期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 32, 期 3, 页码 215-225出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-010-0210-3
关键词
Live imaging; Leukocyte migration; Chemokine; Integrin; Stromal cells
资金
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Uehara Memorial Foundation
- Sumitomo Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
During the last several years, live tissue imaging, in particular using two-photon laser microscopy, has advanced our understanding of leukocyte trafficking mechanisms. Studies using this technique are revealing distinct molecular requirements for leukocyte migration in different tissue environments. Also emerging from the studies are the ingenious infrastructures for leukocyte trafficking, which are produced by stromal cells. This review summarizes the recent imaging studies that provided novel mechanistic insights into in vivo leukocyte migration essential for immunosurveillance.
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