Review
Clinical Neurology
Yang Ji, Yingmin Liang, Judith C. W. Mak, Mary S. M. Ip
Summary: Obesity is a strong risk factor for both obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD). Intermittent hypoxia plays an important role in the development of NAFLD in OSA. Understanding the roles of obesity and intermittent hypoxia in NAFLD is crucial for gaining more knowledge about the health consequences of OSA and devising effective therapeutic strategies.
Article
Biochemistry & Molecular Biology
Tehila Dahan, Shahd Nassar, Olga Yajuk, Eliana Steinberg, Ofra Benny, Nathalie Abudi, Inbar Plaschkes, Hadar Benyamini, David Gozal, Rinat Abramovitch, Alex Gileles-Hillel
Summary: Obstructive sleep apnea (OSA) is a common disease associated with dyslipidemia, insulin resistance, and metabolic syndrome. Brown adipose tissue (BAT) is believed to affect systemic glucose tolerance through adaptive thermogenesis, while chronic hypoxia affects the function and metabolism of BAT. This study shows that chronic hypoxia leads to browning of BAT, but also tissue-specific and systemic insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bilgehan Ozcan, Britanny Blachot-Minassian, Stephanie Paradis, Lucile Maziere, Marie Chambion-Diaz, Sophie Bouyon, Jean-Louis Pepin, Vincent Pialoux, Claire Arnaud, Christophe Moinard, Elise Belaidi
Summary: Intermittent hypoxia, a hallmark of obstructive sleep apnea, triggers oxidative stress and contributes to cardiovascular consequences. Citrulline supplementation has shown protective effects on the cardiovascular system. This study demonstrates that citrulline significantly reduces blood pressure and infarct size under intermittent hypoxia, indicating its potential as a pharmacological strategy for high-risk OSA patients.
Article
Biochemistry & Molecular Biology
Yunfei Luo, Qiongfeng Chen, Junrong Zou, Jingjing Fan, Yuanjun Li, Zhijun Luo
Summary: This study explored the effects of hypoxia as a noninvasive and tolerable alternative treatment for obesity and nonalcoholic fatty liver disease (NAFLD). The results showed that hypoxia could alleviate bodyweight gain and insulin resistance induced by a high-fat diet, reverse enlargement of adipocytes and fatty liver, and protect liver function. Hypoxia also activated the energy sensing enzyme AMPK and increased serum levels of epinephrine, suggesting its potential therapeutic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Li-Da Chen, Zhi-Wei Huang, Yu-Zhen Huang, Jie-Feng Huang, Zhong-Ping Zhang, Xue-Jun Lin
Summary: The study explores the hepatic metabolomic profile in a chronic intermittent hypoxia mouse model and identifies altered metabolites and related metabolic pathways. Chronic intermittent hypoxia treatment leads to liver injury in mice, with alterations in amino acid metabolism, lipid metabolism, carbohydrate metabolism, and ferroptosis pathway. Understanding these mechanisms can help in identifying potential therapeutic targets for the link between obstructive sleep apnea and liver injury.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Charlotte Breuillard, Sophie Moulin, Sophie Bouyon, Morgane Couchet, Christophe Moinard, Elise Belaidi
Summary: Obstructive sleep apnea syndrome (OSAS) is associated with chronic intermittent hypoxia (cIH) that causes slight impairment of nutritional status and immunity.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Fan Wang, Juanjuan Zou, Huajun Xu, Weijun Huang, Xiaoman Zhang, Zhicheng Wei, Xinyi Li, Yupu Liu, Jianyin Zou, Feng Liu, Huaming Zhu, Hongliang Yi, Jian Guan, Shankai Yin
Summary: Chronic intermittent hypoxia and chronic sleep fragmentation are two main pathological features of obstructive sleep apnea. This study found correlations between intestinal microbiota, metabolites, and lipid metabolism under conditions of CIH or CSF, which affected adipose tissue and hepatic lipid metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Xuehao Qiu, Lingling Li, Jiayun Wei, Xueqian An, Janet Akoto Ampadu, Weikun Zheng, Chenyi Yu, Chenlei Peng, Xiucui Li, Xiaohong Cai
Summary: The study aimed to investigate the mechanism of Nrf2 protecting neural cells from endoplasmic reticulum stress induced by chronic intermittent hypoxia and sleep fragmentation, which are associated with cognitive impairment in OSAHS. The results demonstrated that chronic intermittent hypoxia and sleep fragmentation aggravated cognitive impairment in mice, while activation of Nrf2 alleviated the impairment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Jonathan Gaucher, Guillaume Vial, Emilie Montellier, Maelle Guellerin, Sophie Bouyon, Emeline Lemarie, Veronique Pelloux, Anne Bertrand, Karin Pernet-Gallay, Frederic Lamarche, Anne-Laure Borel, Claire Arnaud, Elise Belaidi, Karine Clement, Diane Godin Ribuot, Judith Aron-Wisnewsky, Jean-Louis Pepin
Summary: Sleep Apnea Syndrome (SAS), a common chronic disease affecting nearly one billion people worldwide, has been found to be an independent risk factor for the development and progression of non-alcoholic fatty liver disease (NAFLD) through the occurrence of intermittent hypoxia (IH). This study revealed that IH reprograms gene expression and increases the oxidative capacity of liver mitochondria, leading to an imbalance between oxidative stress and antioxidant defense, which in turn contributes to the development of liver disease. These findings provide insights into the mechanisms underlying NAFLD development during SAS and suggest potential therapeutic targets and biomarkers.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Elena Diaz-Garcia, Sara Garcia-Tovar, Raquel Casitas, Ana Jaureguizar, Ester Zamarron, Begona Sanchez-Sanchez, Ana Sastre-Perona, Eduardo Lopez-Collazo, Francisco Garcia-Rio, Carolina Cubillos-Zapata
Summary: The study shows that patients with obstructive sleep apnea (OSA) exhibit elevated levels of PSPC1, which is cleaved from monocytes by MMP2 and released into the plasma. Intermittent hypoxia (IH) promotes the expression of PSPC1, TGF beta, and MMP2 in monocytes, leading to increased expression of genes driving epithelial-to-mesenchymal transition. These findings suggest a mechanism by which hypoxemia contributes to tumor progression and aggressiveness in OSA patients.
Review
Medicine, General & Internal
Lorenz M. W. Holzner, Andrew J. Murray
Summary: NAFLD and NASH are major public health concerns with limited treatment options. Studies show that HIF plays important roles in modulating these diseases, potentially aiding in the development of new therapeutic strategies.
FRONTIERS IN MEDICINE
(2021)
Article
Physiology
Ming Deng, Yi-teng Huang, Jian-qing Xu, Xiao Ke, Yi-fei Dong, Xiao-shu Cheng
Summary: The study found that patients with severe OSAHS were more likely to have hypertension and higher LV mass and LV mass index. The association between intermittent hypoxia and left ventricular remodeling was significant, with oxygen desaturation index (ODI) being the most relevant parameter to LV remodeling among various intermittent hypoxia parameters.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Li-Pang Chuang, Huang-Pin Wu, Li-Ang Lee, Li-Chung Chiu, Shih-Wei Lin, Han-Chung Hu, Kuo-Chin Kao, Ning-Hung Chen, Jung-Wei Tsai, Jong-Hwei Su Pang
Summary: This study found that under intermittent hypoxia conditions, the expression of IL-8 was enhanced in monocytes of adult OSA patients, leading to an increase in the migration ability of monocytes towards IL-8.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Huojun Zhang, Ling Zhou, Yuhao Zhou, Lingling Wang, Weiling Jiang, Lu Liu, Shuang Yue, Pengdou Zheng, Huiguo Liu
Summary: In this study, we found that IH aggravates NAFLD via RIPK3-dependent necroptosis-modulated Nrf2/NF Kappa B signaling pathway. RIPK3 downregulation significantly reduced hepatocyte necroptosis, and ameliorated oxidative stress and inflammation through modulating Nrf2/NF Kappa B pathway in vitro and in vivo. Additionally, pretreatment with TBHQ effectively blocked the generation of oxidative productions and inflammatory cytokines.
Article
Cardiac & Cardiovascular Systems
Ziyan Wang, Yiming Zeng, Huihuang Lin
Summary: The study found that rat offspring born under conditions of chronic intermittent hypoxia in utero may develop systemic inflammation and be susceptible to artery injury, leading to intima thickening and pre-atherosclerotic lesions. Additionally, intrauterine and extrauterine CIH had interactions regarding the expression of biomarkers and intima thickness.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Melania Gaggini, Fabrizia Carli, Chiara Rosso, Emma Buzzigoli, Milena Marietti, Veronica Della Latta, Demetrio Ciociaro, Maria Lorena Abate, Roberto Gambino, Maurizio Cassader, Elisabetta Bugianesi, Amalia Gastaldelli
Article
Endocrinology & Metabolism
L. De Carli, R. Gambino, C. Lubrano, R. Rosato, D. Bongiovanni, F. Lanfranco, F. Broglio, E. Ghigo, S. Bo
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2018)
Article
Endocrinology & Metabolism
Simona Bo, Gabriele Togliatto, Roberto Gambino, Valentina Ponzo, Giusy Lombardo, Rosalba Rosato, Maurizio Cassader, Maria Felice Brizzi
ACTA DIABETOLOGICA
(2018)
Letter
Endocrinology & Metabolism
V. Ponzo, L. Gentile, R. Gambino, R. Rosato, I. Cioffi, N. Pellegrini, A. Benso, F. Broglio, M. Cassader, S. Bo
DIABETES & METABOLISM
(2018)
Review
Gastroenterology & Hepatology
Giovanni Musso, Maurizio Cassader, Elena Paschetta, Roberto Gambino
Letter
Gastroenterology & Hepatology
Giovanni Musso, Roberto Gambino
Article
Pharmacology & Pharmacy
F. Barutta, S. Bellini, R. Mastrocola, R. Gambino, F. Piscitelli, V. di Marzo, B. Corbetta, V. K. Vemuri, A. Makriyannis, L. Annaratone, G. Bruno, G. Gruden
BRITISH JOURNAL OF PHARMACOLOGY
(2018)
Article
Gastroenterology & Hepatology
Giovanni Musso, Francesca Saba, Maurizio Cassader, Elena Paschetta, Franco De Michieli, Silvia Pinach, Luciana Framarin, Mara Berrutti, Nicola Leone, Renato Parente, Mohammad Taghi Ayoubi Khajekini, Adriana Zarovska, Roberto Gambino
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Endocrinology & Metabolism
Roberto Gambino, Giovanni Fanni, Gabriele Togliatto, Valentina Ponzo, Ilaria Goitre, Maurizio Cassader, Maria Felice Brizzi, Simona Bo
ACTA DIABETOLOGICA
(2019)
Article
Medicine, General & Internal
Giovanni Musso, Roberto Gambino, Maurizio Cassader, Elena Paschetta
BMJ-BRITISH MEDICAL JOURNAL
(2019)
Article
Multidisciplinary Sciences
Valentina Ponzo, Ilario Ferrocino, Adriana Zarovska, Maria Bernadette Amenta, Filomena Leone, Clara Monzeglio, Rosalba Rosato, Marianna Pellegrini, Roberto Gambino, Maurizio Cassader, Ezio Ghigo, Luca Cocolin, Simona Bo
Article
Endocrinology & Metabolism
Iolanda Cioffi, Roberto Gambino, Rosalba Rosato, Bice Properzi, Giuseppe Regaldo, Valentina Ponzo, Marianna Pellegrini, Franco Contaldo, Fabrizio Pasanisi, Ezio Ghigo, Simona Bo
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2020)
Article
Medicine, General & Internal
Giovanni Musso, Antonio Sircana, Francesca Saba, Maurizio Cassader, Roberto Gambino
Article
Urology & Nephrology
Federica Barutta, Shunsuke Kimura, Koji Hase, Stefania Bellini, Beatrice Corbetta, Alessandro Corbelli, Fabio Fiordaliso, Antonella Barreca, Mauro Giulio Papotti, Gian Marco Ghiggeri, Gennaro Salvidio, Dario Roccatello, Valentina Audrito, Silvia Deaglio, Roberto Gambino, Stefania Bruno, Giovanni Camussi, Miriam Martini, Emilio Hirsch, Marilena Durazzo, Hiroshi Ohno, Gabriella Gruden
Summary: The study found that the M-Sec?TNT system plays an important protective role in podocytes by rescuing them via mitochondrial horizontal transfer. Overexpression of M-Sec in FSGS suggests a cytoprotective role, while M-Sec deletion leads to progressive FSGS development. These findings provide insight into potential therapeutic targets for FSGS and suggest regenerative cell-based therapy options through TNT-mediated organelle transfer.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Food Science & Technology
Andrea Devecchi, Sonia Demasi, Francesca Saba, Rosalba Rosato, Roberto Gambino, Valentina Ponzo, Antonella De Francesco, Paola Massarenti, Simona Bo, Valentina Scariot
Summary: This explorative study found that adding phenolics from edible roses to meals increased urinary phenolic excretion in healthy volunteers, suggesting potential antioxidant effects of edible flowers. Additional larger trials are needed to confirm these findings.
POLISH JOURNAL OF FOOD AND NUTRITION SCIENCES
(2021)