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Chemistry, Analytical
Yolande Christelle Ketchanji Mougang, Laurent-Mireille Endale Mangamba, Rosamaria Capuano, Fausto Ciccacci, Alexandro Catini, Roberto Paolesse, Hugo Bertrand Mbatchou Ngahane, Leonardo Palombi, Corrado Di Natale
Summary: Tuberculosis is a common cause of death in many countries, and the current diagnostic method of smear microscopy has a low true positive rate. Analyzing exhaled VOCs using sensors has been proposed as a promising alternative for disease diagnosis. Testing an electronic nose based on sensor technology in a Cameroon hospital showed promising results for the diagnosis of pulmonary TB.
Article
Chemistry, Analytical
Anna Paleczek, Dominik Grochala, Artur Rydosz
Summary: Exhaled breath analysis has gained popularity as a supplementary tool for medical diagnosis, leading researchers to develop new algorithms for data interpretation. This paper introduces a system for analyzing exhaled air with sensors and presents the XGBoost algorithm for diabetes detection. Results demonstrate that the XGBoost algorithm is highly selective and performs better than other commonly used algorithms.
Article
Food Science & Technology
Ning Yuan, Xuelu Chi, Qiaoyan Ye, Huimin Liu, Nan Zheng
Summary: We investigated the influence of heat treatment on the volatile organic compounds (VOCs) of milk using various technologies. The results showed that heat treatment at 65 degrees C for 30 min preserved the original taste of milk, while treatment at 135 degrees C significantly altered the overall flavor. Different processing techniques also affected taste presentation, with the sweetness, saltiness, and bitterness of the milk being influenced by the temperature of the heat treatment. Additionally, the composition of VOCs in milk changed with heat treatment, with acid compounds decreasing and ketones, esters, and hydrocarbons increasing. Our study provides new evidence for understanding the impact of processing on milk VOCs and insights into quality control during milk production.
Article
Chemistry, Analytical
Bei Liu, Huiqing Yu, Xiaoping Zeng, Dan Zhang, Juan Gong, Ling Tian, Junhui Qian, Leilei Zhao, Shuya Zhang, Ran Liu
Summary: This research aimed to differentiate lung cancer patients by analyzing VOCs through an E-nose platform, with 87 subjects enrolled for data collection. A sparse group feature selection method was applied to improve classification performance significantly, while statistical analysis showed that age and smoking habit had no significant influences on classification results.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Instruments & Instrumentation
V. R. Nidheesh, Aswini Kumar Mohapatra, V. K. Unnikrishnan, Rajeev Kumar Sinha, Rajesh Nayak, Vasudevan Baskaran Kartha, Santhosh Chidangil
Summary: Exhaled breath contains a variety of VOCs that can provide valuable information about health status. Analysis and detection of these VOCs at low levels in breath can be correlated with certain diseases and serve as biomarkers for ailments, with potential applications in disease screening and early detection.
APPLIED SPECTROSCOPY REVIEWS
(2021)
Article
Chemistry, Analytical
Shaoqing Cui, Lin Cao, Nuris Acosta, Heping Zhu, Peter P. Ling
Summary: The study developed an E-nose system for fast diagnosis of whitefly infestation in tomato plants, successfully determining VOC profile changes and accurately distinguishing infested plants from healthy ones. The system showed high sensitivity and capability to differentiate between whitefly-infested plants and mechanically damaged plants, offering a new method for disease detection.
Review
Biochemistry & Molecular Biology
Valentina Vassilenko, Pedro Catalao Moura, Maria Raposo
Summary: The assessment of volatile breath biomarkers has gained significant attention in the scientific and medical communities for its potential in accurately diagnosing diseases in a painless and non-invasive manner. This paper reviews relevant literature sources and identifies volatile organic compounds (VOCs) that have been identified as potential cancer biomarkers. It also discusses future trends in using volatile breath biomarkers for the detection of other forms of cancer. The future of this diagnostic tool relies on the development of more advanced collection and analysis techniques, as well as certification for its utilization in real clinical settings.
Article
Medicine, General & Internal
Carmen Bax, Stefano Robbiani, Emanuela Zannin, Laura Capelli, Christian Ratti, Simone Bonetti, Luca Novelli, Federico Raimondi, Fabiano Di Marco, Raffaele L. Dellaca
Summary: A novel sampling system was developed for analyzing exhaled breath in respiratory failure patients, showing good tolerance and successful discrimination by support vector machine between respiratory failure patients and controls.
Article
Chemistry, Analytical
Roberta Anzivino, Pasqua Irene Sciancalepore, Silvano Dragonieri, Vitaliano Nicola Quaranta, Paolo Petrone, Domenico Petrone, Nicola Quaranta, Giovanna Elisiana Carpagnano
Summary: The aim of this study was to assess the ability of a polymer-based e-nose to accurately distinguish head and neck cancer patients, healthy controls, and patients with allergic rhinitis. The results showed that the e-nose was able to differentiate between these three groups, suggesting its potential as a diagnostic tool for head and neck cancer. It is a user-friendly, fast, non-invasive, and cost-effective technology.
Review
Chemistry, Analytical
Chuntae Kim, Iruthayapandi Selestin Raja, Jong-Min Lee, Jong Ho Lee, Moon Sung Kang, Seok Hyun Lee, Jin-Woo Oh, Dong-Wook Han
Summary: This review discusses the importance of artificial olfactory systems in fields such as healthcare, along with the trend and prospects of using these systems for disease diagnosis. Monitoring health status and early disease diagnosis are crucial in modern healthcare, with the potential to increase survival rates and reduce treatment costs. The article introduces promising technologies for real-time monitoring of health conditions and early disease diagnosis through analysis of exhaled human breath.
Review
Biochemistry & Molecular Biology
Pedro Catala Moura, Moura Maria Raposo, Valentina Vassilenko
Summary: The normal and abnormal/pathological status of physiological processes in the human organism can be characterized through Volatile Organic Compounds (VOCs) emitted in breath. These compounds have been recognized as valuable biomarkers for the rapid, accurate, non-invasive, and painless diagnosis of various diseases and health conditions. This study reviews the most promising results in the field of breath biomarkers and the common methods of detecting VOCs, while also providing a database of compounds for 16 different pathologies.
BIOMEDICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Noor UA. Nazir, Shah R. Abbas
Summary: According to WHO, hepatocellular cancer (HCC) is the second leading cause of death and its incidence is increasing. This study identifies significant volatile organic compounds (VOCs) in the breath of HCC patients, particularly phenol 2,2 methylene bis [6-(1,1-dimethyl ethyl)-4-methyl] (MBMBP), which has a minimum concentration of 2100 ppm. Using thiol-modified AuNPs, the researchers developed a biosensor for detecting MBMBP in HCC breath samples, with a LOD of 0.005 molL 1. This study highlights the potential of using the biosensor for early-stage detection of HCC.
ANALYTICA CHIMICA ACTA
(2023)
Article
Medicine, General & Internal
Thanikan Sukaram, Terapap Apiparakoon, Thodsawit Tiyarattanachai, Darlene Ariyaskul, Kittipat Kulkraisri, Sanparith Marukatat, Rungsun Rerknimitr, Roongruedee Chaiteerakij
Summary: This study investigated the potential of volatile organic compounds (VOCs) as biomarkers for hepatocellular carcinoma (HCC) diagnosis and treatment monitoring. The combination of 9 VOCs showed promising sensitivity, specificity, and accuracy for HCC diagnosis. Acetone dimer had a better performance than alpha-fetoprotein (AFP) in differentiating early HCC from cirrhotic patients. Isopropyl alcohol was found to be associated with the survival of HCC patients. VOC analysis offers a feasible noninvasive approach for diagnosing and monitoring HCC.
Article
Biochemical Research Methods
A. R. Ettema, M. W. P. M. Lenders, J. Vliegen, A. Slettenaar, M. C. Tjepkema-Cloostermans, C. C. de Vos
Summary: The study found that the Aeonose(TM) could distinguish between multiple sclerosis patients and healthy control subjects with moderate sensitivity and specificity, potentially offering a quick screening test. Further research is needed to determine its ability to differentiate new MS patients and non-diagnosed subjects.
JOURNAL OF BREATH RESEARCH
(2021)
Article
Medicine, General & Internal
Renelle Myers, Dorota M. Ruszkiewicz, Austin Meister, Crista Bartolomeu, Sukhinder Atkar-Khattra, C. L. Paul Thomas, Stephen Lam
Summary: This study aimed to develop a point-of-care breath test for detecting infected individuals with mild symptoms by identifying volatile organic compounds (VOCs) common to different variants of the SARS-CoV-2 virus. The results showed that VOCs in exhaled breath could distinguish active infection from recovery/convalescence period with high accuracy and sensitivity.
Article
Biochemistry & Molecular Biology
Chunsheng Wu, Liping Du, Di Wang, Le Wang, Luhang Zhao, Ping Wang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2011)
Article
Biophysics
Chunsheng Wu, Liping Du, Di Wang, Luhang Zhao, Ping Wang
BIOSENSORS & BIOELECTRONICS
(2012)
Article
Anesthesiology
X. Chen, X. L. Zhang, L. Liu, Y. Chen, M. Y. Piao, F. J. Zhang, W. D. Wu, Y. B. Zhong, K. Sun, Y. C. Zou, X. Zhang, D. Wang, P. Wang, M. Yan
BRITISH JOURNAL OF ANAESTHESIA
(2014)
Article
Oncology
Yishan Wang, Yanjie Hu, Di Wang, Kai Yu, Ling Wang, Yingchang Zou, Cong Zhao, Xuanlang Zhang, Ping Wang, Kejing Ying
Article
Optics
Di Wang, Kai Yu, Yishan Wang, Yanjie Hu, Cong Zhao, Lin Wang, Kejing Ying, Ping Wang
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
(2012)