GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses

Regulatory B Cells: Origin, Phenotype, and Function

(2015) Elizabeth C. Rosser et al.   IMMUNITY

Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses

(2014) Sam X. Cheng et al.   FEBS LETTERS

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Alum Directly Modulates Murine B Lymphocytes to Produce IgG1 Isotype

(2013) Bo-Ra Jin et al.   Immune Network

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

(2012) Manuela Rossol et al.   Nature Communications

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

(2011) Etsushi Kuroda et al.   IMMUNITY

Regulatory B10 Cells Differentiate into Antibody-Secreting Cells After Transient IL-10 Production In Vivo

(2011) D. Maseda et al.   JOURNAL OF IMMUNOLOGY

DNA released from dying host cells mediates aluminum adjuvant activity

(2011) Thomas Marichal et al.   NATURE MEDICINE

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

(2011) Tracy L Flach et al.   NATURE MEDICINE

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

(2011) A. Seubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor

(2009) Helene Faure et al.   CELL CALCIUM

Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity

(2009) A. S. McKee et al.   JOURNAL OF IMMUNOLOGY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity

(2008) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions

(2008) Petrine Wellendorph et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY