期刊
SEMINARS IN LIVER DISEASE
卷 33, 期 2, 页码 97-102出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0033-1345716
关键词
hepatitis B virus; genotype; viral load; HBsAg level; hepatocellular carcinoma; cirrhosis
资金
- National Taiwan University, the Department of Health
- National Science Council, Executive Yuan, Taiwan
- Taiwan LiverNet Consortium (National Research Program for Biopharmaceuticals, National Science Council) [100-2325-B-002-052, 101-2325-B-002-073]
Clinical outcomes of chronic hepatitis B virus (HBV) infection vary widely. In addition to host factors, several viral factors including HBV genotype, viral load, specific viral mutations and quantitative HBsAg levels, have been associated with disease outcomes. Among viral factors, HBV genotype correlates with not only the clinical outcomes, but also with the response to interferon treatment. Currently, 10 HBV genotypes have been identified. Compared with genotype A and B cases, patients with genotypes C and D have lower rates and usually delayed onset of spontaneous HBeAg seroconversion. HBV-genotype C has a higher frequency of basal core promoter (BCP) A1762T/G1764A mutation and preS deletion, and a higher viral load than genotype B. Similarly, genotype D has a higher prevalence of BCPA1762T/G1764A mutation than genotype A. These observations suggest pathogenic differences between HBV genotypes. Genotyping of HBV can help practicing physicians identify chronic hepatitis B patients at risk of disease progression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据