Review
Materials Science, Multidisciplinary
He Ma, Song Wang, Bing Yu, Xin Sui, Youqing Shen, Hailin Cong
Summary: Bio-nanochannels in living organisms selectively transport ions through cell membranes and inspire the development of artificial ion nanochannels. Polymer-based biomimetic nanochannels offer good mechanical stability, high-performance ion transport, and designability. This review mainly focuses on the fabrication and application of polymer-based biomimetic nanochannels, especially in environmentally responsive biosensor and energy conversion.
SCIENCE CHINA-MATERIALS
(2021)
Article
Biophysics
Paola Piedimonte, Laura Sola, Marina Cretich, Alessandro Gori, Marcella Chiari, Edoardo Marchisio, Piero Borga, Riccardo Bertacco, Andrea Melloni, Giorgio Ferrari, Marco Sampietro
Summary: We have developed a biosensing system that can detect viruses through serological analysis based on impedance variation. The system has high sensitivity and can be easily adapted to different pathogens and diseases.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Biomedical
Mingyang Li, Ninglong Zhang, Zhiyong Cui, Wenli Wang, Cunli Wang, Dongdong Wang, Minmin Li, Wenqi Lu, Guangyan Qing, Yuan Liu
Summary: This study presents a biomimetic nanochannel system integrated with the Venus flytrap domain from the human umami receptor, which can accurately distinguish umami substances. Mechanism analysis reveals that specific binding triggers conformational changes and surface charge redistribution, modulating ionic current.
Article
Chemistry, Multidisciplinary
Peng Xue, Mi Qu, Jie Shi, Youhong Jiang, Nana He, Tiqing Zhao, Shiwen Luo, Jia-Jun Zhang, Shiyuan Zhou, Yong Luo, Guangwen Chu, Hui Li, Jian-Feng Chen, Shi-Gang Sun, Hong-Gang Liao
Summary: This study used liquid cell transmission electron microscopy (TEM) to directly track the migration of microfluidic units at the nanoscale. An unexpected mass transfer phenomenon was discovered, where fluid units in the stagnant liquid layer migrated two orders faster during gas-liquid interface updating. Molecular dynamics simulations showed that the chemical potential difference between nanoscale liquid layers led to convective flow, greatly enhancing mass transfer on the surface.
Article
Engineering, Chemical
Seung Eun Lee, Kyoung-Yong Chun, Jongwoon Kim, Sunghwan Jo, Chang -Soo Han
Summary: The fabrication of advanced membranes with simultaneously high electron and proton conductivities has been achieved through the thermal reduction and vertical confinement of graphene oxide (GO) channels. The improvement in electron conductivity is due to the removal of oxygen functional groups, while the extremely reduced channel size allows for selective proton transport and improved proton selectivity.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Virology
Juraina Abd-Jamil, Noor-Syahida Azizan, Nurul-Asma-Anati Che-Mat-Seri, Che-Norainon Yaacob, Nur-Izyan Samsudin, Nur-Hidayana Mahfodz, Mulya-Mustika-Sari Zulkifli, Hooi-Sim Poh, Boon-Teong Teoh, Sazaly AbuBakar
Summary: The study showed that the implementation of dengue NS1-antigen rapid diagnostic test did not affect the confirmation rate of dengue, and highlighted the advantage of using this method. DENV-1 was predominantly circulating in 2008, while both DENV-1 and DENV-2 were dominant in 2015. Detection of dengue virus using RT-PCR remains a viable option for further confirmation of dengue in hospital settings, especially with the reducing cost of molecular detection tools.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Chemistry, Analytical
Bo Lin, Jianan Hui, Hongju Mao
Summary: Nanopore technology has become increasingly important in the field of life science and biomedical research, particularly in gene sequencing and biomolecular studies, showing promising applications in cancer diagnosis, virus detection, genome assembly, and other biomedical sensing fields.
Review
Biotechnology & Applied Microbiology
Yixin Xu, Xin Jiang, Yanhong Zhou, Ming Ma, Minjin Wang, Binwu Ying
Summary: This review provides a comprehensive overview of the latest development of SELEX technology and focuses on the applications of aptamer-based technologies in infectious diseases, such as targeted drug-delivery, treatments, and biosensors for diagnosing. The challenges and the future development in this field of clinical application will also be discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Wei Yi, Chuanping Zhang, Qianchun Zhang, Changbo Zhang, Yebo Lu, Lanhua Yi, Xingzhu Wang
Summary: Solid-state nanopores/nanochannels, with their high stability, tunable geometry, and controllable surface chemistry, have become an important tool for constructing biosensors. These biosensors demonstrate significant advantages in high sensitivity, high specificity, and high spatiotemporal resolution for detecting single entities due to the unique nanoconfined space-induced target enrichment effect. However, challenges such as blocking by single entities, interference from interfering substances, and low flux in the detection process limit the application of solid-state nanopores/nanochannels. This review discusses the preparation, functionalization, research progress, and novel sensing strategies in solid-state nanopore/nanochannel single-entity sensing, as well as the challenges and prospects in this field.
TOPICS IN CURRENT CHEMISTRY
(2023)
Article
Biophysics
Insu Kim, Yonghwan Kim, Sang Won Lee, Dongtak Lee, Hyo Gi Jung, Jae Won Jang, Taeha Lee, Young Kyung Yoon, Gyudo Lee, Dae Sung Yoon
Summary: In this study, erythrocyte-camouflaged biosensors (ECB) were fabricated for sensitive detection of Staphylococcus aureus-secreted alpha-hemolysin (Hla) using erythrocyte membrane (EM) extracted from human whole blood as a novel bioreceptor. The ECB showed higher sensitivity to Hla compared to major blood proteins, with signal intensities 8.8-12.7 times higher than those of the same concentration of blood proteins. Additionally, the ECB exhibited a detection limit of 1.9 ng/ml for Hla with a dynamic range of 0.0001-1 mg/ml and maintained constant sensing performance with 99.0 +/- 5.6% accuracy during 35 days of storage.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Mengya Cao, Lijun Zhang, Haoran Tang, Xia Qiu, Yongxin Li
Summary: Solid-state nanopores provide a nanoconfined space for single-molecule sensing strategy. In this study, an aptamer-functionalized nanopore was used as a sensing platform for the kinetic analysis of carcinoembryonic antigen (CEA). The results showed that this platform could be used for protein sensing and immunoassays.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Kecheng Guan, Zhaohuan Mai, Siyu Zhou, Shang Fang, Zhan Li, Ping Xu, Yu-Hsuan Chiao, Mengyang Hu, Pengfei Zhang, Guorong Xu, Keizo Nakagawa, Hideto Matsuyama
Summary: Subnanometer interlayer space in graphene oxide (GO) laminates is important for permselective membrane nanochannels. The precise control of nanochannel space and the role of confined nanochannel chemistry in selective water/ion separation are still challenging. This study used macrocyclic molecules with consistent basal plane but varying side groups to modify nanochannels in GO laminates, and demonstrated the side-group dependence of angstrom-precision tunability for channel free space and the energy barrier setting for ion transport. The study provides insights into functional-group-dependent intercalation modifications of GO laminates for structural control and nanochannel design.
Review
Chemistry, Physical
Dominik Duleba, Robert P. Johnson
Summary: This review provides an update on the current state of ion rectifying solid-state nanopore sensors, presenting the recent developments and challenges in the field. It explains the phenomenon of ion current rectification in geometrically asymmetric nanopores and the principle of sensing using these systems. In addition to conventional approaches, intriguing sensing schemes that offer a more flexible sensing approach are also discussed. Furthermore, the review offers an overview of recent efforts in amplifying ion currents and rectification, and briefly discusses future perspectives for the field.
CURRENT OPINION IN ELECTROCHEMISTRY
(2022)
Review
Chemistry, Analytical
Yawen He, Qinqin Hu, Samantha San, Tom Kasputis, Maria Gabriella Duarte Splinter, Kun Yin, Juhong Chen
Summary: This review highlights the recent advancements in CRISPR-based biosensors for infectious disease detection, discussing their advantages, applications, and design strategies. The article identifies current challenges in the field of human health and provides future perspectives for developing more effective CRISPR-based biosensors.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Chao Wang, Mei Liu, Zhifei Wang, Song Li, Yan Deng, Nongyue He
Summary: The COVID-19 pandemic has highlighted the importance of developing point-of-care (POC) diagnostics, which offer advantages such as faster diagnostic speed, lower cost, and higher efficiency. Development of POC detection methods and devices using microfluidics, MEMS technology, nanotechnology and materials science is key to providing timely prevention and control of infectious diseases.
