期刊
SEMINARS IN IMMUNOLOGY
卷 24, 期 4, 页码 255-263出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2012.05.003
关键词
Activation-induced deaminase; Somatic hypermutation, Class switch recombination, Gene conversion; Antibody; B cell
类别
资金
- CIHR [MOP111132, MOP66965]
- Canada Research Chair award
Activation-induced deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) by inducing mutations and double-strand breaks at the immunoglobulin (Ig) locus in B cells. AID converts deoxycytidine (dC) to deoxyuridine (dU) in single-stranded DNA (ssDNA). This deamination reaction is enzymatically straightforward, but ultimately results in diverse biological consequences. Here, we review the enzymatic features of AID, such as the parameters that govern substrate binding and catalysis. We discuss how these properties of AID relate to secondary antibody diversification processes and the manners in which they may regulate the targeting of AID to various loci. Based on the current data on AID and other related deaminases, we propose a 3-dimensional structure for AID and how this model provides clues into AID's catalytic mechanism. (C) 2012 Elsevier Ltd. All rights reserved.
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