Article
Engineering, Biomedical
Richard Speight, Michael Dubec, Cynthia L. Eccles, Ben George, Ann Henry, Trina Herbert, Robert Johnstone, Gary P. Liney, Hazel McCallum, Maria A. Schmidt
Summary: This document provides guidance for establishing and using an MRI-guided radiotherapy treatment planning service, based on the experience of institutions represented in the IPEM working group. It focuses on the use of MRI for external beam RT treatment planning within a CT-based workflow, and provides practical advice on training, patient set-up, MRI sequence optimization, and commissioning and QA for MR scanners. Not covered in this document are other uses of MRI for RT, such as treatment response assessment and MRI-only RT.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Engineering, Biomedical
Paul Z. Y. Liu, Mark Gardner, Soo Min Heng, Chun-Chen Shieh, Doan Trang Nguyen, Emily Debrot, Ricky O'Brien, Simon Downes, Michael Jackson, Paul J. Keall
Summary: The study demonstrates an image-guided treatment workflow using a fixed beam prototype system to maintain dosimetric accuracy during rotation. By utilizing motion compensated CBCT and KIM techniques, the position of the target was quantified and tracked in real-time as the patient rotated.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Review
Oncology
I-Chow Hsu, Emi Yoshida
Summary: Ultrasound is an important tool in cervical cancer treatment, providing real-time imagery and improving the physician's spatial awareness. Its routine use has been supported by mounting evidence and it has been widely used in clinical practice.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Computer Science, Information Systems
Maximilian Kraemer, Torsten Bertram
Summary: Trajectory optimization is a promising method for planning robotic manipulator trajectories, especially in dynamic environments with collaborative robots. This paper introduces two approaches to improve the quality of trajectory optimization: Extended Initialization reduces the risk of local minima, while globally guiding local solutions mitigates critical cases of standstills.
Article
Computer Science, Artificial Intelligence
R. Han, A. Uneri, R. C. Vijayan, P. Wu, P. Vagdargi, N. Sheth, S. Vogt, G. Kleinszig, G. M. Osgood, J. H. Siewerdsen
Summary: The study introduces a multi-body registration framework for pelvic fracture reduction planning and intraoperative guidance using preoperative CT and routine 2D fluoroscopy. The framework showed promising results in simulation and clinical feasibility studies, with improved accuracy and reduced radiation exposure, demonstrating its potential in enhancing pelvic fracture reduction outcomes in a variety of cases.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Oncology
Joel A. Pogue, Carlos E. Cardenas, Yanan Cao, Richard A. Popple, Michael Soike, Drexell Hunter Boggs, Dennis N. Stanley, Joseph Harms
Summary: This study investigates the feasibility of automatically generating high-quality APBI plans in the Ethos adaptive workspace with a focus on sparing the heart. The results show that the Ethos template generated plans with better evaluation planning target volume coverage and reduced heart radiation dose compared to manually generated plans. This approach provides a way for generating efficient cardiac-sparing APBI treatment plans for daily adaptive RT.
FRONTIERS IN ONCOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Chen Zhang, Yihong Li, Xinyong Ma, Wenxin He, Chenxi Liu, Zhe Liu
Summary: Chemically functionalized gas-filled bubbles at micro/nano scale have shown great potential in disease diagnosis and treatment, with applications in biomedical imaging, drug delivery, gene transfection, and disease-oriented therapy. The use of ultrasound in conjunction with functional micro/nanobubbles has led to significant advancements in disease precision therapy and holds promise for future healthcare advancements.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Dagmar Bertsche, Wolfgang Rottbauer, Volker Rasche, Dominik Buckert, Sinisa Markovic, Patrick Metze, Birgid Gonska, Erfei Luo, Tillman Dahme, Ina Vernikouskaya, Leonhard M. Schneider
Summary: This study proposes a vendor-independent approach to integrate planning details into periprocedural image fusion, aiming to enhance the interventional treatment of structural heart disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Luise A. Kuenzel, Marcel Nachbar, Markus Hagmueller, Cihan Gani, Simon Boeke, Daniel Zips, Daniela Thorwarth
Summary: The study implemented an autonomous un-supervised treatment planning approach using deep learning and logical volume operators, successfully applied to a prostate cancer patient. The automatically generated plan met most dosimetric criteria and performed well during online adaptation.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Brady S. Laughlin, Nathan Y. Y. Yu, Stephanie Lo, Jingwei Duan, Zachary Welchel, Katie Tinnon, Mason Beckett, Steven E. Schild, William W. W. Wong, Sameer R. Keole, Jean-Claude M. Rwigema, Carlos E. Vargas, Yi Rong
Summary: This study aimed to evaluate the feasibility of reducing the PTV margin using high-quality iCBCT image guidance. The analysis revealed that both 2 mm and 4 mm margins are feasible for patients requiring radiotherapy. For patients requiring an endorectal balloon, a 2 mm or 4 mm margin expansion is also feasible.
Article
Engineering, Biomedical
Lydia J. Wilson, Wayne D. Newhauser
Summary: This study developed an outcome-based objective function to directly optimize projected health outcomes, showing that outcome-optimized radiotherapy (OORT) was superior to dose-optimized radiotherapy (DORT) in improving projected health outcomes for prostate cancer patients. The results were consistent across treatment modalities, late-risk models, and individual patients, suggesting the feasibility of optimizing longitudinal health outcomes associated with total absorbed dose in all tissues for cancer patients. This approach offers a simpler, more direct way to realize the full beneficial potential of cancer radiotherapy.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Engineering, Civil
Bruno Brito, Achin Agarwal, Javier Alonso-Mora
Summary: This paper presents a novel framework for interaction-aware motion planning in dense traffic scenarios. By combining deep reinforcement learning and optimization-based planning, the proposed method significantly reduces collisions and increases the success rate in interactive simulation environments.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2022)
Article
Engineering, Biomedical
Aaron Babier, Rafid Mahmood, Binghao Zhang, Victor G. L. Alves, Ana Maria Barragan-Montero, Joel Beaudry, Carlos E. Cardenas, Yankui Chang, Zijie Chen, Jaehee Chun, Kelly Diaz, Harold David Eraso, Erik Faustmann, Sibaji Gaj, Skylar Gay, Mary Gronberg, Bingqi Guo, Junjun He, Gerd Heilemann, Sanchit Hira, Yuliang Huang, Fuxin Ji, Dashan Jiang, Jean Carlo Jimenez Giraldo, Hoyeon Lee, Jun Lian, Shuolin Liu, Keng-Chi Liu, Jose Marrugo, Kentaro Miki, Kunio Nakamura, Tucker Netherton, Dan Nguyen, Hamidreza Nourzadeh, Alexander F. Osman, Zhao Peng, Jose Dario Quinto Munoz, Christian Ramsl, Dong Joo Rhee, Juan David Rodriguez, Hongming Shan, Jeffrey Siebers, Mumtaz H. Soomro, Kay Sun, Andres Usuga Hoyos, Carlos Valderrama, Rob Verbeek, Enpei Wang, Siri Willems, Qi Wu, Xuanang Xu, Sen Yang, Lulin Yuan, Simeng Zhu, Lukas Zimmermann, Kevin L. Moore, Thomas G. Purdie, Andrea L. McNiven, Timothy C. Y. Chan
Summary: This study establishes an open framework for developing plan optimization models for knowledge-based planning (KBP). By analyzing the treatment data of 100 head-and-neck cancer patients, it is found that the quality of predictions is generally positively correlated with the quality of plans. The KBP pipelines generated better plans compared to the predictions and the framework is also applicable to inverse planning models. Moreover, this study provides valuable data and code for further research in this field.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Physics, Multidisciplinary
Monique Y. Y. Heinke, Lois Holloway, Robba Rai, Shalini K. K. Vinod
Summary: The study aimed to assess the repeatability of MRI for radiotherapy treatment planning by comparing the registration of MRI to MRI and CT to MRI. The results showed that MRI to MRI registration demonstrated more consistency in delineated volumes compared to CT to MRI registration.
FRONTIERS IN PHYSICS
(2022)
Article
Oncology
Siti Masitho, Johanna Grigo, Tobias Brandt, Ulrike Lambrecht, Juliane Szkitsak, Alexander Weiss, Rainer Fietkau, Florian Putz, Christoph Bert
Summary: This study assessed the role of auxiliary devices in sCT-based TP for MRI-only brain radiotherapy. The dosimetric impact of the auxilary devices on the sCT-based TP was investigated by placing an auxiliary structure template (AST) on the MRI. The results showed that the impact of auxiliary devices was within an acceptable range.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Oncology
Stuart E. Samuels, Avraham Eisbruch, Karen Vineberg, Jae Lee, Choonik Lee, Martha M. Matuszak, Randall K. Ten Haken, Kristy K. Brock
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2016)
Article
Oncology
Daniel F. Polan, Mary Feng, Theodore S. Lawrence, Randall K. Ten Haken, Kristy K. Brock
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2017)
Article
Oncology
Arthur Jochems, Timo M. Deist, Issam El Naqa, Marc Kessler, Chuck Mayo, Jackson Reeves, Shruti Jolly, Martha Matuszak, Randall Ten Haken, Johan van Soest, Cary Oberije, Corinne Faivre-Finn, Gareth Price, Dirk de Ruysscher, Philippe Lambin, Andre Dekker
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2017)
Article
Oncology
Shulian Wang, Jeff Campbell, Matthew H. Stenmark, Jing Zhao, Paul Stanton, Martha M. Matuszak, Randall K. Ten Haken, Feng-Ming (Spring) Kong
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2017)
Article
Oncology
Robert T. Dess, Yilun Sun, Martha M. Matuszak, Grace Sun, Payal D. Soni, Latifa Bazzi, Venkatesh L. Murthy, Jason W. D. Hearn, Feng-Ming Kong, Gregory P. Kalemkerian, James A. Hayman, Randall K. Ten Haken, Theodore S. Lawrence, Matthew J. Schipper, Shruti Jolly
JOURNAL OF CLINICAL ONCOLOGY
(2017)
Article
Oncology
Payal D. Soni, Philip S. Boonstra, Matthew J. Schipper, Latifa Bazzi, Robert T. Dess, Martha M. Matuszak, Feng-Ming Kong, James A. Hayman, Randall K. Ten Haken, Theodore S. Lawrence, Gregory P. Kalemkerian, Shruti Jolly
JOURNAL OF THORACIC ONCOLOGY
(2017)
Article
Oncology
Peter G. Hawkins, Philip S. Boonstra, Stephen T. Hobson, Jason W. D. Hearn, James A. Hayman, Randall K. Ten Haken, Martha M. Matuszak, Paul Stanton, Gregory P. Kalemkerian, Nithya Ramnath, Theodore S. Lawrence, Matthew J. Schipper, Feng-Ming (Spring) Kong, Shruti Jolly
RADIOTHERAPY AND ONCOLOGY
(2017)
Article
Oncology
Yi Luo, Issam El Naqa, Daniel L. McShan, Dipankar Ray, Ines Lohse, Martha M. Matuszak, Dawn Owen, Shruti Jolly, Theodore S. Lawrence, Feng-Ming (Spring) Kong, Randall K. Ten Haken
RADIOTHERAPY AND ONCOLOGY
(2017)
Article
Oncology
Charles S. Mayo, Martha M. Matuszak, Matthew J. Schipper, Shruti Jolly, James A. Hayman, Randall K. Ten Haken
FRONTIERS IN ONCOLOGY
(2017)
Article
Oncology
Matthew M. Cousins, Emily Morris, Christopher Maurino, Theresa P. Devasia, David Karnak, Dipankar Ray, Neehar D. Parikh, Dawn Owen, Randall K. Ten Haken, Matthew J. Schipper, Theodore S. Lawrence, Kyle C. Cuneo
Summary: This study investigated the impact of liver radiation therapy on liver function. The findings suggest that elevated plasma sTNFR1 levels are associated with liver injury after liver radiation, indicating that increased inflammatory cytokine activity is a predictor of radiation-induced liver dysfunction.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Daniel J. Herr, Chang Wang, Mishal Mendiratta-Lala, Martha Matuszak, Charles S. Mayo, Yue Cao, Neehar D. Parikh, Randy Ten Haken, Dawn Owen, Joseph R. Evans, Teodor Stanescu, Michael Yan, Laura A. Dawson, Matthew Schipper, Theodore S. Lawrence, Kyle C. Cuneo
Summary: Optimizing stereotactic body radiotherapy (SBRT) based on individual patient's probability for tumor control and risk of liver injury can decrease treatment-related toxicity while maintaining tumor control in patients with impaired liver function or tumors not amenable to thermal ablation.
CLINICAL CANCER RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sunan Cui, Yi Luo, Huan-Hsin Tseng, Randall K. Ten Haken, Issam El Naqa
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yi Luo, Daniel McShan, Dipankar Ray, Martha Matuszak, Shruti Jolly, Theodore Lawrence, Feng-Ming Kong, Randall Ten Haken, Issam El Naqa
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2019)
Article
Oncology
Joseph J. Foy, Robin Marsh, Randall K. Ten Haken, Kelly C. Younge, Matthew Schipper, Yilun Sun, Dawn Owen, Martha M. Matuszak
PRACTICAL RADIATION ONCOLOGY
(2017)
Review
Engineering, Biomedical
Issam El Naqa, Sarah L. Kerns, James Coates, Yi Luo, Corey Speers, Catharine M. L. West, Barry S. Rosenstein, Randall K. Ten Haken
PHYSICS IN MEDICINE AND BIOLOGY
(2017)
