期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 35, 期 6, 页码 627-635出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-013-0397-1
关键词
AHR; EAE; FoxP3(+) Tregs; Tr1 cells; Th17 cells
资金
- National Institutes of Health [AI075285, AI093903]
- National Multiple Sclerosis Society [RG4111A1]
- Juvenile Diabetes Research Foundation [17-2011-371]
The ligand-activated transcription factor aryl hydrocarbon receptor controls the activity of several components of the immune system, many of which play an important role in neuroinflammation. This review discusses the role of AhR in T cells and dendritic cells, its relevance for the control of autoimmunity in the central nervous system, and its potential as a therapeutic target for immune-mediated disorders.
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