期刊
SEMINARS IN IMMUNOLOGY
卷 26, 期 1, 页码 80-87出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2014.01.002
关键词
IL-6 signaling; IL-6 trans-signaling; STAT3; Pancreatic cancer; Acute pancreatitis; Chronic pancreatitis
类别
资金
- Deutsche Forschungsgemeinschaft [AL 1174/3-1, AL 1174/4-1]
- Deutsche Krebshilfe [109445]
Interleukin-6 is an important pro-inflammatory cytokine strongly linked to the most burdened exocrine pancreatic diseases including acute pancreatitis, chronic pancreatitis and pancreatic cancer. However, its role in all these diseases is versatile and not completely defined. Several studies provided accumulating evidence that IL-6 is mainly involved in the JAK/STAT pathway activation promoting acute and chronic pancreatitis disease aggravation as well as pancreatic cancer initiation and progression. This review will focus on recent studies illustrating the role of IL-6 in acute and chronic pancreatitis and pancreatic oncogenesis. Further, a short overview of indicated disease pathologies will be given and the impact of IL-6 in JAK/STAT pathway, persistent STAT3 activation and cancer immunotherapy will be discussed. (C) 2014 Elsevier Ltd. All rights reserved.
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