期刊
SEMINARS IN IMMUNOLOGY
卷 22, 期 3, 页码 125-131出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2010.03.003
关键词
Cancer vaccine; Tumor antigen; Self-tolerance; Transgenic mice; Clinical trial
类别
资金
- NCI NIH HHS [T32 CA082084, R01 CA056103, R01 CA168392] Funding Source: Medline
Abnormal expression of self antigens on tumors compared with normal cells provides opportunities and challenges for development of cancer vaccines. We review recent work in pre-clinical transgenic mouse models and in clinical trials that has elucidated multiple regulatory mechanisms that interfere with the induction of effective immunity. We discuss these as being either part of the normal function of the immune system or being driven by the tumor microenvironment. Collectively this work shows that it is possible to design vaccines based on tumor-associated antigens and elicit effective immunity against abnormal expression of these antigens on tumors without causing autoimmunity. (C) 2010 Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据