期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 36, 期 1, 页码 3-12出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-013-0405-5
关键词
AIM (apoptosis inhibitor of macrophage); Chronic inflammation; Lipolysis; IgM; Autoantibody
资金
- Global COE Research Program
- JST, CREST
Obesity is associated with various metabolic and cardiovascular diseases caused by chronic, low-grade inflammation that is initially observed in obese adipose tissue. In addition, many etiological studies in humans have shown a strong correlation between obesity and inflammatory autoimmune diseases. In this review, we focus on the involvement of apoptosis inhibitor of macrophage (AIM), a macrophage-derived blood protein, in both types of immune response. Through differential mechanisms, AIM thereby plays key roles in the pathogenesis of atherosclerosis, metabolic diseases, and obesity-associated autoimmune diseases. Thus, the regulation of blood AIM levels or AIM function has the potential to serve as a next-generation therapy against these inflammatory diseases brought about by modern lifestyle.
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