Article
Urology & Nephrology
Irene Capelli, Fabio Pizza, Marco Ruggeri, Lorenzo Gasperoni, Elisa Carretta, Gabriele Donati, Giuseppe Cianciolo, Giuseppe Plazzi, Gaetano La Manna
Summary: The study investigated the prevalence, progression, risk factors, and impact of uraemic RLS on dialysis patients, finding associations with older age, diabetes, low albumin, and low body mass index. Results showed that RLS in dialysis patients was linked to reduced survival and had negative impacts on quality of life. Kidney transplantation could be an effective treatment option for RLS in HD patients, highlighting the secondary nature of RLS in this population.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Szymon Suwala, Jakub Rzeszuto, Rafal Glonek, Magdalena Krintus, Roman Junik
Summary: The study aims to compare the prevalence of restless legs syndrome (RLS) in patients with thyroid gland diseases and individuals with a healthy thyroid gland. The results show that RLS is more common in patients with thyroid disease, particularly in those with Hashimoto's disease.
Review
Clinical Neurology
C. Trenkwalder, M. Tinelli, G. K. Sakkas, Y. Dauvilliers, R. Ferri, R. Rijsman, W. Oertel, J. Jaarsma
Summary: Restless legs syndrome (RLS) imposes significant personal and social burden, while achieving adequate diagnosis and treatment of RLS can bring substantial economic savings.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Ferhat Balgetir, Murat Gonen, Ayse Berilgen, Emrah Aytac, Caner Feyzi Demir, Bulent Mungen
Summary: A retrospective study of 460 patients diagnosed with RLS at Firat University Medical School revealed a new variant of the disease affecting the head region, with most cases also involving the arms. Treatment with dopaminergic therapy alleviated symptoms in all patients, suggesting that this variant could be labeled as restless head syndrome.
NEUROLOGICAL SCIENCES
(2022)
Article
Health Care Sciences & Services
Stefania Diaconu, Laura Irincu, Larisa Ungureanu, Bogdan Ciopleias, Diana Tint, Cristian Falup-Pecurariu
Summary: In this cross-sectional study of 131 Parkinson's disease patients, 26.71% met the diagnostic criteria for restless legs syndrome (RLS). RLS was associated with poorer sleep quality and significant correlations were found between RLS and certain types of pain (especially nocturnal pain), physical fatigue, and probable sleep-disordered breathing.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Yanhong Guo, Yuan Sang, Tian Pu, Xiaodan Li, Yulin Wang, Lu Yu, Yan Liang, Liuwei Wang, Peipei Liu, Lin Tang
Summary: This study revealed a significant association between serum hepcidin levels and RLS in patients undergoing PD. Independent determinant factors of RLS in PD patients included PD duration, hemoglobin level, calcium level, albumin level, hepcidin level, and residual kidney function. These findings suggest a potential link between serum hepcidin and RLS in PD patients.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Nan Huo, Carin Y. Smith, Liliana Gazzuola Rocca, Walter A. Rocca, Michelle M. Mielke
Summary: This cohort study found that the risk of restless legs syndrome was increased among women who underwent bilateral oophorectomy prior to menopause, especially those without a benign ovarian indication.
Review
Urology & Nephrology
Mitchell H. Rosner, Faeq Husain-Syed, Thiago Reis, Claudio Ronco, Raymond Vanholder
Summary: Uremic encephalopathy is a central nervous system abnormality associated with kidney dysfunction, difficult to diagnose with no defining features. Treatment should consider kidney replacement therapy based on individual clinical context.
KIDNEY INTERNATIONAL
(2022)
Article
Clinical Neurology
Nada Ahmed, Mohamed Kandil, Mohamed Elfil, Abdalla Jamal, Brian B. Koo
Summary: Restless legs syndrome (RLS) is more prevalent in individuals with hypothyroidism, and hypothyroidism is more common in individuals with RLS. There is a significant association between RLS and thyroid disease, which may shed light on the complex biological mechanisms underlying RLS.
JOURNAL OF SLEEP RESEARCH
(2021)
Review
Clinical Neurology
Mingyang Tang, Qingqing Sun, Yanan Zhang, Huimin Li, Dong Wang, Ying Wang, Zan Wang
Summary: Restless legs syndrome (RLS) is a sensorimotor disorder with a distinct circadian rhythm, and this review explores the possible causes for the fluctuation of symptoms, including levels of iron, dopamine, melatonin, melanocortin, and thyroid-stimulating hormone in the brain, as well as conditions such as peripheral hypoxia and microvascular function disorders. Metabolic disturbances of these substances can create a pathological imbalance, which is further exacerbated by physiological fluctuations of circadian rhythms, leading to the worsening of RLS symptoms at night. The review concludes with suggestions for RLS treatment and future research directions.
FRONTIERS IN NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Bo Yang, Hongqing Yin, Jianwei Wang, Jiali Gan, Jingfang Li, Rui Han, Ming Pei, Lili Song, Hongtao Yang
Summary: This study uses metabolomics analysis to identify potential biomarkers for PD-RLS and validates their diagnostic and predictive abilities through ROC analysis. The findings provide a theoretical basis for the early diagnosis, prevention, and treatment of PD-RLS.
Review
Neurosciences
Qing Lv, Xinlin Wang, Tetsuya Asakawa, Xiao Ping Wang
Summary: Restless legs syndrome is a neurological disorder characterized by a strong desire to move when at rest and paraesthesia in the lower legs. Current first-line treatment includes dopaminergic drugs but long-term use may lead to augmentation, prompting exploration of alternative therapies. The pathogenesis of RLS is not well understood and likely involves complex neural pathways with multiple genetic factors contributing to the disease.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Ayham Alhusseini, Suaad Hamsho, Hadi Alabdullah, Mohammed Alaswad, Mouhammed Sleiay, Omar Alsamarrai
Summary: This case describes a male patient with renal failure presenting with uremic encephalopathy and the lentiform fork sign on brain MRI. After dialysis treatment, the patient's condition greatly improved.
CLINICAL CASE REPORTS
(2023)
Review
Neurosciences
Christopher J. Earley, Byron C. Jones, Sergi Ferre
Summary: This article discusses the two main pathological elements of Restless Legs Syndrome (RLS): brain iron deficiency (BID) and altered dopaminergic system. Through research on diet-induced BID rodent models, it is possible to gain a better understanding of the effects of brain iron deficiency on the dopaminergic pathway and other potential pathways.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Critical Care Medicine
John W. Winkelman
Summary: Restless legs syndrome is a neurological disorder that affects 2%-3% of adults, mainly impacting sleep and quality of life, but can be managed with medication. Treatment involves addressing factors that worsen the disease, such as iron deficiency, and adjusting medication use. However, some patients do not respond well to initial treatment, and certain medications often result in disease exacerbation.