期刊
SEMINARS IN IMMUNOLOGY
卷 24, 期 1, 页码 43-49出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2011.11.004
关键词
Antigen-presenting cells; Dendritic cells; Microenvironment; Microbiota
类别
资金
- European Commission
- Association for International Cancer Research (AICR)
- Associazione ltaliana per la Ricerca sul Cancro (AICR)
- Fondazione Cariplo
- Italian Ministry of Health (Ricerca finalizzata)
Coordination of immune responses in the gut is a complex task. In order to fight pathogens and maintain a defined population of commensal microbes, the mucosal immune system has to coordinate information from the external (luminal) and internal (abluminal) environment and respond accordingly. Dendritic cells (DCs)are crucial cell types involved in this process as they integrate these signals and direct immunogenic or tolerogenic responses. Here, we review how various functions of DCs depend on microbial stimuli and how these stimuli influence the course of immune activation. (C) 2011 Elsevier Ltd. All rights reserved.
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