Review
Respiratory System
Siqi Li, Qiong Huang, Baimei He
Summary: Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease characterized by irreversible airflow obstruction and lung function decline. SIRT1, a member of the Sir2 family, plays important roles in oxidative stress, apoptosis, inflammation, autophagy, and cellular senescence, which are involved in the pathogenesis and development of COPD. SIRT1 activation may be a potential therapeutic strategy for COPD.
Review
Biochemistry & Molecular Biology
Yue Yu, Ailin Yang, Ganggang Yu, Haoyan Wang
Summary: This review explores the relationship between ER stress and UPR with COPD, as well as drug intervention strategies targeting the UPR pathway in COPD. By analyzing other cellular processes, new therapeutic approaches and preventive measures for COPD are investigated.
Review
Pharmacology & Pharmacy
Aleksandar Dobric, Simone N. De Luca, Sarah J. Spencer, Steven Bozinovski, Michael M. Saling, Christine F. McDonald, Ross Vlahos
Summary: Chronic obstructive pulmonary disease (COPD) is a major incurable global health burden and a leading cause of death worldwide. Cognitive dysfunction is highly prevalent in COPD and has significant impacts on quality of life and survival. Understanding the mechanisms underlying cognitive dysfunction in COPD could lead to novel therapeutic opportunities.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Elisabetta Zinellu, Angelo Zinellu, Alessandro G. Fois, Maria Carmina Pau, Valentina Scano, Barbara Piras, Ciriaco Carru, Pietro Pirina
Summary: Studies show an imbalance between oxidant and antioxidant molecules favoring the former in exacerbations of COPD, suggesting the potential usefulness of targeting oxidative stress in monitoring disease progression, particularly in patients more prone to exacerbations. Additional research with standardized methods in well-characterized populations is needed.
Review
Pharmacology & Pharmacy
Yanhui Liu, Haobo Kong, Heping Cai, Guanru Chen, Huiying Chen, Wenyi Ruan
Summary: This paper reviews the association between the PI3K/Akt pathway and COPD, aiming to identify new therapeutic targets for clinical intervention in this disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Geetha Shanmugam, Jithin S. Sunny, Sudhesna Rakshit, Melvin George, K. V. Leela, Koustav Sarkar
Summary: Dysregulated inflammatory response plays a crucial role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and Non-Small cell lung cancer (NSCLC). This research aims to uncover the link between alterations in inflammatory cytokine levels and disease progression in CD4+T cells of patients suffering from COPD and lung cancer. The findings highlight the need for epigenetic therapy for these debilitating lung diseases.
MOLECULAR IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Elisabetta Zinellu, Angelo Zinellu, Maria Carmina Pau, Barbara Piras, Alessandro G. Fois, Sabrina Mellino, Ciriaco Carru, Arduino A. Mangoni, Pietro Pirina
Summary: The review found that the concentration of GPx-1 is generally lower, while the concentration of GPx-3 does not differ significantly, suggesting an impaired antioxidant defense mechanism in COPD patients.
Article
Physiology
Xiaoyu Zhao, Qiang Zhang, Rui Zheng
Summary: Autophagy is a crucial process for cell survival, development, and tissue balance. It protects cells against oxidative stress and injury. Dysregulated autophagy caused by factors like smoking and aging can lead to increased production of reactive oxygen species (ROS) and oxidative damage. ROS activates autophagy, which helps cells adapt and reduce damage by eliminating damaged molecules and organelles. Understanding the regulation of oxidative stress and autophagy is important in chronic obstructive pulmonary disease (COPD) research.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xue Zhang, Wenchao Cong, Aiping Lu
Summary: This study evaluated the expression of Vanin-1 in COPD patients and found that Vanin-1 was significantly upregulated in the sera and lung tissues of COPD patients. The expression of Vanin-1 showed positive correlations with levels of pro-inflammatory cytokines and ROS. These findings suggest that Vanin-1 may serve as a potential biomarker and new target for the diagnosis or treatment of COPD.
Article
Virology
Petlada Yongpitakwattana, Atthapan Morchang, Aussara Panya, Nunghathai Sawasdee, Pa-thai Yenchitsomanus
Summary: Dengue virus is transmitted by Aedes mosquitoes and infects various types of cells in the human skin, leading to diseases like dengue fever. Inhibiting virus production and the cytokine storm is critical for effective treatment of DENV infection.
ARCHIVES OF VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Sarath Babu Nukala, Olga Tura-Ceide, Giancarlo Aldini, Valerie F. E. D. Smolders, Isabel Blanco, Victor Peinado, Manuel Castella, Joan Albert Barbera, Alessandra Altomare, Giovanna Baron, Marina Carini, Marta Cascante, Alfonsina D'Amato
Summary: This study quantitatively demonstrates the involvement of endothelial dysfunction in CTEPH using patient samples and network medicine approach. Dysregulation of multiple metabolic and oxidative stress pathways was identified in CTEPH endothelial cells.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Zhang Wang, Nicholas Locantore, Koirobi Haldar, Mohammadali Yavari Ramsheh, Augusta S. Beech, Wei Ma, James R. Brown, Ruth Tal-Singer, Michael R. Barer, Mona Bafadhel, Gavin C. Donaldson, Jadwiga A. Wedzicha, Dave Singh, Tom M. A. Wilkinson, Bruce E. Miller, Christopher E. Brightling
Summary: Analyzing the airway microbiome can help stratify neutrophilic COPD into subgroups that require different treatment approaches. Patients with neutrophilic COPD are susceptible to significant microbiome shifts during exacerbations, especially those in a stable state at baseline. Monitoring the temporal variability of the airway microbiome may provide insight into patient inflammatory status over time.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yafen Wang, Xiangnan Kuang, Yujie Yin, Ningxin Han, Liping Chang, Hongtao Wang, Yunlong Hou, Huixin Li, Zhen Li, Yi Liu, Yuanjie Hao, Yaru Wei, Xiaoqi Wang, Zhenhua Jia
Summary: This study found that pulmonary microvascular barrier dysfunction may play an important role in the progression of AS in COPD, and TXL can delay the progression of AS by protecting the pulmonary microvascular barrier and inhibiting ferroptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Ya-Lin Jiang, Jun Fei, Peng Cao, Chen Zhang, Min-Min Tang, Jia-Yi Cheng, Hui Zhao, Lin Fu
Summary: The study found an inverse correlation between serum cadmium concentration and pulmonary function in COPD patients, even when stratified by gender. Higher serum cadmium levels were also associated with higher COPD Assessment Test (CAT) scores. Additionally, although a non-linear relationship, serum cadmium was positively associated with inflammatory cytokines (TNF-alpha and MCP-1), which partially mediated the relationship between cadmium exposure and pulmonary function decline in COPD patients.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Firoz Alam, Sami I. Hijri, Saeed Alshahrani, Saad S. Alqahtani, Abdulmajeed M. Jali, Rayan A. Ahmed, Mansour M. Adawi, Sameeh M. Algassmi, Emad Sayed Shaheen, Sivakumar S. Moni, Tarique Anwer
Summary: This study found that zingerone can alleviate carfilzomib-induced cardiotoxicity. By enhancing antioxidant properties, reducing inflammatory cytokines, and decreasing apoptotic markers, zingerone significantly improves the heart damage caused by carfilzomib in rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)