期刊
SENSORS
卷 12, 期 9, 页码 11922-11932出版社
MDPI
DOI: 10.3390/s120911922
关键词
nanosensor; optode; histamine; in vivo
资金
- DARPA [W911NF-11-1-0025]
- National Institute of General Medicine of the National Institutes of Health [R01 GM084366]
In this communication we discuss the development of ionophore based nanosensors for the detection and monitoring of histamine levels in vivo. This approach is based on the use of an amine-reactive, broad spectrum ionophore which is capable of recognizing and binding to histamine. We pair this ionophore with our already established nanosensor platform, and demonstrate in vitro and in vivo monitoring of histamine levels. This approach enables capturing rapid kinetics of histamine after injection, which are more difficult to measure with standard approaches such as blood sampling, especially on small research models. The coupling together of in vivo nanosensors with ionophores such as nonactin provide a way to generate nanosensors for novel targets without the difficult process of designing and synthesizing novel ionophores.
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