Review
Biochemistry & Molecular Biology
Aine M. de Bhailis, Constantina Chrysochou, Philip A. Kalra
Summary: Ischaemic renal disease caused by atherosclerotic renovascular disease triggers a complex biological response that leads to fibrosis and chronic kidney disease. Despite large randomized control trials showing that renal revascularization does not provide additional benefits compared to medical therapy alone for patients with atherosclerotic renal artery disease, new evidence suggests targeted therapeutic interventions may be effective in countering this complex pathogenesis.
Article
Transplantation
Pantelis A. Sarafidis, Marieta Theodorakopoulou, Alberto Ortiz, Beatriz Fernandez-Fernandez, Ionut Nistor, Roland Schmieder, Mustafa Arici, Athanasios Saratzis, Patricia van der Niepen, Jean-Michel Halimi, Reinhold Kreutz, Andrzej Januszewicz, Alexandre Persu, Mario Cozzolino
Summary: Atherosclerotic renovascular disease (ARVD) is a common type of renal artery stenosis with a high risk for future cardiovascular and renal events. The evidence regarding the management of ARVD is conflicting, but some observational studies suggest potential cardiorenal benefits of percutaneous transluminal renal artery angioplasty (PTRA) in high-risk ARVD phenotypes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cell Biology
Rahele A. Farahani, Mohsen Afarideh, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Christopher M. Ferguson, Amir Lerman, Stephen C. Textor, Lilach O. Lerman, Alfonso Eirin
Summary: Percutaneous transluminal renal angioplasty (PTRA) may alleviate mitochondrial damage caused by renal artery stenosis and metabolic syndrome, improving renal function and reducing injury in the poststenotic kidney.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Christopher M. Ferguson, Rahele A. Farahani, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Amir Lerman, Lilach O. Lerman, Alfonso Eirin
Summary: This study showed that mesenchymal stem cell-derived extracellular vesicles (EVs) offer superior protection of the stenotic kidney microvasculature and greater attenuation of renal injury and fibrosis compared to percutaneous transluminal renal angioplasty (PTRA), despite both strategies similarly improving renal hemodynamics and function. The EVs were found to be enriched with pro-angiogenic, anti-inflammatory, and antioxidants genes, highlighting their potential as a promising therapeutic intervention in renovascular disease.
Review
Peripheral Vascular Disease
Ben Edgar, Robert Pearson, Ram Kasthuri, Keith Gillis, Colin Geddes, Maggie Rostron, Adrian Brady, Keith Hussey, Giles Roditi, Christian Delles, David Kingsmore
Summary: This study aimed to compare the outcomes of patients undergoing renal artery stenting based on different therapeutic aims and found that renal artery stenting is effective in treating hypertension, renal dysfunction, and pulmonary edema.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Pediatrics
Eda Didem Kurt-Sukur, Eileen Brennan, Meryl Davis, Colin Forman, George Hamilton, Nicos Kessaris, Stephen D. Marks, Clare A. McLaren, Kishore Minhas, Premal A. Patel, Derek J. Roebuck, Jelena Stojanovic, Sam Stuart, Kjell Tullus
Summary: This study retrospectively reviewed the treatment and outcome of renovascular hypertension in young children. Percutaneous transluminal angioplasty significantly improved blood pressure in children below the age of 2, with low complication rates. Surgery can be considered when percutaneous transluminal angioplasty and medical treatments fail.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Sydney Vari, Sarah-Jane Guild, Bindu George, Rohit Ramchandra
Summary: The study found that increases in ICP lead to increases in arterial pressure in normotensive animals, but this effect is severely attenuated in renovascular hypertension. Ganglionic blockade abolished the increase in arterial pressure in both groups when ICP was increased.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Naik Vietti Violi, Rami Hajri, Laura Haefliger, Marie Nicod-Lalonde, Nicolas Villard, Clarisse Dromain
Summary: Imaging of oligometastatic disease is challenging, requiring a combination of imaging modalities. The choice of imaging tool depends on tumor type, timing, metastatic location, and risk for metastasis. Commonly used modalities include CT, MRI, and metabolic imaging. Oligometastatic disease has different treatment options compared to polymetastatic disease, making imaging important for diagnosis and follow-up.
Article
Urology & Nephrology
Jeong Yeon Kim, Heeyeon Cho
Summary: This study investigated the prevalence of hypertension and clinical manifestations in Korean pediatric MMD patients, as well as the association of the RNF213 p.R4810K variant with RVH. It was found that RVH is more common than non-RVH in pediatric MMD patients, and the RNF213 p.R4810K variant may play a role in the development of hypertension in children with MMD.
CLINICAL NEPHROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Meredith A. Jones, William M. MacCuaig, Alex N. Frickenstein, Seda Camalan, Metin N. Gurcan, Jennifer Holter-Chakrabarty, Katherine T. Morris, Molly W. McNally, Kristina K. Booth, Steven Carter, William E. Grizzle, Lacey R. McNally
Summary: Inflammatory diseases are highly prevalent conditions with high mortality rates in severe cases. Imaging of the immune system and inflammatory response can provide insight into disease progression and severity, leading to improved accuracy of diagnostics and patient monitoring. High specificity molecular imaging of inflammatory biomarkers allows for earlier diagnosis to prevent irreversible damage.
Editorial Material
Urology & Nephrology
Marieta P. Theodorakopoulou, Artemios G. Karagiannidis, Charles J. Ferro, Alberto Ortiz, Pantelis A. Sarafidis
Summary: Atherosclerotic renovascular disease is the most common type of renal artery stenosis. Several large trials have failed to demonstrate the superiority of percutaneous transluminal renal angioplasty (PTRA) in addition to medical therapy compared to medical therapy alone in patients with ARVD. However, observational data suggest that PTRA may have cardiorenal benefits in high-risk ARVD patients, warranting a properly designed randomized controlled trial to confirm its superiority.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Medicine, General & Internal
Nirbaanjot Walia, Nisha Rao, Michael Garrett, Karen Yates, Sarah Malone, Christian Holmes
Summary: This study aims to assess whether PPI use is associated with an increased risk of peritonitis in PD patients. Retrospective analysis showed that the proportion of patients with peritonitis was 57% in the PPI group, compared to 31% in the non-PPI group.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Medicine, General & Internal
Yuri Sasaki, Eikan Mishima, Koichi Kikuchi, Takafumi Toyohara, Takehiro Suzuki, Hideki Ota, Kazumasa Seiji, Mariko Miyazaki, Hideo Harigae, Sadayoshi Ito, Kei Takase, Takaaki Abe
Summary: Timely angioplasty can be beneficial for select patients, even with an atrophic kidney and total occlusion, especially in cases with hypertension deterioration within six months and collateral perfusion to the affected kidney.
Article
Cardiac & Cardiovascular Systems
Zhiyong Lin, Bihui Zhang, Letao Lin, Rui Wang, Guochen Niu, Ziguang Yan, Yinghua Zou, Xiaoqiang Tong, Jianxing Qiu, Min Yang
Summary: The study demonstrated that measuring renal R2* values through BOLD-MRI could effectively predict SRF improvement in patients with severe ARAS undergoing RAS, suggesting the potential clinical utility of this method in selecting patients most likely to benefit from RAS surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Peripheral Vascular Disease
Marco Pappaccogli, Tom Robberechts, Jean-Philippe Lengele, Patricia van der Niepen, Pantelis Sarafidis, Franco Rabbia, Alexandre Persu
Summary: Atherosclerotic renovascular disease is a common cause of renovascular hypertension, with a higher prevalence in older patients and those with specific comorbidities. Apart from hypertension, this disease contributes to several clinical manifestations, including life-threatening conditions. Percutaneous renal angioplasty was initially believed to be an effective treatment, but several clinical trials failed to prove its favorable effects, possibly due to study limitations and exclusion of suitable patients. This review aims to summarize the weaknesses of previous studies and provide guidance for identifying patients who may benefit from revascularization.
