasi Ahmad, Bo Hye Kim, Tahseen Kamal, Duck-Joo Yang, Chandra N. Patra, S. K. Safdar Hossain, Arup Choudhury
Summary: In this study, a hybrid array based on manganese cobalt (2-methylimodazole)-metal organic frameworks (Mn-Co(2-MeIm)MOF) and carbon nanofibers (CNFs) was prepared as a non-enzymatic electrochemical sensor for histamine detection in fish and bananas. The hybrid array exhibited high porosity, large specific surface area, and excellent hydrophilicity, enabling easy access of analyte molecules to the redox-active metal sites of the MOF. The sensor demonstrated excellent electrocatalytic activity for histamine oxidation under acidic conditions, with a wide linear range, low limit of detection, and high sensitivity. Importantly, the sensor was capable of detecting histamine in fish and banana samples stored for different periods of time, indicating its practical viability as an analytical histamine detector.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Irem Okman Kocoglu, Pinar Esra Erden, Esma Kilic
Summary: In this study, an electrochemical biosensor based on carbon nanofibers and ionic liquid modification was constructed for tyramine detection. The biosensor showed linear response, low detection limit, high sensitivity, and exhibited good reproducibility, stability, and anti-interference ability.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Chemistry, Analytical
Laura Sakalauskiene, Benediktas Brasiunas, Anton Popov, Asta Kausaite-Minkstimiene, Almira Ramanaviciene
Summary: The development of a first-generation reagentless amperometric glucose biosensor based on the combination of AuNS, PB, and GOx has been achieved, enabling convenient and intuitive glucose detection. The biosensor exhibits a wide linear range, good repeatability, and high selectivity.
Article
Engineering, Environmental
Jiaqi Zhang, Christopher Hurren, Zhentan Lu, Dong Wang
Summary: This research presents a simple nanofiber-based platform for highly sensitive colorimetric/fluorometric detection of Escherichia coli (E. coli) in complex environmental samples. The nanofiber membranes loaded with target molecules via chemical modification can produce biological signals and color change triggered by beta-glucuronidase secreted by E. coli. The nanofiber-based platforms exhibited high stability, a wide detection range, high specificity, and low interference, making them promising for environmental and food safety testing. The combination with a smartphone app enables on-site detection of E. coli.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Electrochemistry
Hamza Abdalla Yones, Lin Zhu, Bo Shao, Siyue Zhang, Hui Xie, Xiaoqing Li, Wei Sun
Summary: A MgO@CNFs nanocomposite was prepared and casted onto a carbon ionic liquid electrode, with hemoglobin immobilized by a Nafion polymer film. The modified electrode provided a favorable microenvironment for Hb, improving loading amount and electron transfer rate. The study demonstrated high electrocatalytic activity for the reduction of trichloroacetic acid, offering a novel approach for nanostructured biosurfaces in electrochemical biosensors.
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2021)
Article
Chemistry, Analytical
Nataliya Stasyuk, Andriy Zakalskiy, Wojciech Nogala, Sylwester Gawinkowski, Tomasz Ratajczyk, Magdalena Bonarowska, Olha Demkiv, Oksana Zakalska, Mykhailo Gonchar
Summary: This paper presents a novel bioelectrode for the direct measurement of creatinine, which overcomes the issue of high working potential in current creatinine-selective biosensors by using electrocatalytic nanocomposites that work at low potentials. The bioelectrode exhibits sufficient sensitivity, a broad linear range, a low limit of detection, and excellent selectivity towards creatinine.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Chemistry, Multidisciplinary
Yutong Du, Xinyi Zhang, Ping Liu, Deng-Guang Yu, Ruiliang Ge
Summary: This article reviews the applications of glucose sensors based on electrospun nanofibers. The principles, detection methods, and advantages of glucose sensors are discussed. The enzymatic and non-enzymatic nanofiber-based glucose sensors are compared and evaluated, and potential solutions are proposed.
FRONTIERS IN CHEMISTRY
(2022)
Article
Engineering, Multidisciplinary
Ramdayal Yadav, Omid Zabihi, Sobhan Fakhrhoseini, Hossein Ajdar Nazarloo, Alper Kiziltas, Patrick Blanchard, Minoo Naebe
Summary: Concerns over unsustainable technology-driven economies, environmental threats, and the continuous reduction of petroleum feedstocks have led to the exploration of green and naturally available resources. Lignin, a highly abundant material, shows promise as a sustainable alternative for producing carbon fiber, which is typically derived from expensive and unsustainable precursors. This review discusses the manufacturing process and applications of lignin-derived carbon fiber and highlights the challenges that need to be overcome for its wider industrialization.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Energy & Fuels
Gyawali Ghanashyam, Hae Kyung Jeong
Summary: By utilizing ambient plasma treatment, the surface area of carbon nanofiber is increased threefold and the electrochemical charge-transfer resistance is significantly decreased, resulting in materials suitable for flexible supercapacitor applications with high specific energy and power, reliable flexibility, and excellent cycling stability.
JOURNAL OF ENERGY STORAGE
(2021)
Article
Chemistry, Physical
John Tianci Li, Kevin M. Wyss, Weiyin Chen, Jinhang Chen, Bing Deng, Jacob L. Beckham, Paul A. Advincula, Paul E. Savas, Victor Desheng Li, Oceana Jin, James M. Tour
Summary: We report the synthesis of laser-induced glassy carbon nanofiber trees (CNFT). Unlike previous laser-induced graphene (LIG) and laser-induced graphene fibers (LIGF), the CNFT do not possess a highly graphenized nanostructure. The formation of CNFT involves conditions that usually remove the carbon precursors, leading to their recent discovery as a laser-induced carbon nanomaterial. We demonstrated the application of CNFT as a promising energy storage material by testing it as an electrode material for anode-free lithium metal batteries, showing low overpotential, small nucleation energy barrier, and good cycling stability.
Article
Chemistry, Multidisciplinary
Rosemary K. Le, Maryam Raeeszadeh-Sarmazdeh, Eric T. Boder, Paul D. Frymier
Article
Chemistry, Physical
Bradley J. Harris, Xiaolin Cheng, Paul Frymier
JOURNAL OF PHYSICAL CHEMISTRY B
(2016)
Article
Plant Sciences
Khoa Nguyen, Michael Vaughn, Paul Frymier, Barry D. Bruce
PHOTOSYNTHESIS RESEARCH
(2017)
Article
Green & Sustainable Science & Technology
Bruce Tonn, Paul D. Frymier, Dorian Stiefel, Leah Soro Skinner, Nethika Suraweera, Rachel Tuck
JOURNAL OF CLEANER PRODUCTION
(2014)
Article
Chemistry, Physical
Bradley J. Harris, Xiaolin Cheng, Paul Frymier
JOURNAL OF PHYSICAL CHEMISTRY B
(2014)
Article
Multidisciplinary Sciences
Sandra M. Davern, Timothy E. McKnight, Robert F. Standaert, Jennifer L. Morrell-Falvey, Elena D. Shpak, Udaya C. Kalluri, Joanna Jelenska, Jean T. Greenberg, Saed Mirzadeh
Article
Nanoscience & Nanotechnology
A. Kodumagulla, V. Varanasi, R. C. Pearce, W. C. Wu, D. K. Hensley, J. B. Tracy, T. E. McKnight, A. V. Melechko
NANOMATERIALS AND NANOTECHNOLOGY
(2014)
Article
Multidisciplinary Sciences
Justin S. Baba, Timothy E. McKnight, M. Nance Ericson, Anthony Johnson, Kenneth J. Moise, Boyd M. Evans
Article
Biophysics
Samantha T. Clark, Matthias M. L. Arras, Stephen A. Sarles, Paul D. Frymier
Summary: This study investigates the association of a small molecule with two different membrane types by modeling and experimentally observing the association of detergent Triton X-100 with egg phosphatidylcholine (ePC) liposomes and egg phosphatidic acid (ePA) liposomes at varying ratios. A saturation model was developed to predict the association of detergent with each liposome type when lipid bilayers are fully saturated, based on the detergent to lipid ratio and relative absorbance intensity for each pure liposome species at saturation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Michael W. Ambrogio, Miguel Toro-Gonzale, Tamara J. Keever, Timothy E. McKnight, Sandra M. Davern
ACS APPLIED NANO MATERIALS
(2020)
Review
Biochemistry & Molecular Biology
Baker A. Martin, Paul D. Frymier
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2017)
Meeting Abstract
Chemistry, Multidisciplinary
Sarah Williamson, Leah Parks, Rosemary Le, Maryam Raeeszadeh Sarmazdeh, Paul Frymier, Eric Boder
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Meeting Abstract
Chemistry, Multidisciplinary
Bradley J. Harris, Rosemary K. Le, Paul D. Frymier
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Meeting Abstract
Chemistry, Multidisciplinary
Rosemary Le, Paul Frymier
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Article
Materials Science, Multidisciplinary
Ryan Pearce, Timothy McKnight, Kate L. Klein, Ilia N. Ivanov, Dale Hensley, Harry Meyer, Anatoli Melechko
AIMS MATERIALS SCIENCE
(2014)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
