4.5 Review

Regulation of central nervous system autoimmunity by the aryl hydrocarbon receptor

期刊

SEMINARS IN IMMUNOPATHOLOGY
卷 35, 期 6, 页码 627-635

出版社

SPRINGER HEIDELBERG
DOI: 10.1007/s00281-013-0397-1

关键词

AHR; EAE; FoxP3(+) Tregs; Tr1 cells; Th17 cells

资金

  1. National Institutes of Health [AI075285, AI093903]
  2. National Multiple Sclerosis Society [RG4111A1]
  3. Juvenile Diabetes Research Foundation [17-2011-371]

向作者/读者索取更多资源

The ligand-activated transcription factor aryl hydrocarbon receptor controls the activity of several components of the immune system, many of which play an important role in neuroinflammation. This review discusses the role of AhR in T cells and dendritic cells, its relevance for the control of autoimmunity in the central nervous system, and its potential as a therapeutic target for immune-mediated disorders.

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