Article
Pharmacology & Pharmacy
Hojun Choi, Myung-Yoon Kim, Dae-Hwan Kim, Hanoul Yun, Byung-Koo Oh, Su-Bin Kim, In-Ho Song, Hyun-Soo Park, Sang-Eun Kim, Cheolhyoung Park, Chulhee Choi
Summary: This study assessed the biodistribution and pharmacokinetics of therapeutic exosomes labeled with Zr-89 in mice and rats. The results showed that the exosomes were mainly distributed in the liver and spleen, with substantial uptake by parenchymal cells. They were also moderately distributed in the kidney, lung, stomach, intestine, urinary bladder, brain, and heart. Exosomes were rapidly cleared from circulation, indicating their rapid uptake by cells and tissues.
Article
Radiology, Nuclear Medicine & Medical Imaging
Freba Grawe, Franziska Blom, Michael Winkelmann, Caroline Burgard, Christine Schmid-Tannwald, Lena M. Unterrainer, Gabriel T. Sheikh, Paulo L. Pfitzinger, Philipp Kazmierczak, Clemens C. Cyran, Jens Ricke, Christian G. Stief, Peter Bartenstein, Johannes Ruebenthaler, Matthias P. Fabritius, Thomas Geyer
Summary: PSMA-RADS 1.0 is a reliable method for assessing PSMA-PET/CT with strong consistency and agreement among readers. It shows great potential for establishing a standard approach to diagnosing and planning treatment for prostate cancer patients, and can be used confidently even by readers with less experience.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Freba Grawe, Ricarda Ebner, Thomas Geyer, Leonie Beyer, Michael Winkelmann, Gabriel T. Sheikh, Ralf Eschbach, Christine Schmid-Tannwald, Clemens C. Cyran, Jens Ricke, Peter Bartenstein, Maurice M. Heimer, Lorenzo Faggioni, Christine Spitzweg, Matthias P. Fabritius, Christoph J. Auernhammer, Johannes Ruebenthaler
Summary: This study aimed to determine the intra- and interreader agreement of SSTR-RADS 1.0. The results showed high consistency among readers in assessing target lesions using SSTR-RADS 1.0, indicating that the system can effectively standardize the diagnosis and treatment planning in NET patients.
EUROPEAN RADIOLOGY
(2023)
Review
Medicine, General & Internal
Jin A. Mo
Summary: This study conducted a pooled analysis on the diagnostic accuracy of F-18 FES PET/CT in assessing estrogen receptor expression of patients with recurrent or metastatic breast cancer. The evaluation concluded that the test is safe and effective, with high clinical utility due to its high sensitivity and specificity.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Review
Oncology
Federica Matteucci, Giovanni Paganelli, Giovanni Martinelli, Claudio Cerchione
Summary: Recent advances in the diagnosis and treatment of multiple myeloma have emphasized the importance of imaging methods, particularly PET/CT, in providing accurate information for disease localization, prognosis, and therapy response evaluation. While 18F-FDG tracer is commonly used and has high sensitivity, limitations such as physiological uptake in the bone marrow and brain have prompted research on other PET tracers for improved accuracy in multiple myeloma management.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wen Dongxiang, Liu Liting, Liang Yujing, Luo Meijuan, Guo Shanshan, Xiong Longbin, Chen Yanzhou, Chen Meiling, Ning Kang, Mai Haiqiang, Tang Linquan, Chen Qiuyan
Summary: This study found that [F-18]FDG PET/CT parameters were valuable in predicting overall survival (OS) and progression-free survival (PFS) for locally recurrent nasopharyngeal carcinoma (lrNPC) patients. The 4-factor prognostic model combining baseline patient characteristics with [F-18]FDG PET/CT parameters showed good discrimination, agreement, and potential for clinical application in lrNPC patients.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Georgios Benetos, Dominik C. Benz, Georgios P. Rampidis, Andreas A. Giannopoulos, Elia von Felten, Adam Bakula, Aleksandra Sustar, Tobias A. Fuchs, Aju P. Pazhenkottil, Catherine Gebhard, Philipp A. Kaufmann, Christoph Grani, Ronny R. Buechel
Summary: CAVi, derived from CCTA, is proposed as an indicator of diffuse atherosclerosis. This study found that CAVi is moderately correlated with stress MBF and MFR, and has incremental value in predicting abnormal stress MBF and ischemia compared to CCTA alone.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hee Sang Oh, Tae Hoon Kim, Ji Won Kim, Juyeon Yang, Hye Sun Lee, Jae-Hoon Lee, Chul Hwan Park
Summary: This study investigated the feasibility and limitations of using deep learning-based coronary calcium scoring in PET-CT compared to ECG-gated non-contrast-enhanced CaCT. Results showed that PET-CT with AI-assisted CACS measurements had comparable results to CACS in coronary calcium CT. However, there were concerns about the relatively high false-negative results and tendency to underestimate.
EUROPEAN RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Soon Ho Yoon, Jin Mo Goo, Jae-Joon Yim, Takashi Yoshiyama, JoAnne L. Flynn
Summary: This article critically reviews the CT and PET findings of incipient tuberculosis without X-ray abnormalities, revealing pauci-nodular infiltrations and metabolic uptake in asymptomatic close contacts. These findings challenge the validity of simply dichotomizing cases of tuberculosis based on X-ray abnormalities and suggest the need for advanced imaging tools to stratify contacts on a continuous spectrum. Identifying incipient tuberculosis would provide an opportunity for earlier treatment.
INSIGHTS INTO IMAGING
(2022)
Article
Gastroenterology & Hepatology
William McGahan, Venkata Chikatamarla, Paul Thomas, David Cavallucci, Nicholas O'Rourke, Matthew Burge
Summary: SUVmax-p on routine FDG-PET/CT can serve as a useful indicator for predicting early post-operative recurrence and guiding additional pre-operative staging or neoadjuvant therapy.
Article
Medicine, General & Internal
Carole Durot, Eric Durot, Sebastien Mule, David Morland, Francois Godard, Anne Quinquenel, Alain Delmer, Philippe Soyer, Christine Hoeffel
Summary: The purpose of this study was to determine whether texture features on pretreatment unenhanced CT images derived from 18F-FDG PET/CT can predict survival outcomes in patients with high-tumor-burden follicular lymphoma treated with immunochemotherapy and rituximab maintenance. The study found that skewness at a fine texture scale and kurtosis without filtration were independent predictors of progression-free survival and time to next treatment. The results suggest that pretreatment unenhanced CT texture analysis-derived skewness and kurtosis can be used as predictive biomarkers for survival outcomes in patients with high-tumor-burden follicular lymphoma.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivan Ho Shon, Thomas Hennessy, Jennifer Guille, Michael P. Gotsbacher, Angelina J. Lay, Bruce McBride, Rachel Codd, Philip J. Hogg
Summary: This study evaluates the biodistribution, radiation dosimetry, safety, and tumor uptake of the novel radiopharmaceutical GA-68 ([GA-68] GA-CDI) for imaging multiple forms of cell death. The results demonstrate that GA-68 ([GA-68] GA-CDI) is safe, has low radiation dosimetry, and excellent biodistribution and imaging characteristics. It shows potential advantages over previous radiopharmaceuticals for imaging cell death and has progressed to a proof-of-concept trial.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Medicine, General & Internal
Ken Kudura, Florentia Dimitriou, Daniela Mihic-Probst, Urs J. Muehlematter, Tim Kutzker, Lucas Basler, Robert Forster, Reinhard Dummer, Joanna Mangana, Lars Husmann, Irene A. Burger, Michael Christoph Kreissl
Summary: The use of FDG-PET/CT in metastatic melanoma patients has increased significantly due to improved survival rates. Indeterminate findings on FDG-PET/CT in these patients should be further investigated, as almost half of them are malignant with the majority being melanoma metastases. Other primary malignancies are also found in a significant proportion of cases, impacting clinical management in the majority of malignant findings.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Hye Min, Seong Hyun Kim, Jeong Ah Hwang, Seung Hyup Hyun, Sang Yun Ha, Seo-Youn Choi, Seon Woo Kim, Hye Seung Kim
Summary: Both LI-RADS category on MRI and TLR on PET-CT are associated with the postoperative prognosis of PLCs. The prognosis of PLCs classified as LR-M can be further stratified according to the TLR group, but not for the PLCs classified as LR-4/5.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lijuan Feng, Xu Yang, Xia Lu, Ying Kan, Chao Wang, Dehui Sun, Hui Zhang, Wei Wang, Jigang Yang
Summary: This study developed and validated a radiomics nomogram based on F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for non-invasive prediction of bone marrow involvement (BMI) in pediatric neuroblastoma. The radiomics nomogram incorporated radiomics signature and independent clinical risk factors, and showed good predictive performance in predicting BMI.
INSIGHTS INTO IMAGING
(2022)
