期刊
SENSORS
卷 8, 期 10, 页码 6605-6641出版社
MDPI
DOI: 10.3390/s8106605
关键词
Molecular recognition; specific interaction; biosensor; nanopatterning; nanomaterial
资金
- Korea Foundation for International Cooperation of Science & Technology (KICOS) through a grant provided by the Korean Ministry of Science and Technology (MOST) [2007-00338]
- Korean Government (MOEHRD) [KRF-2005-005-J11903]
- SRC program (Center for Nanotubes and Nanostructured Composites) of Ministry of Science and Technology of Korea/Korea Science and Engineering Foundation
Molecular recognition and specific interactions are reliable and versatile routes for site-specific and well-oriented immobilization of functional biomolecules on surfaces. The control of surface properties via the molecular recognition and specific interactions at the nanoscale is a key element for the nanofabrication of biosensors with high sensitivity and specificity. This review intends to provide a comprehensive understanding of the molecular recognition- and specific interaction-mediated biosensor fabrication routes that leads to biosensors with well-ordered and controlled structures on both nanopatterned surfaces and nanomaterials. Herein self-assembly of the biomolecules via the molecular recognition and specific interactions on nanoscaled surfaces as well as nanofabrication techniques of the biomolecules for biosensor architecture are discussed. We also describe the detection of molecular recognition- and specific interaction-mediated molecular binding as well as advantages of nanoscale detection.
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