Review
Medicine, General & Internal
Jeremy McGale, Sakshi Khurana, Alice Huang, Tina Roa, Randy Yeh, Dorsa Shirini, Parth Doshi, Abanoub Nakhla, Maria Bebawy, David Khalil, Andrew Lotfalla, Hayley Higgins, Amit Gulati, Antoine Girard, Francois-Clement Bidard, Laurence Champion, Phuong Duong, Laurent Dercle, Romain-David Seban
Summary: HER2-positive breast cancer, characterized by amplification of the HER2 gene, is associated with aggressive tumor growth, increased metastatic risk, and poorer prognosis compared to other subtypes. HER2 expression is a crucial tumor feature for breast cancer diagnosis and treatment. Advancements in HER2 in vivo imaging techniques like PET and SPECT may enhance the role of HER2 status in guiding breast cancer management, enabling determination of tumor size, location, and evaluation of treatment effectiveness. This review explores the current and future role of HER2 imaging in personalized care for breast cancer patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Salvio Suarez-Garcia, Tullio V. F. Esposito, Jenna Neufeld-Peters, Marta Bergamo, Hua Yang, Katayoun Saatchi, Paul Schaffer, Urs O. Hafeli, Daniel Ruiz-Molina, Cristina Rodriguez-Rodriguez, Fernando Novio
Summary: Metal-phenolic nanoparticles (MPNs) fabricated with a coordination polymer core and a phenolic-based coating show promise for preclinical imaging studies. These versatile nanoparticles, with effective hydrodynamic diameters of around 120 nm, can be further derivatized for in vivo targeting and functionalization. Incorporating trace amounts of radioactive metals In-111 or Cu-64 allows for in vivo imaging using single-photon emission computed tomography (SPECT) and positron emission tomography (PET) in tumor-bearing mice, demonstrating the potential of MPNs as multimodal preclinical imaging agents.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Medicine, Research & Experimental
Huiling Li, Yihan Chen, Qiaofeng Jin, Ya Wu, Cheng Deng, Yongkang Gai, Zhenxing Sun, Yuman Li, Jing Wang, Yali Yang, Qing Lv, Yongxue Zhang, Rui An, Xiaoli Lan, Li Zhang, Mingxing Xie
Summary: The study developed a radiolabeled probe Tc-99m-HYNIC-mAb(CD4) for visualization of CD4+ T lymphocyte infiltration and detection of acute rejection after heart transplantation, showing high affinity and specificity for binding to CD4+ T lymphocytes.
MOLECULAR PHARMACEUTICS
(2021)
Article
Medicine, Research & Experimental
Yingying Zhang, Ying Ding, Ning Li, Sen Wang, Si Zhou, Ruping Li, Hui Yang, Wenliang Li, Jinrong Qu
Summary: Programmed cell death protein-1/ligand-1 (PD-1/PD-L1) checkpoint blockade is a major breakthrough in cancer therapy, but identifying patients likely to benefit from this therapy remains challenging. Noninvasive SPECT imaging with radiolabeled PD-L1 antibody may provide a solution by allowing the assessment of PD-L1 expression throughout the whole body.
MOLECULAR PHARMACEUTICS
(2023)
Article
Surgery
Sujata Saha, Robert A. Vierkant, Geoffrey B. Johnson, Ahmad Parvinian, Robert A. Wermers, Trenton Foster, Travis McKenzie, Benzon Dy, Melanie Lyden
Summary: C-11 choline positron emission tomography/computed tomography can be a useful adjunct for parathyroid localization in cases of nonlocalized primary hyperparathyroidism. The study shows that it has a sensitivity of 64% and a positive predictive value of 72%.
Review
Physics, Multidisciplinary
Gabriela Llosa, Magdalena Rafecas
Summary: Compton cameras have advantages over gamma cameras in certain applications, especially for multitracer imaging and high-energy radiotracer imaging in radionuclide therapy. Although they cannot compete with PET and SPECT in conventional clinical settings, there are specific scenarios where they can be a beneficial alternative. Combining PET and Compton imaging can improve resolution and sensitivity while overcoming limitations of PET in using multiple radiotracers. Advances are being made in both instrumentation development and image reconstruction to address the challenges of combining these two modalities.
EUROPEAN PHYSICAL JOURNAL PLUS
(2023)
Article
Medicine, General & Internal
Xuan Jin, Eun-Ju Kang, Cai-De Jin, Kwang-Min Lee, Kyung-Hee Lim, Seung-Woon Rha, Cheol-Ung Choi, Hwan-Seok Yong, Sung-Cheol Yun, Matthew J. Budoff, Long-Hao Yu, Moo-Hyun Kim
Summary: This study found that dual-acquisition CCTA can support the non-invasive detection of vasospastic angina with relatively good specificity and positive predictive value (PPV).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Joseph A. Frankl, Yu An, Amber Sherwood, Guiyang Hao, Feng-Yun Huang, Pawan Thapa, Deborah J. Clegg, Xiankai Sun, Philipp E. Scherer, Orhan K. Oz
Summary: Obesity is a leading cause of preventable death and morbidity. This study finds that imaging BAT with the radioiodinated fatty acid analogue BMIPP yields more physiologically relevant data than FDG-PET/CT and may be a pivotal tool for evaluating BAT in both mice and humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Mirela Gherghe, Mario-Demian Mutuleanu, Adina Elena Stanciu, Ionela Irimescu, Alexandra Maria Lazar, Radu Valeriu Toma, Oana Gabriela Trifanescu, Rodica Maricela Anghel
Summary: By quantitatively interpreting SPECT-CT images, we can better demonstrate changes in radiotracer uptake between baseline and follow-up scans in breast cancer patients with metastatic bone disease, compared to qualitative assessment. This method provides a standardized and robust approach for patient follow-up evaluation, which is particularly important for research purposes.
Article
Endocrinology & Metabolism
Muhammad Fauzi, Takaaki Murakami, Hiroyuki Fujimoto, Ainur Botagarova, Kentaro Sakaki, Sakura Kiyobayashi, Masahito Ogura, Nobuya Inagaki
Summary: Assessment of beta-cell mass (BCM) in a noninvasive way is crucial for diabetes research. This study investigates the effects of imeglimin treatment on prediabetic db/db mice and finds that imeglimin can attenuate the progression of glucose intolerance, preserve more beta cells, inhibit beta-cell apoptosis, and improve mitochondrial function and islet structure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tess Reynolds, Owen Dillon, Joseph Prinable, Brendan Whelan, Paul J. Keall, Ricky T. O'Brien
Summary: The study compared ACROBEAT with a conventional cardiac CBCT imaging protocol, showing that ACROBEAT provides higher quality images while reducing the total number of acquired projections by 90%, independent of the patient's heart rate.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Xuezhu Wang, Yining Wang, Jian Li, Li Huo, Shuyang Zhang
Summary: The study shows that Tc-99m-PYP scintigraphy and C-11-PIB PET/CT can differentiate between two major types of cardiac amyloidosis noninvasively, offering potential benefits for clinical diagnosis and treatment.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Biochemical Research Methods
Martina Sollini, Luca Cozzi, Gaia Ninatti, Lidija Antunovic, Lara Cavinato, Arturo Chiti, Margarita Kirienko
Summary: The review assesses the status of PET/CT radiomics in breast cancer, finding that current evidence is at feasibility level and recommends harmonized methods and transparent reporting to improve validity and generalizability of results.
Review
Biochemistry & Molecular Biology
Olga Krasnovskaya, Aina Kononova, Alexander Erofeev, Peter Gorelkin, Alexander Majouga, Elena Beloglazkina
Summary: There are over 55 million people with dementia worldwide and nearly 10 million new cases every year. Alzheimer's disease is the most common neurodegenerative disease that causes personality changes, cognitive impairment, memory loss, and physical disability. Early detection methods are important for early treatment of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alan C. Kwan, Amir Pourmorteza, Dan Stutman, David A. Bluemke, Joao A. C. Lima
Summary: Impending major hardware advances in cardiac CT include ultra-high-resolution (UHR) CT, photon-counting CT, and phase-contrast CT, which improve visualization and contrast resolution but may also introduce increased noise and radiation exposure.
Article
Clinical Neurology
Jose Miguel Spirig, Martin Huellner, Frederic Cornaz, Michael Betz, Florian Wanivenhaus, Marlena Hofbauer, Anass Johayem, Philipp A. Kaufmann, Mazda Farshad
Summary: This study compared the effectiveness of [18F]-sodium fluoride (NaF) PET/MR with the standard of care in detecting painful facet joints. The results showed that there was no significant superiority of [18F]-NaF PET/MR over the standard care in identifying painful facet joints.
Article
Cardiac & Cardiovascular Systems
Susan Bengs, Geoffrey Warnock, Angela Portmann, Nidaa Mikail, Alexia Rossi, Hazem Ahmed, Dominik Etter, Valerie Treyer, Livio Gisler, Stefanie K. Pfister, Caitlin V. M. L. Jie, Alexander Meisel, Claudia Keller, Steven H. Liang, Roger Schibli, Linjing Mu, Ronny R. Buechel, Philipp A. Kaufmann, Simon M. Ametamey, Catherine Gebhard, Ahmed Haider
Summary: This study demonstrates the feasibility of using F-18-flurpiridaz for simplified assessment of relative myocardial perfusion and coronary flow reserve in mice, enabling high-throughput mechanistic CFR studies in rodents.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas A. Giannopoulos, Ronny R. Buechel, Philipp A. Kaufmann
Summary: This article summarizes the current research on coronary microvascular dysfunction in pathologic hypertrophy.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander Maurer, Aleksandra Sustar, Andreas A. Giannopoulos, Hannes Gruenig, Adam Bakula, Dimitri Patriki, Elia von Felten, Michael Messerli, Aju P. Pazhenkottil, Catherine Gebhard, Philipp A. Kaufmann, Ronny R. Buechel, Tobias A. Fuchs
Summary: In this study, a comparison was made between [N-13]-ammonia-PET and cardiac magnetic resonance (CMR) in evaluating left ventricular volumes and function. The results indicate that LVEF and LV wall motion can be accurately assessed using [N-13]-ammonia-PET, although LV volumes are significantly underestimated compared to CMR.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Immunology
Isabella C. Schoepf, Christian W. Thorball, Helen Kovari, Bruno Ledergerber, Ronny R. Buechel, Alexandra Calmy, Rainer Weber, Philipp A. Kaufmann, Rene Nkoulou, Johannes M. Schwenke, Dominique L. Braun, Jacques Fellay, Philip E. Tarr
Summary: In Swiss HIV-infected individuals, subclinical coronary artery disease is independently associated with an individual polygenic risk score for coronary artery disease. Combining non-genetic and genetic cardiovascular risk factors provides the most powerful prediction for subclinical coronary artery disease.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Robert J. H. Miller, Ananya Singh, Yuka Otaki, Balaji K. Tamarappoo, Paul Kavanagh, Tejas Parekh, Lien-Hsin Hu, Heidi Gransar, Tali Sharir, Andrew J. Einstein, Mathews B. Fish, Terrence D. Ruddy, Philipp A. Kaufmann, Albert J. Sinusas, Edward J. Miller, Timothy M. Bateman, Sharmila Dorbala, Marcelo F. Di Carli, Joanna X. Liang, Damini Dey, Daniel S. Berman, Piotr J. Slomka
Summary: This study evaluated different strategies for training AI models in order to improve the calibration and diagnostic accuracy for coronary artery disease (CAD). The results showed that training the models with augmentation of low-risk patients led to better calibration and higher accuracy, particularly in women.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Ananya Singh, Robert J. H. Miller, Yuka Otaki, Paul Kavanagh, Michael T. Hauser, Evangelos Tzolos, Jacek Kwiecinski, Serge Van Kriekinge, Chih-Chun Wei, Tali Sharir, Andrew J. Einstein, Mathews B. Fish, Terrence D. Ruddy, Philipp A. Kaufmann, Albert J. Sinusas, Edward J. Miller, Timothy M. Bateman, Sharmila Dorbala, Marcelo Di Carli, Joanna X. Liang, Cathleen Huang, Donghee Han, Damini Dey, Daniel S. Berman, Piotr J. Slomka
Summary: This study developed an explainable deep learning model for predicting death or nonfatal myocardial infarction in myocardial perfusion imaging (MPI). The model improves prediction accuracy by assessing patient-level risk.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Juhwan Lee, Kashif Shaikh, Rine Nakanishi, Heidi Gransar, Stephan Achenbach, Mouaz H. Al-Mallah, Daniele Andreini, Jeroen J. Bax, Daniel S. Berman, Filippo Cademartiri, Tracy Q. Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J. W. Chow, Ricardo C. Cury, Augustin DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A. Kaufmann, Yong-Jin Kim, Jonathon A. Leipsic, Erica Maffei, Hugo Marques, Pedro de Araujo Goncalves, Gianluca Pontone, Ronen Rubinshtein, Todd C. Villines, Yao Lu, Jessica M. Pena, Fay Y. Lin, James K. Min, Leslee J. Shaw, Matthew J. Budoff
Summary: This study investigated the relationship between non-obstructive left main (LM) disease, diabetes mellitus (DM), and all-cause mortality (ACM). The results showed that while DM was associated with increased ACM, the presence of non-obstructive LM disease was not an independent risk factor for ACM.
HEART LUNG AND CIRCULATION
(2023)
Article
Cardiac & Cardiovascular Systems
Ganna Degtiarova, Chrysoula Garefa, Reto Boehm, Domenico Ciancone, Daniel Sepulcri, Catherine Gebhard, Andreas A. Giannopoulos, Aju P. Pazhenkottil, Philipp A. Kaufmann, Ronny R. Buechel
Summary: This study found that a radiomic feature (GLRLM_GLNU) extracted from visually normal 13N-ammonia PET retention images can independently predict reduced global myocardial flow reserve. This concept could potentially be applied to other myocardial perfusion imaging modalities based on relative distribution patterns to improve the detection of diffuse disease.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Imaging Science & Photographic Technology
Markus Jehl, Ekaterina Mikhaylova, Valerie Treyer, Marlena Hofbauer, Martin Huellner, Philipp A. Kaufmann, Alfred Buck, Geoff Warnock, Viet Dao, Charalampos Tsoumpas, Daniel Deidda, Kris Thielemans, Max Ludwig Ahnen, Jannis Fischer
Summary: NeuroLF is a dedicated brain PET system with an octagonal prism shape that can be positioned around a patient's head. Attenuation correction is crucial since it lacks MR or CT capabilities.
JOURNAL OF IMAGING
(2023)
Article
Peripheral Vascular Disease
Andreas A. Giannopoulos, Basil Bolt, Dominik C. Benz, Michael Messerli, Elia Von Felten, Dimitri Patriki, Catherine Gebhard, Aju P. Pazhenkottil, Christoph Grani, Philipp A. Kaufmann, Ronny R. Buechel, Oliver Gaemperli
Summary: Myocardial bridging (MB) is a segment of coronary arteries that is usually free from atherosclerosis, while the adjacent proximal segment is prone to it due to local endothelial shear stress (ESS). This study used coronary computed tomography angiography and computational fluid dynamics to analyze the ESS in coronary arteries with MBs and investigate the association between atherosclerosis and hemorheological characteristics. The results showed that there was no significant difference in ESS between the proximal 5 mm to MBs and the region within MBs. No significant ESS variances were observed around the MB entrance in arteries with plaques, regardless of the morphological features of the bridged segment. MBs have homogeneous, atheroprotective ESS, which may explain the absence of atherosclerosis within bridged segments. The interplay between ESS and atherosclerosis is potentially similar in arteries with MB compared to those without bridges.
Review
Cardiac & Cardiovascular Systems
Thomas H. Schindler, William F. Fearon, Matthieu Pelletier-Galarneau, Giuseppe Ambrosio, Udo Sechtem, Terrence D. Ruddy, Krishna K. Patel, Deepak L. Bhatt, Timothy M. Bateman, Henry Gewirtz, Jamshid Shirani, Juhani Knuuti, Robert J. Gropler, Panithaya Chareonthaitawee, Riemer H. J. A. Slart, Stephan Windecker, Philipp A. Kaufmann, Maria R. Abraham, Viviany R. Taqueti, Thomas J. Ford, Paolo G. Camici, Heinrich R. Schelbert, Vasken Dilsizian
Summary: Diagnosing angina pectoris and dyspnea in patients with normal or nonobstructive coronary vessels is challenging. Invasive coronary angiography can identify nonobstructive coronary artery disease, but coronary microvascular dysfunction may actually be the cause of symptoms. Positron emission tomography (PET) allows noninvasive detection and delineation of coronary microvascular dysfunction by quantifying myocardial blood flow at rest and during vasodilation. Individualized or intensified medical therapies may improve symptoms, quality of life, and outcomes. Standardized diagnosis and reporting criteria for ischemic symptoms caused by coronary microvascular dysfunction are crucial for treatment decisions. A consensus document proposes standardized diagnosis, nomenclature, and reporting criteria for coronary microvascular dysfunction. It aims to provide an overview of its pathophysiology, assessment, and classification, which are essential for diagnosis, patient care, and clinical trials. (J Am Coll Cardiol Img 2023;16:536-548) (c) 2023 by the American College of Cardiology Foundation.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dominik Etter, Geoff Warnock, Frederic Koszarski, Tilo Niemann, Nidaa Mikail, Susan Bengs, Ronny. R. R. Buechel, Philipp Kaufmann, Catherine Gebhard, Alexia Rossi
Summary: This study aimed to investigate the impact of tube voltage and iterative reconstruction on the mean attenuation of pericoronary adipose tissue (PCAT(MA)) derived from coronary computed tomography angiography (CCTA). It was found that both tube voltage and reconstruction type significantly affected PCAT(MA), and it is recommended to use the same tube voltage and reconstruction type in multicenter and longitudinal studies.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexia Rossi, Antonio G. Gennari, Dominik Etter, Dominik C. Benz, Thomas Sartoretti, Andreas A. Giannopoulos, Nidaa Mikail, Susan Bengs, Alexander Maurer, Catherine Gebhard, Ronny R. Buechel, Philipp A. Kaufmann, Tobias A. Fuchs, Michael Messerli
Summary: Deep learning image reconstruction (DLIR) systematically underestimates Agatston coronary artery calcium (CAC) score, suggesting caution in its use for cardiovascular risk assessment.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Praveen Indraratna, Christopher Naoum, Sagit Ben Zekry, Heidi Gransar, Philipp Blanke, Stephanie Sellers, Stephan Achenbach, Mouaz H. Al-Mallah, Daniele Andreini, Daniel S. Berman, Matthew J. Budoff, Filippo Cademartiri, Tracy Q. Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J. W. Chow, Ricardo C. Cury, Augustin DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A. Kaufmann, Yong-Jin Kim, Erica Maffei, Hugo Marques, Pedro de Araujo Goncalves, Gianluca Pontone, Gilbert L. Raff, Ronen Rubinshtein, Todd C. Villines, Fay Y. Lin, Leslee J. Shaw, Jagat Narula, Jeroen J. Bax, Jonathon A. Leipsic
Summary: This cohort study analyzed 5-year data from an international registry to investigate the associations between baseline aspirin and statin use and mortality, major adverse cardiovascular events, and myocardial infarction in individuals without substantial stenosis. The results showed that in nonobstructive CAD, baseline statin use was associated with improved clinical outcomes, while baseline aspirin use was not.
RADIOLOGY-CARDIOTHORACIC IMAGING
(2022)