Article
Immunology
David Aguilera-Alonso, Silke Kirchschlager Nieto, Maria Fatima Ara Montojo, Francisco Jose Sanz Santaeufemia, Jesus Saavedra-Lozano, Beatriz Soto, Maria Belen Caminoa, Arantxa Berzosa, Luis Prieto Tato, Emilia Cercenado, Alfredo Tagarro, David Molina Arana, Mercedes Alonso Sanz, Maria Pilar Romero Gomez, Fernando Chaves Sanchez, Fernando Baquero-Artigao
Summary: The incidence of Staphylococcus aureus community-acquired pneumonia (CAP) remained stable in hospitalized children with high pneumococcal vaccination coverage, while the prevalence of pneumococcal CAP decreased and Streptococcus pyogenes CAP increased. Patients with S. aureus CAP had a high frequency of severe outcomes but a lower risk of pulmonary complications compared to patients with S. pneumoniae.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Infectious Diseases
Massa Dit Achille Bonko, Palpouguini Lompo, Marc Christian Tahita, Francois Kiemde, Ibrahima Karama, Athanase M. Some, Petra F. Mens, Sandra Menting, Halidou Tinto, Henk D. F. H. Schallig
Summary: The study found bacterial colonization in 154 children, with 96.1% carrying S. aureus, 3.2% carrying S. pneumoniae, and 0.6% carrying both. S. aureus showed high resistance to penicillin (96.0%), while S. pneumoniae was highly resistant to tetracycline and trimethoprim-sulfamethoxazole, and moderately resistant to penicillin. Furthermore, 4.0% of identified S. aureus were methicillin resistant.
Article
Biochemistry & Molecular Biology
Teppei Okabe, Yosuke Kamiya, Takeshi Kikuchi, Hisashi Goto, Masayuki Umemura, Yuki Suzuki, Yoshihiko Sugita, Yoshikazu Naiki, Yoshiaki Hasegawa, Jun-ichiro Hayashi, Shotaro Kawamura, Noritaka Sawada, Yuhei Takayanagi, Takeki Fujimura, Naoya Higuchi, Akio Mitani
Summary: This study found that the culture supernatant of Porphyromonas gingivalis accelerated inflammation in the lungs of Streptococcus pneumoniae-infected mice, and increased inflammatory cell infiltration. Compared to S. pneumoniae infection alone, PgSup synergistically increased TNF-alpha and IL-17 expression/production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Tomoko Sumitomo, Masanobu Nakata, Satoshi Nagase, Yuki Takahara, Mariko Honda-Ogawa, Yasushi Mori, Yukako Akamatsu, Masaya Yamaguchi, Shigefumi Okamoto, Shigetada Kawabata
Summary: Influenza A virus infection increases susceptibility to secondary bacterial pneumonia, with GP96 on infected cell surfaces mediating interactions with Streptococcus pneumoniae, leading to increased bacterial adherence and translocation. Inhibition of GP96 enhances pneumococcal clearance and reduces lung pathology in infected mice, suggesting a potential therapeutic target for inhibiting bacterial colonization in an IAV-infected respiratory tract.
Article
Infectious Diseases
Hideo Kato, Mao Hagihara, Yoshihiko Morikawa, Nobuhiro Asai, Hiroshige Mikamo, Takuya Iwamoto
Summary: This study retrospectively evaluated the effectiveness and safety of ceftriaxone administered twice daily with a dosage of 1 g versus ceftriaxone administered once daily with a dosage of 2 g for the treatment of aspiration pneumonia. The results showed that the once daily administration of 2 g ceftriaxone had significantly improved clinical responses compared to the twice daily administration of 1 g. The incidence of choleliths during ceftriaxone therapy was also found to be lower in the once daily administration group.
Article
Microbiology
Ana G. Jop Vidal, Babek Alibayov, I. J. Frame, Landon Murin, Aidan Creel, Dongping Hu, Xueqing Wu, Jorge E. Vidal
Summary: Streptococcus pneumoniae kills Staphylococcus aureus through a contact-dependent mechanism that is facilitated by cations, including iron. Some strains of S. pneumoniae have acquired the Mega gene to resist macrolide antibiotics. Our study found that disrupting iron acquisition or using Mega to resist antibiotics did not inhibit the killing mechanism.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Pediatrics
Dongdong Wang, Jianshe Zhao, Ran Zhang, Qinghu Yan, Lu Zhou, Xiaoyu Han, Yafei Qi, Dexin Yu
Summary: This study investigated the value of CT radiomics in differentiating mycoplasma pneumoniae pneumonia (MPP) from streptococcus pneumoniae pneumonia (SPP) in children under 5 years old. The random forest (RF) model was found to have the best classification efficiency in identifying MPP from SPP.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pharmacology & Pharmacy
Yuancheng Chen, Xiaojie Wu, Chengyuan Tsai, Liwen Chang, Jicheng Yu, Guoying Cao, Beining Guo, Yaoguo Shi, Demei Zhu, Fupin Hu, Jinyi Yuan, Yang Liu, Xu Zhao, Yingyuan Zhang, Jufang Wu, Jing Zhang
Summary: Integrative PK/PD analysis supports the reliable clinical and microbiological efficacy of nemonoxacin 500 mg q24 h in treating community-acquired pneumonia caused by S. pneumoniae, S. aureus, and K. pneumoniae, regardless of patient sex, mild renal impairment, empty stomach or not. However, nemonoxacin 750 mg q24 h would provide better efficacy than 500 mg q24 h for CAP caused by H. parainfluenzae in terms of CFR.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Eileen M. Dunne, Yinglei Hua, Rasheed Salaudeen, Ilias Hossain, Malick Ndiaye, Belinda D. Ortika, E. Kim Mulholland, Jason Hinds, Sam Manna, Grant A. Mackenzie, Catherine Satzke
Summary: We investigated the pathogenesis of pneumococcal pneumonia using clinical samples. Results demonstrated that pneumococci in the lung originated from the nasopharynx and suggested that changes in pneumococcal gene expression in the lung are a feature of pneumococcal pneumonia.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Health Care Sciences & Services
Christopher C. Blyth, Kathryn J. Britton, Cattram D. Nguyen, Joycelyn Sapura, John Kave, Birunu Nivio, Jocelyn Chan, Catherine Satzke, Rebecca Ford, Wendy Kirarock, Deborah Lehmann, William Pomat, Fiona M. Russell
Summary: This study evaluates the effectiveness of the 13-valent pneumococcal conjugate vaccine (13vPCV) in reducing hypoxic pneumonia and hospitalization in children in Eastern Highlands Province, Papua New Guinea (PNG).
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Review
Infectious Diseases
Lucia Fernandez, Maria Dolores Cima-Cabal, Ana Catarina Duarte, Ana Rodriguez, Maria del Mar Garcia-Suarez, Pilar Garcia
Summary: Pneumonia, whether viral or bacterial, presents challenges to healthcare systems and effective antimicrobial strategies. Antibiotic resistance in bacterial pneumonia is a main concern, and alternative therapeutics like phage therapy may offer a solution. Regulatory hurdles and research difficulties remain obstacles to the clinical use of phage therapy.
Article
Immunology
Flavia Rayssa Braga Martins, Maycon Douglas de Oliveira, Jessica Amanda Marques Souza, Celso Martins Queiroz-Junior, Francisco Pereira Lobo, Mauro Martins Teixeira, Nathalia Luisa Malacco, Frederico Marianetti Soriani
Summary: This study aimed to investigate the inflammatory mechanisms involved in pneumococcal pneumonia associated with chronic ethanol exposure. The results showed that alcohol-fed mice produced higher levels of nitric oxide and CXCL1 during pneumonia, exhibited reduced leukocyte infiltration and less severe lung inflammation, but no changes in survival after infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Sunil Palani, Md Bashir Uddin, Michael McKelvey, Shengjun Shao, Keer Sun
Summary: The susceptibility of B6 mice to pneumococcal pneumonia after mild IAV infection is primarily attributed to the type 1 immune predisposition. IFN-γ signaling inhibits neutrophil recruitment and bacterial clearance in B6 mice, leading to lethal coinfection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ivan Felipe Gutierrez-Tobar, Juan Pablo Londono-Ruiz, Cristina Marino-Drews, Sandra Beltran-Higuera, German Camacho-Moreno, Aura Lucia Leal-Castro, Jaime Alberto Patino-Nino, Martha Isabel Alvarez-Olmos, Rocio Barrero-Barreto, Fabio Espinosa, Maria Alejandra Suarez, Nicolas Ramos, Vivian Marcela Moreno-Mejia, Alejandra Marin, Claudia Rocio Sierra Parada, Angela Pescador, Anita Montanez
Summary: Introduction of PCV10 vaccine in Colombia significantly reduced cases of serotypes 1 and 14 pneumonia, but there was an increase in cases of serotypes 19A, 3, and 6A, which had greater severity and resistance. The study supports the use of higher-valence vaccines, such as PCV13, to reduce the circulation of these serotypes.
Article
Infectious Diseases
Catia Cilloniz, Cristina Dominedo, Albert Gabarrus, Carolina Garcia-Vidal, Jose Becerril, Diego Tovar, Estela Moreno, Juan M. Pericas, Carmen Rosa Vargas, Antoni Torres
Summary: This study aimed to describe the prevalence, risk factors, and outcomes of MSSA community-acquired pneumonia and found that MSSA CAP patients had higher 30-day mortality than pneumococcal CAP patients, with MSSA being an independent factor of mortality.
JOURNAL OF INFECTION
(2021)