Application of Optical Biosensors in Small-Molecule Screening Activities

Fragment screening to predict druggability (ligandability) and lead discovery success

(2011) Fredrik N.B. Edfeldt et al.   DRUG DISCOVERY TODAY

Kinetic efficiency: the missing metric for enhancing compound quality?

(2011) Geoffrey A. Holdgate et al.   DRUG DISCOVERY TODAY

Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands

(2010) Kim Retra et al.   ANALYTICAL BIOCHEMISTRY

Biacore analysis with stabilized G-protein-coupled receptors

(2010) Rebecca L. Rich et al.   ANALYTICAL BIOCHEMISTRY

Affinity-based, biophysical methods to detect and analyze ligand binding to recombinant proteins: Matching high information content with high throughput

(2010) Geoff A. Holdgate et al.   JOURNAL OF STRUCTURAL BIOLOGY

Fragment Library Screening and Lead Characterization Using SPR Biosensors

(2009) U. Danielson   CURRENT TOPICS IN MEDICINAL CHEMISTRY

NMR methods in fragment screening: theory and a comparison with other biophysical techniques

(2009) Claudio Dalvit   DRUG DISCOVERY TODAY

A 100K well screen for a muscarinic receptor using the Epic®label-free system – a reflection on the benefits of the label-free approach to screening seven-transmembrane receptors

(2009) K. Dodgson et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Adding calorimetric data to decision making in lead discovery: a hot tip

(2009) John E. Ladbury et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

(2008) Helena Nordström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Surface Plasmon Resonance Based Assay for the Detection and Characterization of Promiscuous Inhibitors

(2008) Anthony M. Giannetti et al.   JOURNAL OF MEDICINAL CHEMISTRY