Article
Immunology
Megan Birkhold, Shrimati Datta, Gi Deok Pak, Justin Im, Olakayode O. Ogundoyin, Dare Olulana, Taiwo A. Lawal, Oludolapo O. Afuwape, Aderemi Kehinde, Marie-France Phoba, Gaelle Nkoji, Abraham Aseffa, Mekonnen Teferi, Biruk Yeshitela, Oluwafemi Popoola, Michael Owusu, Lady Rosny Wandji Nana, Enoch G. Cakpo, Moussa Ouedraogo, Edgar Ouangre, Isso Ouedraogo, Anne-Sophie Heroes, Jan Jacobs, Ondari D. Mogeni, Andrea Haselbeck, Leah Sukri, Kathleen M. Neuzil, Octavie Lunguya Metila, Ellis Owusu-Dabo, Yaw Adu-Sarkodie, Abdramane Soura Bassiahi, Raphael Rakotozandrindrainy, Iruka N. Okeke, Raphael M. Zellweger, Florian Marks
Summary: This study demonstrates that typhoid intestinal perforation (TIP) is the most serious complication of typhoid fever in certain regions of Burkina Faso, Democratic Republic of Congo, Ethiopia, Ghana, Madagascar, and Nigeria. Many cases of TIP may not be reported as typhoid due to limited diagnostic capabilities in these countries.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Summary: A trial conducted in low-income and middle-income countries did not demonstrate benefits of 2% alcoholic chlorhexidine skin preparation compared with povidone-iodine, or triclosan-coated sutures compared with non-coated sutures, in preventing surgical site infections in cleancontaminated or contaminated or dirty surgical wounds. Both interventions are more costly than alternatives, and these results do not endorse routine use.
Article
Surgery
Ya-Wen Hsiao, Chih-Yang Hsiao, John Huang, Peng-Sheng Lai, Po-Yen Chen
Summary: Patients in tertiary care hospitals had longer waiting time, higher risks of surgical delays, longer operation time, more appendix perforations, and higher hospital costs compared with the regional hospital group.
WORLD JOURNAL OF SURGERY
(2023)
Review
Public, Environmental & Occupational Health
Emmanuel Piednoir, Joan Robert-Yap, Patrice Baillet, Emilie Lermite, Niki Christou
Summary: Surgical site infections pose a significant economic burden, with costs varying depending on factors such as the patient and the type of surgery. Prevention of infections is a profitable concept for surgery and should be integrated into healthcare management globally.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Surgery
Nina S. Cohen, Jiselle M. Bock, Addison K. May
Summary: Surgical site infections are a significant cause of illness and death. There is strong evidence supporting several preventive measures, but their effective implementation is not optimal. It is crucial to identify high-risk patients and avoid pitfalls in diagnosing surgical site infections, especially in emergency surgery patients with physiological disorders. Maintaining a high level of suspicion after surgery is critical in identifying patients with surgical site infections and preventing failure to rescue.
Article
Surgery
Miho Shibamura-Fujiogi, Jennifer Ormsby, Mark Breibart, Jill Zalieckas, Thomas J. Sandora, Gregory P. Priebe, Koichi Yuki
Summary: This study investigated the association between sevoflurane dosage and surgical site infections in pediatric patients undergoing elective intestinal surgery. The findings revealed a correlation between higher sevoflurane doses and increased incidence of SSIs, which was further confirmed through multivariate regression analysis.
JOURNAL OF SURGICAL RESEARCH
(2021)
Review
Infectious Diseases
Biagio Pinchera, Antonio Riccardo Buonomo, Nicola Schiano Moriello, Riccardo Scotto, Riccardo Villari, Ivan Gentile
Summary: Surgical site infections are a growing concern in nosocomial infections. Antibiotic resistance, increasing surgical interventions, and patients' complex comorbidities contribute to this problem. It is important to consider all risk factors, preventive measures, and possible therapeutic interventions in managing surgical site infections.
Article
Medicine, General & Internal
Rami Sommerstein, Nicolas Troillet, Stephan Harbarth, Marlieke E. A. de Kraker, Danielle Vuichard-Gysin, Stefan P. Kuster, Andreas F. Widmer
Summary: This study aimed to evaluate the relationship between the timing of administration of cefuroxime surgical antimicrobial prophylaxis (SAP) and the occurrence of surgical site infections (SSI). The results showed that cefuroxime SAP should be administered within 60 minutes prior to incision, and ideally within 10 to 25 minutes, to reduce the risk of SSI.
Article
Surgery
Sungshin Na, Natale Mazzaferro, Weiyi Xia, Patricia Greenberg, William Beckerman
Summary: This study aimed to determine factors associated with an increased risk of developing postoperative SSI in patients undergoing lower extremity revascularization. Risk factors for SSI included age, body mass index, comorbidities, and procedure time. Patients who developed an SSI were more likely to have adverse outcomes such as myocardial infarction/stroke and major amputation.
ANNALS OF VASCULAR SURGERY
(2023)
Article
Health Care Sciences & Services
Maximilian Scheer, Kai Spindler, Christian Strauss, Stefan Schob, Christian T. Dietzel, Sandra Leisz, Julian Prell, Stefan Rampp
Summary: Surgical site infections (SSIs) after craniotomy are a significant concern for patients with glioblastoma, as they lead to increased morbidity, mortality, and healthcare costs. This study aimed to identify risk factors for SSIs in glioblastoma patients by analyzing patient data from 2012 to 2021. The results suggest that previous surgery, introduced foreign material, subgaleal suction drain, and ventricle opening may slightly increase the risk of SSIs, but none of these factors reached statistical significance. Surprisingly, patients who received radiation therapy had a significantly lower incidence of SSIs.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Engineering, Biomedical
Catalina Pineda Molina, George S. Hussey, Alvin Liu, Jonas Eriksson, William A. D'Angelo, Stephen F. Badylak
Summary: The study suggests that surgical meshes composed of naturally occurring materials, such as 4HB, can increase resistance to surgical site infections by activating molecular pathways promoting antimicrobial peptide expression. The findings provide insights into the mechanisms behind the decreased incidence of infections associated with the use of these meshes.
Review
Microbiology
Lieke ter Steeg, Jorge Dominguez-Andres, Mihai G. Netea, Leo A. B. Joosten, Reinout van Crevel
Summary: New strategies to prevent surgical site infections (SSIs) are crucial in combating health care-associated infections. Enhancing the function of innate immune cells through trained immunity may reduce the risk of SSIs by improving local host defense and preventing postoperative immunoparalysis.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Review
Gastroenterology & Hepatology
Amram Kupietzky, Roi Dover, Haggi Mazeh
Summary: Small intestinal neuroendocrine tumors (NETs) are a common type of epithelial tumors with neuroendocrine differentiation. They have been increasing in prevalence worldwide and often present with synchronous metastases due to delayed diagnosis. Primary tumor resection is the only curative option for small intestinal NETs. This review article discusses various surgical aspects for excising these tumors.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Surgery
Sanjiv K. Hyoju, Robert Keskey, Gerardo Castillo, Kaylie Machutta, Alexander Zaborin, Olga Zaborina, John C. Alverdy
Summary: Pi-PEG is effective in preventing surgical site infection caused by gut-derived pathogens. In a mouse model, it was found that Pi-PEG added to drinking water protected against SSIs through modulation of the gut-wound microbiome.
Article
Pharmacology & Pharmacy
Sunitha Sampathi, Pankaj Kumar Tiriya, Sujatha Dodoala, Vijayabhaskarreddy Junnuthula, Sathish Dyawanapelly
Summary: This study developed ciprofloxacin hydrochloride-loaded gold nanoparticles and coated them onto sterile surgical sutures using an adsorption technique followed by ionotropic crosslinking. The drug-coupled nanoparticle-laden sutures showed enhanced antibacterial properties and prolonged drug release, indicating their potential as a clinical option for preventing surgical site infections.
Article
Surgery
Lucas C. Carlson, Joseph A. Lin, Emmanuel A. Ameh, Wakisa Mulwafu, Peter Donkor, Miliard Derbew, Edgar Rodas, Nyengo C. Mkandawire, Mitra Dhanaraj, Herve Yangni-Angate, Rachid Sani, Mohamed Labib, Roxana Barbero, Damian Clarke, Martin D. Smith, Lawrence Sherman, Frederick A. Mutyaba, Philip Alexander, Larry G. P. Hadley, Michael J. VanRooyen, Adam L. Kushner
WORLD JOURNAL OF SURGERY
(2015)
Article
Obstetrics & Gynecology
Emmanuel A. Ameh, Philip M. Mshelbwala, Nkeiruka Ameh
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2011)
Article
Pediatrics
Lohfa B. Chirdan, Emmanuel A. Ameh, Francis A. Abantanga, Daniel Sidler, Essam A. Elhalaby
JOURNAL OF PEDIATRIC SURGERY
(2010)
Review
Medicine, General & Internal
Adamu Ahmed, Mairo Adamu Bugaje, Ahmadu Aliyu Babadoko, Emmanuel Ameh
JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
(2012)
Editorial Material
Medicine, General & Internal
Lohfa B. Chirdan, Emmanuel A. Ameh
Review
Pediatrics
Abdulrasheed A. Nasir, Emmanuel A. Ameh, Lukman O. Abdur-Rahman, James O. Adeniran, Mohan K. Abraham
WORLD JOURNAL OF PEDIATRICS
(2011)
Article
Surgery
Mekam T. Okoye, Emmanuel A. Ameh, Adam L. Kushner, Benedict C. Nwomeh
WORLD JOURNAL OF SURGERY
(2015)
Editorial Material
Surgery
Marilyn W. Butler, Doruk Ozgediz, Dan Poenaru, Emmanuel Ameh, Safwat Andrawes, Georges Azzie, Eric Borgstein, Daniel A. DeUgarte, Essam Elhalaby, Michael E. Ganey, J. Ted Gerstle, Erik N. Hansen, Afua Hesse, Kokila Lakhoo, Sanjay Krishnaswami, Monica Langer, Marc Levitt, Don Meier, Ashish Minocha, Benedict C. Nwomeh, Lukman O. Abdur-Rahman, David Rothstein, John Sekabira
WORLD JOURNAL OF SURGERY
(2015)
Article
Pediatrics
C. S. Lukong, E. A. Ameh, P. M. Mshelbwala, B. A. Jabo, A. Gomna, M. A. Anumah, P. T. Nmadu, A. Y. Mfuh
JOURNAL OF PEDIATRIC UROLOGY
(2014)
Article
Medicine, General & Internal
Kelsey Landrum, Cesia F. Cotache-Condor, Yingling Liu, Paul Truche, Julia Robinson, Nealey Thompson, Ryann Granzin, Emmanuel Ameh, Steve Bickler, Lubna Samad, John G. Meara, Henry E. Rice, Emily R. Smith
Summary: The study evaluates the priority given to surgical care for children within national health policies, strategies and plans. Analysis of NHPSPs found that only 7% discussed children's surgery, with most countries not mentioning essential children's procedures. The low prevalence of children's surgical terms in NHPSPs indicates a need for increased awareness and inclusion in national health plans to scale up surgical care for children in these countries.
Article
Public, Environmental & Occupational Health
Mohamed Abd Salam El Vilaly, Maureen A. Jones, Makela Cordero Stankey, Justina Seyi-Olajide, Bisola Onajin-Obembe, Andat Dasogot, Stefanie J. Klug, John Meara, Emmanuel A. Ameh, Olabisi O. Osagie, Sabrina Juran
Summary: The study aimed to assess the percentage of Nigerian youth who have access to paediatric surgical care within 2 hours, revealing significant disparities across the country with only a few states having a considerable portion of their population living within the 2-hour travel time to medical facilities.
Review
Public, Environmental & Occupational Health
Lotta Velin, Adam Lantz, Emmanuel A. Ameh, Nobhojit Roy, Desmond T. Jumbam, Omolara Williams, Alex Elobu, Justina Seyi-Olajide, Lars Hagander
Summary: The study presents the perceptions of LMIC stakeholders on visiting surgical teams from high-income countries. The advantages of these visits include meeting clinical care needs, improving skills, strengthening healthcare systems, academic and career benefits, and collaboration opportunities. On the other hand, disadvantages include poor quality of care, lack of follow-up, insufficient knowledge transfer, ethical and equity dilemmas, competition, administrative and financial issues, and language barriers.
Article
Medicine, General & Internal
Sabrina Wimmer, Paul Truche, Elena Guadagno, Emmanuel Ameh, Lubna Samad, Emmanuel Mwenda Malabo Makasa, Sarah Greenberg, John G. Meara, Tonnis H. van Dijk, Dan Poenaru
Summary: This study aims to assess the inclusion of children's surgical care among existing NSOAPs, identify practice examples, and provide recommendations for future policies. It found that there is a lack of attention to children's surgery in low/middle-income countries (LMICs) and recommends focusing on the development of surgical healthcare systems for children.
Article
Pediatrics
Ibukunolu Olufemi Ogundele, Felix M. Alakaloko, Collins C. Nwokoro, Emmanuel A. Ameh
BMJ PAEDIATRICS OPEN
(2020)