Article
Multidisciplinary Sciences
Deanna M. Santer, Daniel Li, Yanal Ghosheh, Muhammad Atif Zahoor, Dhanvi Prajapati, Bettina E. Hansen, D. Lorne J. Tyrrell, Jordan J. Feld, Adam J. Gehring
Summary: Interferon-lambda is a treatment option for early COVID-19 that enhances innate immunity and accelerates viral clearance without dampening peripheral adaptive immunity. T cell responses are delayed in older adults, but interferon-lambda can overcome this delay.
NATURE COMMUNICATIONS
(2022)
Article
Virology
Keyla Santos Guedes de Sa, Ednelza da Silva Graca Amoras, Simone Regina Souza da Silva Conde, Maria Alice Freitas Queiroz, Izaura Maria Vieira Cayres-Vallinoto, Ricardo Ishak, Antonio Carlos Rosario Vallinoto
Summary: Inefficient immune response and viral evasion mechanisms contribute to the chronicity of hepatitis C virus infection. The gene expressions of TLR3 and IFN-lambda 3 in liver tissue were investigated as potential biomarkers of HCV infection. The study found that TLR3 expression was higher and IFNL3 expression was lower in chronic HCV carriers, with different levels of expression in early and advanced stages of liver fibrosis and inflammation, showing no correlation with serum viral load.
Review
Genetics & Heredity
Michelle Mohlenberg, Thomas R. O'Brien, Rune Hartmann
Summary: The genetic variation within the interferon lambda locus has a significant impact on the treatment and clearance of hepatitis C virus (HCV). This review summarizes the genetic data of IFNL3/IFNL4 loci and discusses the causality. It also explores the relationship between genetic variation at the IFNL4 loci and HCV virus evolution, as well as the influence of the IFNL4 gene on liver inflammation and fibrosis.
GENES AND IMMUNITY
(2022)
Article
Biotechnology & Applied Microbiology
Connor G. G. Bamford, John McLauchlan
Summary: The host IFNL4 haplotype status influences the development of chronic HCV infection. Specific amino acid variants at multiple sites on the HCV polyprotein correlate with functional SNPs in the IFNL4 locus, which may affect virus replication and infection outcome. Each individual IFNL4-associated variant has a nuanced effect on viral replication, potentially mediating resistance to IFN lambda 4 effects.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Veterinary Sciences
Hao An, Yumei Liu, Ming Shu, Junhao Chen
Summary: We report that interleukin-22 (IL-22) activates the phosphorylation of STAT3 to enhance the expression of TRIM25 induced by interferon-gamma (IFN-γ) and provides a defense against duck viral hepatitis A virus type 1 (DHAV-1) by inducing the production of IFNs.
VETERINARY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Qian Chen, Mairene Coto-Llerena, Aleksei Suslov, Raphael Dias Teixeira, Isabel Fofana, Sandro Nuciforo, Maike Hofmann, Robert Thimme, Nina Hensel, Volker Lohmann, Charlotte K. Y. Ng, George Rosenberger, Stefan Wieland, Markus H. Heim
Summary: The genetic variant in the IFN-lambda 4 gene is associated with a poor prognosis of hepatitis C virus infection. The IFN-lambda 4 protein induces ER stress, inhibiting the presentation of HCV epitopes to CD8(+) T cells.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Mehran Shokri, Oreinab Ghaffari Khonakdar, Mousa Mohammadnia-Afrouzi, Mahmoud Sadeghi-Haddad-Zavareh, Amirhossein Hasanpour, Mohammad Barary, Soheil Ebrahimpour
Summary: The study found that IL-29 and IL-28A levels were significantly higher in acute brucellosis patients before treatment compared to after treatment. The levels of IL-29 and IL-28A may serve as valuable biomarkers for follow-up in brucellosis patients.
MEDIATORS OF INFLAMMATION
(2021)
Article
Immunology
G. Cakmak Genc, S. Karakas Celik, A. Kocaaga, R. Koca, A. Dursun
Summary: The study did not find a direct relationship between IL-28 and IL-29 gene polymorphisms and Behcet's disease susceptibility. However, certain genotypes of the IL28 gene were found to be associated with central nervous system involvement in BD patients. Further investigation is needed to explore the role of IL-28 and IL-29 in Behcet's disease.
IMMUNOLOGICAL INVESTIGATIONS
(2021)
Article
Immunology
Priyanka Talukdar, Beth F. Junecko, Daniel S. Lane, Pauline Maiello, Joshua T. Mattila
Summary: IFN-λ is expressed in granulomas and may influence myeloid cell function and immunity in tuberculosis. The expression of IFN-λ varies in different granuloma microenvironments, primarily expressed by macrophages and neutrophils, with differences in subcellular localization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Mairene Coto-Llerena, Marco Lepore, Julian Spagnuolo, Daniela Di Blasi, Diego Calabrese, Aleksei Suslov, Glenn Bantug, Francois Ht Duong, Luigi M. Terracciano, Gennaro De Libero, Markus H. Heim
Summary: IFNλ plays a crucial role in innate pathogen defense in the lung and intestine, with IFNλ4 inhibiting spontaneous clearance of HCV and affecting T-cell responses. However, the mechanism by which IFNλ4 promotes CD8(+) T-cell responses and inhibits host immunity to HCV infections remains unclear.
LIFE SCIENCE ALLIANCE
(2021)
Article
Biochemistry & Molecular Biology
Debpali Sur, Katerina Leonova, Bar Levi, Shany Ivon Markowitz, Raichel Cohen-Harazi, Ilya Gitlin, Katerina Gurova, Andrei Gudkov, Albert Pinhasov, Igor Koman, Elimelech Nesher
Summary: Interferon signaling in inflammation releases cytokines and chemokines to combat viral, bacterial, and cancerous invasions. However, prolonged exposure to interferons leads to immune exhaustion, enhancing inflammation and disease promotion. A peptide called ALOS4 has shown anti-inflammatory properties by upregulating interferon-response genes, supporting antiviral response without inhibiting interferon signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Azusa Ohta, Eiichi Ogawa, Masayuki Murata, Yuji Matsumoto, Sho Yamasaki, Hiroaki Ikezaki, Norihiro Furusyo
Summary: The study aimed to assess the association between host genetic factors and de novo HCC after achieving sustained virological response (SVR) in CHC patients. The PNPLA3 genotype was independently associated with the development of de novo HCC in CHC patients who achieved SVR.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ara Jo, Jina Won, Chan Hee Gil, Su Keun Kim, Kang-Mu Lee, Sang Sun Yoon, Hyun Jik Kim
Summary: Our recent study reveals the mechanism in which human nasal commensal Staphylococcus epidermidis enhances antiviral immune response in the nasal mucosa. The bacterium promotes a balance of protease-protease inhibitor, preventing influenza virus replication in the nasal mucosa and lungs. This manipulation of cellular environment through Serpine1 induction by S. epidermidis disturbs the spread of the virus to the lungs.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Gastroenterology & Hepatology
Machiko Umemura, Koji Ogawa, Kenichi Morikawa, Akinori Kubo, Yoshimasa Tokuchi, Ren Yamada, Takashi Kitagataya, Taku Shigesawa, Tomoe Shimazaki, Megumi Kimura, Kazuharu Suzuki, Akihisa Nakamura, Masatsugu Ohara, Naoki Kawagishi, Takaaki Izumi, Masato Nakai, Takuya Sho, Goki Suda, Mitsuteru Natsuizaka, Kota Ono, Kazumoto Murata, Masaya Sugiyama, Masashi Mizokami, Naoya Sakamoto
Summary: This study investigated the effects of nucleos(t)ide analogs (NAs) on hepatitis B surface antigen (HBsAg) reduction and interferon-lambda3 (IFN-lambda 3) induction in chronic hepatitis B (CHB) patients. The results showed that nucleotide analog (ADV/TDF) treatment reduced HBsAg levels greater compared with nucleoside analog (ETV) in parallel with IFN-lambda 3 induction.
HEPATOLOGY RESEARCH
(2022)
Article
Microbiology
Rebecca L. Casazza, Drake T. Philip, Helen M. Lazear
Summary: IFN-lambda has antiviral effects during pregnancy, but its effects depend on the gestational stage. Infection with ZIKV earlier in pregnancy enhances transplacental transmission. IFN-lambda signaling in maternal tissues causes fetal resorption and intrauterine growth restriction in dams with robust ZIKV infection. Maternal IFN-lambda signaling also contributes to pregnancy pathology induced by poly(I.C) treatment.
Article
Gastroenterology & Hepatology
Cynthia Brisac, Shadi Salloum, Victor Yang, Esperance A. K. Schaefer, Jacinta A. Holmes, Stephane Chevaliez, Jian Hong, Charlie Carlton-Smith, Nadia Alatrakchi, Annie Kruger, Wenyu Lin, Raymond T. Chung
JOURNAL OF HEPATOLOGY
(2016)
Article
Gastroenterology & Hepatology
Esperance A. K. Schaefer, James Meixiong, Christina Mark, Amy Deik, Daniel L. Motola, Dahlene Fusco, Andrew Yang, Cynthia Brisac, Shadi Salloum, Wenyu Lin, Clary B. Clish, Lee F. Peng, Raymond T. Chung
WORLD JOURNAL OF GASTROENTEROLOGY
(2016)
Article
Medicine, General & Internal
Kristian R. Olson, Amir H. Davarpanah, Esperance A. Schaefer, Nahel Elias, Joseph Misdraji
NEW ENGLAND JOURNAL OF MEDICINE
(2017)
Article
Immunology
Anna Lidofsky, Jacinta A. Holmes, Eoin R. Feeney, Annie J. Kruger, Shadi Salloum, Hui Zheng, Isabel S. Seguin, Akif Altinbas, Ricard Masia, Kathleen E. Corey, Jenna L. Gustafson, Esperance A. Schaefer, Peter W. Hunt, Steven Deeks, Ma Somsouk, Kara W. Chew, Raymond T. Chung, Nadia Alatrakchi
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Virology
Xiaoqiong Duan, Shilin Li, Jacinta A. Holmes, Zeng Tu, Yujia Li, Dachuan Cai, Xiao Liu, Wenting Li, Chunhui Yang, Baihai Jiao, Esperance A. Schaefer, Dahlene N. Fusco, Shadi Salloum, Limin Chen, Wenyu Lin, Raymond T. Chung
JOURNAL OF VIROLOGY
(2018)
Article
Cell & Tissue Engineering
Qiurong Ding, Youn-Kyoung Lee, Esperance A. K. Schaefer, Derek T. Peters, Adrian Veres, Kevin Kim, Nicolas Kuperwasser, Daniel L. Motola, Torsten B. Meissner, William T. Hendriks, Marta Trevisan, Rajat M. Gupta, Annie Moisan, Eric Banks, Max Friesen, Robert T. Schinzel, Fang Xia, Alexander Tang, Yulei Xia, Emmanuel Figueroa, Amy Wann, Tim Ahfeldt, Laurence Daheron, Feng Zhang, Lee L. Rubin, Lee F. Peng, Raymond T. Chung, Kiran Musunuru, Chad A. Cowan
Review
Rheumatology
Esperance A. K. Schaefer, Daniel S. Pratt
CURRENT OPINION IN RHEUMATOLOGY
(2012)
Review
Gastroenterology & Hepatology
Esperance A. K. Schaefer, Raymond T. Chung
Article
Gastroenterology & Hepatology
Xiao Liu, Xiaoqiong Duan, Jacinta A. Holmes, Wenting Li, Sae Hwan Lee, Zeng Tu, Chuanlong Zhu, Shadi Salloum, Anna Lidofsky, Esperance A. Schaefer, Dachuan Cai, Shilin Li, Haoju Wang, Yongfu Huang, Yongju Zhao, Ming-Lung Yu, Zhiwen Xu, Limin Chen, Jian Hong, Wenyu Lin, Raymond T. Chung
Article
Chemistry, Multidisciplinary
Mary A. Rodgers, Valerie A. Villareal, Esperance A. Schaefer, Lee F. Peng, Kathleen E. Corey, Raymond T. Chung, Priscilla L. Yang
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2012)
Review
Gastroenterology & Hepatology
Esperance A. K. Schaefer, Raymond T. Chung
SEMINARS IN LIVER DISEASE
(2013)
Article
Medicine, General & Internal
Esperance A. Schaefer, Mark A. Anderson, Arthur Y. Kim, Maroun M. Sfeir
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Article
Cell Biology
Xiaoqiong Duan, Xiao Liu, Wenting Li, Jacinta A. Holmes, Annie J. Kruger, Chunhui Yang, Yujia Li, Min Xu, Haiyan Ye, Shuang Li, Xinzhong Liao, Qiuju Sheng, Dong Chen, Tuo Shao, Zhimeng Cheng, Batul Kaj, Esperance A. Schaefer, Shilin Li, Limin Chen, Wenyu Lin, Raymond T. Chung
Article
Gastroenterology & Hepatology
Esperance Schaefer, Winona Wu, Christina Mark, Andrew Yang, Erik DiGiacomo, Charles Carlton-Smith, Shadi Salloum, Cynthia Brisac, Wenyu Lin, Kathleen E. Corey, Raymond T. Chung
HEPATOLOGY COMMUNICATIONS
(2017)
Article
Pathology
Angela R. Shih, Gregory Y. Lauwers, Anthony Mattia, Esperance A. K. Schaefer, Joseph Misdraji
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2017)