Review
Cell Biology
Trisha A. Macrae, Julie Fothergill-Robinson, Miguel Ramalho-Santos
Summary: Cells differentiate and progress through development guided by a dynamic chromatin landscape that mediates gene expression programmes. The bivalent chromatin state, characterized by both gene activation and repression histone modifications, is crucial for cell lineage specification. Recent research has provided new insights into the molecular basis of bivalent chromatin and its roles in development and cancer.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Chao Liu, Lingang Sun, Yijun Tan, Qi Wang, Tao Luo, Chenlu Li, Nan Yao, Yuting Xie, Xiao Yi, Yi Zhu, Tiannan Guo, Junfeng Ji
Summary: USP7 plays an important role in maintaining the identity of mouse embryonic stem cells (mESCs) by regulating the transcriptional network. It represses lineage differentiation genes through both catalytic activity-dependent and -independent mechanisms, and stabilizes the transcription factor SOX2 to suppress the expression of mesoendodermal lineage genes. Additionally, it contributes to Polycomb chromatin-mediated repression of lineage genes.
Article
Biochemistry & Molecular Biology
Dhirendra Kumar, Senthilkumar Cinghu, Andrew J. Oldfield, Pengyi Yang, Raja Jothi
Summary: Bivalent chromatin does not rapidly activate genes but protects them from de novo DNA methylation. The activation of bivalent genes in differentiating ESCs is not faster than other silent genes, challenging the instructive role of H3K4me3 in transcription. Loss of H3K4me3 may make bivalent genes more susceptible to aberrant DNA methylation in diseases like cancer.
Article
Green & Sustainable Science & Technology
Naveenarani Murugan, Ravinder Kumar, Shashi Kant Pandey, Pooja Dhansu, Mahadevaiah Chennappa, Saranya Nallusamy, Hemaprabha Govindakurup, Appunu Chinnaswamy
Summary: This study investigated the characteristics and regulatory mechanisms of phosphate transporter gene promoters through computer analysis. It found that one of the gene promoters can enhance gene expression under salt stress conditions, which is of great significance for the development of salt-tolerant transgenic crops.
Review
Cell & Tissue Engineering
Yixuan Low, Dennis Eng Kiat Tan, Zhenhua Hu, Shawn Ying Xuan Tan, Wee-Wei Tee
Summary: Retrotransposons have specific expression dynamics during early mammalian development, linked to the establishment of totipotency, with the significance of their transcriptional activities during this process still being uncovered.
STEM CELLS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Angeles Arzalluz-Luque, Guillaume Devailly, Anna Mantsoki, Anagha Joshi
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2017)
Article
Developmental Biology
Anna Mantsoki, Guillaume Devailly, Anagha Joshi
BMC DEVELOPMENTAL BIOLOGY
(2018)
Article
Cell Biology
Linda Sutherland, Madeleine Ruhe, Daniela Gattegno-Ho, Karanjit Mann, Jennifer Greaves, Magdalena Koscielniak, Stephen Meek, Zen Lu, Martin Waterfall, Ryan Taylor, Anestis Tsakiridis, Helen Brown, Sutherland K. Maciver, Anagha Joshi, Michael Clinton, Luke H. Chamberlain, Austin Smith, Tom Burdon
JOURNAL OF CELL SCIENCE
(2018)
Article
Biochemical Research Methods
Guillaume Devailly, Anagha Joshi
BMC BIOINFORMATICS
(2018)
Article
Biochemistry & Molecular Biology
Deepti Vipin, Lingfei Wang, Guillaume Devailly, Tom Michoel, Anagha Joshi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Review
Genetics & Heredity
Julia Romanowska, Anagha Joshi
Article
Cell & Tissue Engineering
Stephen Meek, Jun Wei, Taeho Oh, Tom Watson, Jaime Olavarrieta, Linda Sutherland, Daniel F. Carlson, Angela Salzano, Tamir Chandra, Anagha Joshi, Tom Burdon
Article
Biochemistry & Molecular Biology
Guillaume Devailly, Anagha Joshi
Summary: Advances in sequencing technologies have enabled exploration of epigenetic and transcriptional profiles at a genome-wide level, with many studies utilizing these datasets for multi-omics analyses; while most studies have focused on promoters/enhancers and transcription start sites, other features of transcription control remain underexplored; through comprehensive analysis of thirty-three human cell lines and tissue types, new hypotheses about the interplay between epigenetic modifications and transcription features have been generated.
Proceedings Paper
Engineering, Biomedical
Guillaume Devailly, Anagha Joshi
BIOINFORMATICS AND BIOMEDICAL ENGINEERING, IWBBIO 2017, PT II
(2017)
Article
Biotechnology & Applied Microbiology
Bruno Giotti, Anagha Joshi, Tom C. Freeman