Article
Multidisciplinary Sciences
Garrett A. Roberts Kingman, Deven N. Vyas, Felicity C. Jones, Shannon D. Brady, Heidi I. Chen, Kerry Reid, Mark Milhaven, Thomas S. Bertino, Windsor E. Aguirre, David C. Heins, Frank A. von Hippel, Peter J. Park, Melanie Kirch, Devin M. Absher, Richard M. Myers, Federica Di Palma, Michael A. Bell, David M. Kingsley, Krishna R. Veeramah
Summary: This study explores the repeated evolution in stickleback to identify key genomic loci that change during colonization of freshwater habitats by marine fish, showing rapid genotypic and phenotypic changes within 5 years. The speed and location of these changes can be predicted using empirical observations or fundamental genomic features, suggesting the importance of similar features for evolution across diverse taxa.
Review
Ophthalmology
Yu Huang, Carol Y. Cheung, Dawei Li, Yih Chung Tham, Bin Sheng, Ching Yu Cheng, Ya Xing Wang, Tien Yin Wong
Summary: Cardiovascular disease (CVD) is a major cause of death globally, and the use of artificial intelligence (AI) in analyzing ocular images has the potential to enhance CVD risk prediction. This review provides an overview of AI-based ocular image analysis for predicting CVD and discusses the limitations in AI research and the challenges in clinical practice.
Review
Oncology
Fang-Ying Chiu, Yun Yen
Summary: Biomarker discovery and development play a crucial role in diagnosing diseases, particularly cancer. Imaging biomarkers provide objective information about tumor biology and its environment, aiding in treatment and diagnosis. Neuro-oncology has seen advancements in tumor classification and targeted therapies. The use of biomarkers and diagnostic tools in assessing prognosis and long-term effects is crucial, as is the implementation of personalized precision medicine.
BIOMARKER RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Jing Zhao, Cong Wang, Wanbing Sun, Cong Li
Summary: Excising epileptic foci (EF) is the most efficient approach for treating drug-resistant epilepsy (DRE), but accurate localization of EF is challenging. Finding biomarkers that represent the status of epilepsy and developing probes with high targeting specificity are important for identifying concealed EF. This review summarizes potential biomarkers of EF and classifies them into functional, molecular, and structural aberrances. It also highlights the materials used in fabricating imaging probes and their performance in preclinical and clinical studies. The review discusses perspectives on developing the next generation of probes and the challenges in clinical translation.
ADVANCED MATERIALS
(2022)
Review
Medicine, Research & Experimental
Zhang Ludi, Ashita Ashish Sule, Ramar Perumal Samy, Ikhwanuliman Putera, Benjamin Schrijver, Paul Edward Hutchinson, Jayantha Gunaratne, Indu Verma, Amit Singhal, Rina La Distia Nora, P. Martin van Hagen, Willem A. Dik, Vishali Gupta, Rupesh Agrawal
Summary: The purpose of this study was to summarize existing diagnostic approaches and recently discovered biomarkers for ocular tuberculosis (OTB). The study found that interferon-gamma release assay (IGRA) has better sensitivity and specificity than tuberculin skin test (TST). In addition, nucleic acid amplification tests (NAATs) showed improved specificity but variable sensitivity. Several potential biomarkers were also discovered, but further validation studies are needed.
Review
Medicine, General & Internal
Laura Teodoriu, Letitia Leustean, Maria-Christina Ungureanu, Stefana Bilha, Irena Grierosu, Mioara Matei, Cristina Preda, Cipriana Stefanescu
Summary: Personalized diagnosis using a combination of imagery, molecular biomarkers, and artificial intelligence algorithms can prevent unnecessary thyroid surgeries. Functional imaging diagnosis is widely used in thyroid nodules and can accurately diagnose malignant tumors. This personalized approach can avoid surgery complications and offset expensive diagnostic costs.
Review
Biochemistry & Molecular Biology
Farah Omran, Ioannis Kyrou, Faizel Osman, Ven Gee Lim, Harpal Singh Randeva, Kamaljit Chatha
Summary: Cardiovascular diseases (CVDs) are a major healthcare burden worldwide. Early detection is crucial for prevention and treatment, and biomarkers play a critical role. Traditional cardiac biomarkers have been replaced by new ones, but their limitations remain. Further research is needed to evaluate the value of future cardiac biomarkers in improving CVD detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lola Llobat, Olivia Gourbault
Summary: Osteosarcoma is a rare but highly deadly cancer, especially among children and adolescents. The discovery of miRNAs holds potential for earlier diagnosis, prognosis prediction, and development of new therapies for various types of tumors, including OS. The number of clinical trials involving miRNAs as prognostic and diagnostic biomarkers, as well as therapeutic targets, is likely to increase in the near future.
Article
Oncology
Xiaojuan Zhao, Ruben Y. Gabriels, Wouter T. R. Hooghiemstra, Marjory Koller, Gert Jan Meersma, Manon Buist-Homan, Lydia Visser, Dominic J. Robinson, Anna Tenditnaya, Dimitris Gorpas, Vasilis Ntziachristos, Arend Karrenbeld, Gursah Kats-Ugurlu, Rudolf S. N. Fehrmann, Wouter B. Nagengast
Summary: This study aimed to identify target proteins suitable for fluorescence molecular endoscopy (FME) in differentiating dysplastic Barrett's esophagus (DBE) from non-dysplastic Barrett's esophagus (NDBE). SPARC, SULF1, PKC iota, and DDR1 were identified as promising imaging targets, and near-infrared fluorescent tracers SULF1-800CW and SPARC-800CW were successfully developed for endoscopic imaging of DBE tissue.
Review
Cell Biology
Yujie Zhang, Yuxin Zhang, Lin Peng, Li Zhang
Summary: Esophageal cancer is a malignant tumor with poor prognosis in China. Surgery is the main treatment method, especially for early and mid-stage patients, to achieve radical cure. However, the high recurrence and metastasis risk of esophageal cancer remains a challenge after surgery.
Review
Oncology
Liliana Ascione, Edoardo Crimini, Dario Trapani, Antonio Marra, Carmen Criscitiello, Giuseppe Curigliano
Summary: Antibody-drug conjugates (ADCs) are a key treatment for many cancers, delivering cytotoxic drugs to tumor cells by binding to a target on the cell membrane. The presence of a specific target antigen has long been considered crucial for the use of ADCs, but some ADCs can be used without specific biomarkers. This article explores the role of target antigens in predicting response to ADCs and the need for new biomarkers to guide their use. It also discusses new methods for assessing and quantifying target expression to improve biomarker analysis.
Review
Oncology
Mehmet Yalchin, Ann-Marie Baker, Trevor A. Graham, Ailsa Hart
Summary: Patients with colonic inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC), and are enrolled into a surveillance programme aimed at detecting dysplasia or early cancer. Current surveillance programmes are guided by clinical, endoscopic or histological predictors of colitis-associated CRC (CA-CRC). There has been significant progress in understanding predictors of disease progression and improvements in endoscopic technique and management, leading to a decrease in the incidence of CA-CRC over the past 50 years. However, there is still room for improvement in our molecular understanding of CA-CRC progression and better risk stratification for patients with IBD.
Review
Oncology
Lucia Cerrito, Maria Elena Ainora, Carolina Mosoni, Raffaele Borriello, Antonio Gasbarrini, Maria Assunta Zocco
Summary: Hepatocellular carcinoma (HCC) is a common malignancy and a leading cause of tumor-related death. While imaging biomarkers are widely used in HCC diagnosis and treatment monitoring, molecular biomarkers have limited roles. However, molecular biomarkers may play an important role in prognosis estimation and treatment monitoring.
Article
Chemistry, Multidisciplinary
Lili Teng, Xiaoyu Han, Yongchao Liu, Chang Lu, Baoli Yin, Shuangyan Huan, Xia Yin, Xiao-Bing Zhang, Guosheng Song
Summary: A novel nanozyme with oxidase-like activity was developed for acid-induced cancer therapy, utilizing ratiometric near-infrared fluorescence-photoacoustic molecular imaging to report its catalytic activity. The nanozyme showed excellent anticancer efficacy in the tumor microenvironment, and the ratiometric signals provided a new approach for predicting its efficacy in living systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Psychiatry
Chang Qi, Xiaobing Fan, Sean Foxley, Qiuxia Wu, Jinsong Tang, Wei Hao, An Xie, Jianbin Liu, Zhijuan Feng, Tieqiao Liu, Yanhui Liao
Summary: This study found that abnormalities in the insula cortex (IC) gray matter volume (GMV) can detect craving state and predict relapse susceptibility among methamphetamine (MA) users. The IC GMV had a positive correlation with craving scores and showed good discrimination between subjects with and without craving. Using optimal cut-off values, MRI may serve as a biomarker for diagnosing craving state and objectively measuring craving in MA users.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Oncology
Pardeep Kumar, Sushil Kumar Tripathi, Chang-Po Chen, Neil Mehta, Bishnuhari Paudyal, Eric Wickstrom, Mathew L. Thakur
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2016)
Article
Urology & Nephrology
Sushil Tripathi, Edouard J. Trabulsi, Leonard Gomella, Sung Kim, Peter McCue, Charles Intenzo, Ruth Birbe, Ashish Gandhe, Pardeep Kumar, Mathew Thakur
Article
Radiology, Nuclear Medicine & Medical Imaging
Sushil K. Tripathi, Pardeep Kumar, Edouard J. Trabulsi, Sung Kim, Peter A. McCue, Charles Intenzo, Adam Berger, Leonard Gomella, Mathew L. Thakur
NUCLEAR MEDICINE AND BIOLOGY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pardeep Kumar, Sushil K. Tripathi, C. P. Chen, Eric Wickstrom, Mathew L. Thakur
MOLECULAR IMAGING AND BIOLOGY
(2019)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ebru Salmanoglu, Sung Kim, Mathew L. Thakur
SEMINARS IN NUCLEAR MEDICINE
(2018)
Article
Urology & Nephrology
Hong Truong, Leonard G. Gomella, Mathew L. Thakur, Edouard J. Trabulsi
WORLD JOURNAL OF UROLOGY
(2018)
Review
Oncology
Nicholas G. Zaorsky, Kosj Yamoah, Madhukar L. Thakur, Edouard J. Trabulsi, Timothy N. Showalter, Mark D. Hurwitz, Adam P. Dicker, Robert B. Den
Article
Biochemistry & Molecular Biology
Shiv Ram Krishn, Amrita Singh, Nicholas Bowler, Alexander N. Duffy, Andrea Friedman, Carmine Fedele, Senem Kurtoglu, Sushi K. Tripathi, Kerith Wang, Adam Hawkins, Aejaz Sayeed, Chirayu P. Goswami, Madhukar L. Thakur, Renato V. Iozzo, Stephen C. Peiper, William K. Kelly, Lucia R. Languino
Article
Medicine, Research & Experimental
Junning Yang, Claire Simonneau, Robert Kilker, Laura Oakley, Matthew D. Byrne, Zuzana Nichtova, Ioana Stefanescu, Fnu Pardeep-Kumar, Sushil Tripathi, Eric Londin, Pascale Saugier-Veber, Belinda Willard, Mathew Thakur, Stephen Pickup, Hiroshi Ishikawa, Horst Schroten, Richard Smeyne, Arie Horowitz
EMBO MOLECULAR MEDICINE
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sushil K. Tripathi, Rhonda Kean, Emily Bongiorno, Douglas C. Hooper, Yuan-Yuan Jin, Eric Wickstrom, Peter A. McCue, Mathew L. Thakur
MOLECULAR IMAGING AND BIOLOGY
(2020)
Article
Endocrinology & Metabolism
Gabriella Eisler, Jasmin R. Kastner, Marc C. Torjman, Abdurizzagh Khalf, David Diaz, Alek R. Dinesen, Channy Loeum, Mathew L. Thakur, Paul Strasma, Jeffrey I. Joseph
BMJ OPEN DIABETES RESEARCH & CARE
(2019)
Review
Biochemistry & Molecular Biology
Anupriya Chhabra, Mathew L. Thakur
Summary: This article discusses the potential of theragnostic radionuclide pairs for the management of prostate cancer, with a special emphasis on the emerging theragnostic radionuclide pair, Copper-64/Copper-67 (Cu-64/Cu-67).
Review
Radiology, Nuclear Medicine & Medical Imaging
Ebru Salmanoglu, Kimberly Klinger, Chandni Bhimani, Alexander Sevrukov, Mathew L. Thakur
CLINICAL AND TRANSLATIONAL IMAGING
(2019)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ebru Salmanoglu, Ethan Halpern, Eduoard J. Trabulsi, Sung Kim, Mathew L. Thakur
CLINICAL AND TRANSLATIONAL IMAGING
(2018)
Article
Urology & Nephrology
Edouard J. Trabulsi, Sushil K. Tripathi, Leonard Gomella, Charalambos Solomides, Eric Wickstrom, Mathew L. Thakur