Review
Biology
Xinyun Su, Akshaya Upadhyay, Simon D. D. Tran, Zhengmei Lin
Summary: Radiation therapy for cancer treatment can lead to damage to healthy tissues and organs, like salivary glands. Loss of salivary function can result in various complications and decreased quality of life for patients. Current treatment methods are insufficient, and this review explores the potential of stem cell-derived extracts as a promising treatment strategy, comparing it to other cell-free therapies.
Review
Cell Biology
Xiaoyu Pu, Siyang Ma, Yan Gao, Tiankai Xu, Pengyu Chang, Lihua Dong
Summary: Radiation-induced damage is common in cancer patients undergoing radiotherapy, with mesenchymal stem cells and exosomes derived from them being ideal candidates for repair. Exosomes carry various bioactive substances that can affect immunomodulation, angiogenesis, cell survival, and proliferation, potentially providing new insights into the management of radiation damage.
Article
Biology
Daojiang Yu, Shuaijun Zhang, Wei Mo, Zhiqiang Jiang, Min Wang, Lu An, Youyou Wang, Yulong Liu, Sheng Jiang, Ailing Wu, Jianping Cao, Shuyu Zhang
Summary: Severe radiation-induced skin injury is a potential complication of tumor radiotherapy and nuclear accidents. Cell therapy using stromal vascular fraction (SVF) derived from adipose tissue has shown promising results in promoting wound healing. Proteomic profiling revealed upregulated and downregulated proteins in SVF-co-cultured human skin fibroblast WS1 cells, indicating the potential of SVF in modulating the microenvironment for skin regeneration. Transplantation of SVF was found to significantly improve wound healing and relieve pain in patients with radiation-induced skin injury, suggesting SVF as an effective treatment option.
RADIATION RESEARCH
(2021)
Review
Cell Biology
Carole Helissey, Sophie Cavallero, Clement Brossard, Marie Dusaud, Cyrus Chargari, Sabine Francois
Summary: Radiation cystitis is a potential complication of pelvic cancer treatment, with unclear clinical management and underlying pathophysiology. The lack of prospective and randomized trials makes establishing therapeutic strategies difficult. The immunopathological processes and fibrotic process of radiation cystitis, as well as potential therapeutic approaches focusing on the interaction between mesenchymal stromal cells and macrophages, are key points of discussion.
Review
Biochemistry & Molecular Biology
Francesca Miglietta, Gaia Palmini, Francesca Giusti, Simone Donati, Cinzia Aurilia, Teresa Iantomasi, Maria Luisa Brandi
Summary: Hypoparathyroidism is a disorder characterized by low calcium levels, high phosphorus levels, and insufficient or absent secretion of PTH. Hormone replacement therapy with calcium and vitamin D is common, but may not always be effective long-term. Glandular autotransplantation is considered the most effective treatment, while allograft has limited success due to tissue rejection and side effects from systemic immunosuppression. Research is ongoing to discover alternative graft therapies with optimal results and minimal side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell & Tissue Engineering
Dehua Chang, Taibing Fan, Shuang Gao, Yongqiang Jin, Mingkui Zhang, Minoru Ono
Summary: The review discusses the use of MSC sheets for improving cardiac function and alleviating adverse ventricular remodeling in ischemic heart tissue. Among various types of MSCs, UC-MSCs are highlighted as a promising candidate due to their unique features and ease of isolation and culture.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Medicine, Research & Experimental
Ling Zhang, Qian Liu, Haoran Hu, Lu Zhao, Keyang Zhu
Summary: This review discusses the therapeutic value of mesenchymal stem cells (MSCs) in various diseases and explores the mechanisms and regulatory factors involved in mitochondria transfer and restoration of mitochondrial function in injured somatic cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cell & Tissue Engineering
Margit Rosner, Markus Hengstschlager
Summary: Clinicians and patients hope that stem cell-based therapies will be effective remedies for various diseases and injuries. However, the use of pluripotent stem cells is still hindered by their potential to cause immune reactions and tumor formation. In addition, stem cells can influence the behavior of nearby cells, which can have both beneficial and detrimental effects on therapeutic outcomes.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Veronica Varzi, Emiliano Fratini, Mauro Falconieri, Daniela Giovannini, Alessia Cemmi, Jessica Scifo, Ilaria Di Sarcina, Pietro Apra, Sofia Sturari, Lorenzo Mino, Giulia Tomagra, Erminia Infusino, Valeria Landoni, Carmela Marino, Mariateresa Mancuso, Federico Picollo, Simonetta Pazzaglia
Summary: Nanodiamonds are being studied for their potential to enhance radiation effects, and this study explores the influence of their chemical and physical properties on cellular radiosensitivity. The results show that hydrogenated nanodiamonds can decrease cellular viability and increase radiosensitivity, while oxidized nanodiamonds do not. Higher energy radiation is more effective in combination with hydrogenated nanodiamonds. The molecular mechanism of nanodiamond radiosensitization involves Caspase-3-dependent apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Alina Constantin, Ioana Karla Comarita, Nicoleta Alexandru, Alexandru Filippi, Florina Bojin, Mihaela Gherghiceanu, Alexandra Vilcu, Miruna Nemecz, Loredan Stefan Niculescu, Virgil Paunescu, Adriana Georgescu
Summary: This study investigated the effects of stem cell-derived extracellular vesicles (EVs) on cardiac hypertrophy. The results showed that these EVs could reduce the expression of hypertrophic markers and molecules associated with inflammation in hypertrophic cardiomyocytes. The findings suggest that EVs have the potential to act as therapeutic mediators to reduce cardiac hypertrophy and subsequent cardiovascular events.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Ben Jiahe Gu, David K. Kung, Han-Chiao Isaac Chen
Summary: Cell therapy is seen as a promising strategy in enhancing recovery for stroke survivors, yet successful clinical translation remains elusive. This study highlights a mechanistic shift in cell therapy trials from replacing dead neurons in early studies to focusing on neuromodulation effects in later studies, emphasizing that both mechanisms are worth pursuing. It also stresses the importance of finding ways to achieve cell replacement in stroke treatment.
Article
Oncology
Adam Szmul, Edward Chandy, Catarina Veiga, Joseph Jacob, Alkisti Stavropoulou, David Landau, Crispin T. Hiley, Jamie R. McClelland
Summary: Radiation-induced lung damage (RILD) is a common side effect of radiotherapy (RT) for lung cancer. This study proposes a five-class morphological lung tissue classification system to describe and differentiate different types of RILD. The classification system was automated and achieved considerable overlap with manual segmentations. The proposed framework for auto-segmentation of different lung tissue classes produces acceptable results and has the potential to facilitate future large studies of RILD.
Article
Pharmacology & Pharmacy
Tiancong Wu, Jianhua Gao, Wen Liu, Jian Cui, Miaofang Yang, Wenjie Guo, Fang-Yu Wang
Summary: This study found that NLRP3 deficiency increased the mortality rate and aggravated colon damage in mice exposed to radiation. The results suggest that NLRP3 may protect mice from radiation-induced tissue damage by attenuating the cGAS-STING signaling pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Cell Biology
Qiu Chen, Lei Yao, Quanbin Liu, Jun Hou, Xinyu Qiu, Mengyuan Chen, Zhuojun Wu, Duanmin Hu, Fengmei Cui, Tao Yan
Summary: This study aimed to develop exosome-coated polydatin nanoparticles (exo-PD) to improve the solubility and bioavailability of polydatin and explore its effects on intestinal radiation injury. Results showed that exo-PD improved cell viability, prolonged survival, improved leukocyte count, and reduced diarrhea rate. Histological results showed significant improvements in small intestinal villus length and crypt number in the exo-PD group.
Review
Oncology
Alexander Ruhle, Anca-Ligia Grosu, Nils H. Nicolay
Summary: MSCs have regenerative abilities that may have therapeutic effects on tissue damage caused by particle radiation in cancer radiotherapy. With the increasing number of proton therapy centers, further research is needed to investigate the effects of MSC-based treatments on particle radiation-induced sequelae. Therapies involving MSCs or MSC-derived exosomes may also have applications in manned space exploration or post-radiation accidents and nuclear terrorism.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pascal K. C. Jonker, Madelon J. H. Metman, Luc H. J. Sondorp, Mark S. Sywak, Anthony J. Gill, Liesbeth Jansen, Thera P. Links, Paul J. van Diest, Tessa M. van Ginhoven, Clemens W. G. M. Lowik, Anh H. Nguyen, Robert P. Coppes, Dominic J. Robinson, Gooitzen M. van Dam, Bettien M. van Hemel, Rudolf S. N. Fehrmann, Schelto Kruijff
Summary: This study suggests that molecular fluorescence-guided imaging and spectroscopy can be useful in detecting nodal metastases in patients with papillary thyroid cancer undergoing prophylactic central compartment dissection. The overexpression of MET in PTC is associated with increased locoregional recurrence rates. The use of a near-infrared fluorescent tracer targeting MET, EMI-137, can facilitate the detection of metastases and potentially reduce unnecessary surgeries.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Letter
Oncology
Roel J. H. M. Steenbakkers, Maria I. van Rijn-Dekker, Monique A. Stokman, Roel G. J. Kierkels, Arjen van der Schaaf, Johanna G. M. van den Hoek, Hendrik P. Bijl, Maria C. A. Kramer, Rob P. Coppes, Johannes A. Langendijk, Peter van Luijk
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Cell & Tissue Engineering
Vivian M. L. Ogundipe, John T. M. Plukker, Thera P. Links, Rob P. Coppes
Summary: The incidence of treatment of thyroid disease and consequential hypothyroidism has been increasing. Regenerative medicine through tissue engineering could provide potential therapy by establishing tissue engineering models.
TISSUE ENGINEERING PART A
(2022)
Article
Pharmacology & Pharmacy
Hongmei Dong, Liang Du, Songwang Cai, Wan Lin, Chaoying Chen, Matthew Still, Zhimeng Yao, Robert P. Coppes, Yunlong Pan, Dianzheng Zhang, Shegan Gao, Hao Zhang
Summary: This study reveals the correlation between PTPRO and lapatinib resistance in ERBB2-positive breast cancer, suggesting that PTPRO can serve as an independent prognostic indicator and upregulating PTPRO can reverse the resistance to lapatinib.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Liang Du, Da Wang, Peter W. Nagle, Andries A. H. Groen, Hao Zhang, Christina T. Muijs, John Th M. Plukker, Robert P. Coppes
Summary: Esophageal cancer is a highly aggressive disease with poor prognosis. The hypoxia-responding mTOR pathway plays a crucial role in the regulation of esophageal cancer stem-like cells (CSCs). Targeting the mTOR pathway could be a potential therapeutic strategy for eliminating putative esophageal CSCs.
Letter
Oncology
Roel J. H. M. Steenbakkers, Maria I. van Rijn-Dekker, Monique A. Stokman, Arjen van der Schaaf, Johanna G. M. van den Hoek, Hendrik P. Bijl, Maria C. A. Kramer, Johannes A. Langendijk, Peter van Luijk, Roel G. J. Kierkels, Rob P. Coppes
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Review
Oncology
Julia Wiedemann, Robert P. Coppes, Peter van Luijk
Summary: Radiotherapy is commonly used in the treatment of thoracic cancers, but it can also have adverse effects on the heart and lung tissue. Heart doses can lead to cardiac effects, while lung irradiation often results in pneumonitis and pulmonary fibrosis. Lung irradiation has been found to cause remodeling of the pulmonary vasculature, leading to pulmonary hypertension-like symptoms. This knowledge of similarities could potentially help develop interventions for patients receiving thoracic radiation.
FRONTIERS IN ONCOLOGY
(2022)
Correction
Oncology
Roel J. H. M. Steenbakkers, Maria I. Van Rijn-Dekker, Monique A. Stokman, Roel G. J. Kierkels, Arjen Van der Schaaf, Johanna G. M. Van den Hoek, Hendrik P. Bijl, Maria C. A. Kramer, Rob P. Coppes, Johannes A. Langendijk, Peter Van Luijk
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Editorial Material
Oncology
Marie-Catherine Vozenin, Andreas Schuller, Marie Dutreix, Karen Kirkby, Michael Baumann, Rob P. Coppes, David Thwaites
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Cell & Tissue Engineering
Milou E. Noltes, Luc H. J. Sondorp, Laura Kracht, Ines F. Antunes, Rene Wardenaar, Wendy Kelder, Annelies Kemper, Wiktor Szymanski, Wouter T. Zandee, Liesbeth Jansen, Adrienne H. Brouwers, Robert P. Coppes, Schelto Kruijff
Summary: This study aims to establish a patient-derived organoid model representing human parathyroid tissue. Through cultivation and characterization, it is confirmed that this model resembles parathyroid tissue in terms of gene and protein expression as well as functionality, which can contribute to future research on physiology and discovery of therapeutic targets and tracers.
Article
Multidisciplinary Sciences
Paola Serrano Martinez, Martti Maimets, Reinier Bron, Ronald van Os, Gerald de Haan, Sarah Pringle, Robert P. Coppes
Summary: Stem/progenitor cells play a crucial role in maintaining salivary gland function and generating functional cells. However, there is limited understanding of stem/progenitor cells in the submandibular gland, particularly their contribution to adult gland homeostasis and the differences between embryonic and adult stem/progenitor cells. This study used a pulse-and-chase system to investigate potential stem/progenitor cells in the submandibular gland and found that label-retaining cells were mainly located in ductal or mesenchymal cells, rather than stem/progenitor cells. These label-retaining cells showed limited self-renewal ability, while non-label retaining cells exhibited differentiation and long-term expansion potential as organoids.
Review
Engineering, Biomedical
Frank Verhaegen, Karl T. Butterworth, Anthony J. Chalmers, Rob P. Coppes, Dirk de Ruysscher, Sophie Dobiasch, John D. Fenwick, Patrick Granton, Stefan H. J. Heijmans, Mark A. Hill, Constantinos Koumenis, Kirsten Lauber, Brian Marples, Katia Parodi, Lucas C. G. G. Persoon, Nick Staut, Anna Subiel, Rianne D. W. Vaes, Stefan van Hoof, Ioannis L. Verginadis, Jan J. Wilkens, Kaye J. Williams, George D. Wilson, Ludwig J. Dubois
Summary: This paper provides an overview of precision preclinical x-ray radiation studies in animal models. It focuses on cancer and normal tissue response to radiation, but also addresses other disease models. The advancements in imaging, irradiation, dosimetry, and monitoring are discussed, along with future developments. The paper also explores clinical translation and reverse translation.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jose M. Horcas-Nieto, Christian J. Versloot, Miriam Langelaar-Makkinje, Albert Gerding, Tjasso Blokzijl, Mirjam H. Koster, Mirjam Baanstra, Ingrid A. Martini, Robert P. Coppes, Celine Bourdon, Sven C. D. van Ijzendoorn, Peter Kim, Robert H. J. Bandsma, Barbara M. Bakker
Summary: Hospitalized children with severe malnutrition often suffer from hepatic and intestinal dysfunction, leading to high mortality rates. Our study has established organoid models of severe malnutrition in the liver and intestine, which recapitulate the expected functional changes and protein alterations seen in these organs. By re-supplementing amino acids or using specific drugs, we observed partial recovery of organoid function. These organoid models serve as valuable tools for understanding the underlying mechanisms and testing potential treatments for intestinal and hepatic dysfunction in severe malnutrition.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Madelon J. H. Metman, Pascal K. C. Jonker, Luc H. J. Sondorp, Bettien M. van Hemel, Mark S. Sywak, Anthony J. Gill, Liesbeth Jansen, Paul J. van Diest, Tessa M. van Ginhoven, Clemens W. G. M. Lowik, Anh H. Nguyen, Dominic J. Robinson, Gooitzen M. van Dam, Thera P. Links, Rob P. Coppes, Rudolf S. N. Fehrmann, Schelto Kruijff
Summary: This study evaluated the use of EMI-137 targeted molecular fluorescence-guided imaging (MFGI) and spectroscopy as a tool for intra-operative detection of uni- and multifocal papillary thyroid cancer (PTC) to improve disease staging and treatment selection.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Meeting Abstract
Oncology
A. Soto Gamez, Y. Wu, X. Peng, S. Pringle, A. Vissink, L. Barazzuol, R. P. Coppes
RADIOTHERAPY AND ONCOLOGY
(2022)
