Article
Biology
Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek
Summary: In this study, it was identified that Tregs limit the availability of IL-2, thereby suppressing the formation of a previously uncharacterized subset of antigen-stimulated KILR CD8(+) effector T cells. These KILR CD8(+) T cells exhibit superior cell-killing abilities and can be induced by the administration of agonistic IL-2 immunocomplexes. This research has potential implications for immunotherapy targeting these cells in humans.
Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Immunology
Yihe Chen, Chunyi Shao, Nai-Wen Fan, Takeshi Nakao, Afsaneh Amouzegar, Sunil K. Chauhan, Reza Dana
Summary: In a murine model of dry eye disease (DED), a linear transition from effector to memory Th17 cells was detected during the abatement phase of acute inflammation, with persistently high levels of IL-23 and diminished levels of IL-2. Additionally, in vitro culture of effector Th17 cells with IL-23 but not IL-2 led to significant generation of memory Th17 cells. The data demonstrate a new dichotomy between IL-23 and IL-2 in driving effector Th17 cells into the memory pool in autoimmune-mediated ocular surface inflammation.
MUCOSAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pan Liu, Mingfu Liu, Deshuang Xi, Yiguang Bai, Ruixin Ma, Yaomin Mo, Gaofeng Zeng, Shaohui Zong
Summary: Spinal cord injury (SCI) causes dysfunctions in motor, sensory, and autonomic functions. The gut microbiome and short-chain fatty acids (SCFAs) play important roles in SCI. This study found that oral administration of exogenous SCFAs can promote the recovery of locomotor function and tissue repair in SCI by regulating gut homeostasis, promoting anti-inflammatory T cells, and affecting the balance of immune cells in the spinal cord.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Review
Immunology
Michael L. Dixon, Jonathan D. Leavenworth, Jianmei W. Leavenworth
Summary: Regulatory T-cells, particularly effector Tregs (eTregs), play a crucial role in maintaining self-tolerance and tissue homeostasis, with potential implications in tumor development. Understanding the mechanisms that modulate the stability and suppressive function of tumoral Tregs, such as eTregs and T-FR cells, can lead to the development of more effective cancer immunotherapies that target the tumor microenvironment while minimizing systemic side effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Grace L. Burns, Jessica K. Bruce, Kyra Minahan, Andrea Mathe, Thomas Fairlie, Raquel Cameron, Crystal Naudin, Prema M. Nair, Michael D. E. Potter, Mudar Zand Irani, Steven Bollipo, Robert Foster, Lay T. T. Gan, Ayesha Shah, Natasha A. Koloski, Paul S. Foster, Jay C. Horvat, Martin Veysey, Gerald Holtmann, Nick Powell, Marjorie M. Walker, Nicholas J. Talley, Simon Keely
Summary: This study found that patients with functional dyspepsia have increased Th2 and Th17 lymphocyte populations in the duodenal mucosa, and these cells are of effector and memory phenotype, indicating that the microinflammation in functional dyspepsia may be antigen-driven.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim
Summary: Patients with rheumatoid arthritis (RA) have higher levels of interleukin-18 (IL-18) and lower levels of IL-18 binding protein (IL-18BP) in their serum and synovial fluid compared to those with osteoarthritis (OA) or healthy controls. In vitro studies show that IL-18BP can correct the Th17/Treg imbalance in CD4(+) T cells of RA patients and reduce IL-17-induced osteoclastogenesis, suggesting therapeutic potential for RA treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Aenne Harberts, Constantin Schmidt, Joanna Schmid, Daniel Reimers, Friedrich Koch-Nolte, Hans-Willi Mittruecker, Friederike Raczkowski
Summary: IRF4 is essential for the activation and reactivation of CD8(+) memory T cells, but does not affect their overall survival. However, the formation and maintenance of CD8(+) tissue-resident memory T cells appears to depend on IRF4.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Allergy
Claire Barbieux, Mathilde Bonnet des Claustres, Matthias Fahrner, Evgeniya Petrova, Lam C. Tsoi, Olivier Gouin, Florent Leturcq, Pascale Nicaise-Roland, Christine Bole, Vivien Beziat, Emmanuelle Bourrat, Oliver Schilling, Johann E. Gudjonsson, Alain Hovnanian
Summary: This study comprehensively characterizes the skin, immune cells, and allergic phenotypes of Netherton syndrome through multiple molecular profiling methods. The results reveal abnormal epidermal proliferation and differentiation, as well as IL-17/IL-36 signatures in both NS-ILC and NS-SE. Distinct molecular features are found between nonlesion and lesion skin of each disease subtype. Serum cytokine profiling and immunophenotyping show different allergic responses in NS-ILC and NS-SE patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Daniel Lozano-Ojalvo, Scott R. Tyler, Carlos J. Aranda, Julie Wang, Scott Sicherer, Hugh A. Sampson, Robert A. Wood, A. Wesley Burks, Stacie M. Jones, Donald Y. M. Leung, Maria Curotto de Lafaille, M. Cecilia Berin
Summary: This study observed that oral immunotherapy can increase the frequency of Tregs in individuals with lasting clinical tolerance. It also found that the release of IL-2 from Th2 effector cells can induce delayed and persistent activation of Tregs, which could be significant for improving current oral immunotherapy approaches.
Article
Oncology
Alexandra Berger, Sarah J. Colpitts, Morgan Zych, Christopher J. Paige
Summary: We explored the use of IL-21 cell-based anti-leukemia treatment in a mouse model of acute lymphoblastic leukemia. Injection of IL-21-secreting 70Z/3 leukemia cells induced a strong anti-leukemia response and led to 100% survival rate. IL-21 secretion correlated with improved survival and the expansion of IL-21-secreting cells. The delivery of IL-21 showed the potential to induce a potent immune response and long-term immunity, making it an attractive candidate for cancer immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Shuangpeng Kang, Qiongli Wu, Binyan Yang, Changyou Wu
Summary: Tissue-resident memory gamma delta T cells in the uterus play a role in promoting trophocyte invasion through the production of IL-17. Estrogen enhances the population of gamma delta T cells in the uterus and increases IL-17 production through the estrogen receptor and interferon regulatory factor 4.
Article
Immunology
Chiara Della Bella, Antonio Antico, Maria Piera Panozzo, Nagaja Capitani, Luisa Petrone, Marisa Benagiano, Sofia D'Elios, Clotilde Sparano, Annalisa Azzurri, Sara Pratesi, Fabio Cianchi, Diana Ortiz-Princz, Mathijs Bergman, Nicola Bizzaro, Mario Milco D'Elios
Summary: This study investigated the gastric H+/K+-ATPase-specific Th17 responses and serum IL-17 cytokine subfamily in AIG patients, showing that gastric LPMCs from AIG patients are activated by H+/K+-ATPase and produce high levels of IL-17A and IL-17F, while serum IL-17A, IL-17F, IL-21, and IL-17E levels are significantly elevated in AIG patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Melissa G. Lechner, Zikang Zhou, Aline T. Hoang, Nicole Huang, Jessica Ortega, Lauren N. Scott, Ho -Chung Chen, Anushi Y. Patel, Rana Yakhshi-Tafti, Kristy Kim, Willy Hugo, Pouyan Famini, Alexandra Drakaki, Antoni Ribas, Trevor E. Angell, Maureen A. Su
Summary: Autoimmune toxicity is an increasing challenge in using immune checkpoint inhibitors for cancer treatment. This study investigated the immune infiltrates in ICI-thyroiditis patients and identified a dominant population of cytotoxic CD8+ T cells. The researchers also found that interleukin-21 played a crucial role in the formation of these thyrotoxic CD8+ T cells and validated the findings in a mouse model. These findings provide insights into the mechanisms and potential therapeutic targets for individuals with IRAEs.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Jaehwan Kim, Jongmi Lee, Xuan Li, Norma Kunjravia, Darshna Rambhia, Inna Cueto, Katherine Kim, Vasuma Chaparala, Younhee Ko, Sandra Garcet, Wei Zhou, Junyue Cao, James G. Krueger
Summary: This study provides translational evidence that systemic IL-17A blockade promotes regulatory gene expression in immune cell subsets in human psoriasis skin, indicating its potential as a therapeutic approach for psoriasis.
FRONTIERS IN IMMUNOLOGY
(2023)
