Review
Biochemistry & Molecular Biology
Marcelle Mehu, Chandrakala Aluganti Narasimhulu, Dinender K. Singla
Summary: Atherosclerosis is a chronic disease characterized by damage to the intima, inflammatory cell recruitment, and lipid accumulation followed by calcification and plaque rupture. Inflammation is believed to play a crucial role in the development and progression of the disease. This paper discusses the various types of inflammatory cells involved in atherosclerosis and their significance in the disease's development and progression. Understanding the role of these cells at different stages of the disease provides valuable insights for targeted therapy.
Article
Immunology
Chun I. Yu, Jan Martinek, Te-Chia Wu, Kyung In Kim, Joshy George, Elaheh Ahmadzadeh, Rick Maser, Florentina Marches, Patrick Metang, Pierre Authie, Vanessa K. P. Oliveira, Victor G. Wang, Jeffrey H. Chuang, Paul Robson, Jacques Banchereau, Karolina Palucka
Summary: Metastasis of melanoma significantly worsens prognosis; the CD33+CD11b+CD117+ myeloid cells could serve as a potential biomarker and therapeutic target for metastatic melanoma.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Cell Biology
Jenying Deng, Jason B. Fleming
Summary: Most immunotherapy drugs target T cell surface proteins to enhance their tumor-killing activity, but this approach has limited success in certain solid tumors. Myeloid-related innate immunity plays a role in tumor progression and understanding this field may lead to new therapeutic options. Myeloid cells can differentiate into pro-inflammatory or anti-inflammatory forms depending on the tumor microenvironment. In this review, the relationship between cancer cells and myeloid cells in the tumor immune microenvironment, and the development of immunotherapeutic strategies targeting myeloid-related innate immunity will be discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Fisheries
Mayumi Fernanda Aracati, Susana Luporini de Oliveira, Leticia Franchin Rodrigues, Camila Carlino da Costa, Alessandra Cristina de Moraes, Ed Johnny da Rosa Prado, Dayanne Carla Fernandes, Thais Heloisa Vaz Farias, Silas Fernandes Eto, Ives Charlie-Silva, Marco Antonio de Andrade Belo
Summary: This study evaluated the anti-inflammatory effect of zafirlukast, an antagonist of cysteinyl leukotriene receptors, in Oreochromis niloticus during acute inflammatory reaction induced by Aeromonas hydrophila bacterins. The results showed that zafirlukast treatment dose-dependently reduced the accumulation of inflammatory cells, particularly granulocytes and macrophages. Zafirlukast-treated fish also exhibited decreased blood leukocyte counts and reactive oxygen species production.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Pin-yi Liu, Hui-qin Li, Meng-qi Dong, Xin-ya Gu, Si-yi Xu, Sheng-nan Xia, Xin-yu Bao, Yun Xu, Xiang Cao
Summary: Properdin activates Mincle receptors on microglia to drive inflammatory responses, exacerbating brain injury in ischemic stroke patients. The interaction between properdin and Mincle on microglia may be a potential therapeutic target for improving ischemic stroke prognosis.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Biochemistry & Molecular Biology
Inaya Hayek, Valentin Schatz, Christian Bogdan, Jonathan Jantsch, Anja Luehrmann
Summary: The tissue microenvironment, including factors like oxygen concentration, plays a crucial role in host-pathogen interactions. Hypoxia and hypoxia-inducible factors (HIF) have been identified as important factors affecting both pathogens and hosts, influencing inflammatory and antimicrobial activities in myeloid cells, bacterial responses to low oxygen conditions, and the metabolism of immune cells. Additionally, the consequences of hypoxia and HIF alpha activation on various invading pathogens like Pseudomonas aeruginosa, Mycobacterium tuberculosis, Coxiella burnetii, Salmonella enterica, and Staphylococcus aureus, including how these pathogens sense and respond to hypoxic environments, are discussed.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Shranjit S. Lail, Corey R. Arnold, Luiz G. N. de Almeida, Neil McKenna, Jose A. Chiriboga, Antoine Dufour, Amy L. Warren, Robin Michael Yates
Summary: This study discusses the use of Hoxb8 and Hoxa9 to immortalize differentiation-competent myeloid cell progenitors in mice as an alternative to primary macrophages and immortalized macrophage-like cell lines. The study found that macrophages derived from Hoxb8/Hoxa9 immortalized progenitors are similar to bone marrow-derived macrophages and can be used in functional studies such as phagosome analysis. The study also proposes a standardized nomenclature for cells derived from the Hoxb8/Hoxa9 system.
Article
Multidisciplinary Sciences
Laura J. Pallett, Leo Swadling, Mariana Diniz, Alexander A. A. Maini, Marius Schwabenland, Adria Dalmau Gasull, Jessica Davies, Stephanie Kucykowicz, Jessica K. K. Skelton, Niclas Thomas, Nathalie M. M. Schmidt, Oliver E. E. Amin, Upkar S. S. Gill, Kerstin A. A. Stegmann, Alice R. R. Burton, Emily Stephenson, Gary Reynolds, Matt Whelan, Jenifer Sanchez, Roel de Maeyer, Clare Thakker, Kornelija Suveizdyte, Imran Uddin, Ana M. M. Ortega-Prieto, Charlotte Grant, Farid Froghi, Giuseppe Fusai, Sabela Lens, Sofia Perez-del-Pulgar, Walid Al-Akkad, Giuseppe Mazza, Mahdad Noursadeghi, Arne Akbar, Patrick T. F. Kennedy, Brian R. R. Davidson, Marco Prinz, Benjamin M. M. Chain, Muzlifah Haniffa, Derek W. W. Gilroy, Marcus Dorner, Bertram Bengsch, Anna Schurich, Mala K. K. Maini
Summary: CD14(+)CD8(+) T cells in the liver exhibit immunomodulatory features and play a role in liver transplantation, infection, and tumors. These cells have high levels of IL-10 and IL-2 production, as well as enhanced antiviral/anti-tumor effector function. Additionally, these cells can enhance the tumor-killing ability of CD8(+) T cells by acquiring the lipopolysaccharide receptor complex from mononuclear phagocytes. Bacterial products and tissue stromal factors can tune liver immunity by driving myeloid instruction of CD8(+) T cells.
Article
Immunology
Lucia Pena-Perez, Shabnam Kharazi, Nicolai Frengen, Aleksandra Krstic, Thibault Bouderlique, Julia Hauenstein, Minghui He, Ece Somuncular, Xiaoze Li Wang, Carin Dahlberg, Charlotte Gustafsson, Ann-Sofie Johansson, Julian Walfridsson, Nadir Kadri, Petter Woll, Marcin Kierczak, Hong Qian, Lisa Westerberg, Sidinh Luc, Robert Mansson
Summary: The study reveals the crucial roles of FOXO3 and FOXO1 in B cell development. Loss of FOXO3 impairs B cell development, while loss of FOXO1 hinders B cell commitment. Simultaneous loss of FOXO1 and FOXO3 results in the complete loss of the B cell lineage.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Sonia Ghilas, Ryan O'Keefe, Lisa Anna Mielke, Dinesh Raghu, Michael Buchert, Matthias Ernst
Summary: The gut epithelium serves as a physical barrier and facilitates interactions between bacteria, immune cells, and immune system components. Maintaining the integrity of the epithelial barrier is crucial for health and involves a complex response from various immune cells. Imbalance in this process can lead to chronic inflammation, tumorigenesis, and compromised immune control. In this article, the roles of innate lymphoid cells, macrophages, and dendritic cells in maintaining the epithelial barrier are discussed, highlighting their connection to both innate and adaptive immunity. These interactions impact the gut epithelium's renewal capacity, protect against tumor formation, and influence the gut microbiome, which contributes to cellular homeostasis in the gut.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Lauren E. Hillers-Ziemer, Abbey E. Williams, Amanda Janquart, Caitlin Grogan, Victoria Thompson, Adriana Sanchez, Lisa M. Arendt
Summary: Obesity promotes rapid growth and metastases of mammary tumors in mice by increasing recruitment of myeloid lineage cells and deposition of collagen fibers within the lungs. Lung stromal cells isolated from obese mice show higher expression of extracellular matrix proteins and inflammatory cytokines, facilitating metastatic growth prior to tumor formation. Understanding these mechanisms may provide new therapeutic options for obese breast cancer patients.
Review
Medicine, General & Internal
Iman M. M. Talaat, Noha M. M. Elemam, Shroque Zaher, Maha Saber-Ayad
Summary: Colorectal cancer is a prevalent cancer type worldwide, and the immune cells within the tumor microenvironment play a crucial role in its initiation and progression. Immune checkpoint molecules are highlighted as potential targets for immunotherapy in colorectal cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Developmental Biology
Ankita Thawani, Helen R. Maunsell, Hongyuan Zhang, Harinarayana Ankamreddy, Andrew K. Groves
Summary: The Foxi3 transcription factor plays an important role in early development by restricting progenitor cells at the neural plate border to a placodal and epidermal fate.
Article
Immunology
Xiaomin Zhang, Xiaokai Zhang, Xiaomei Song, Chuanying Xiang, Chunmei He, Yu Xie, Yangyang Zhou, Ning Wang, Gang Guo, Weijun Zhang, Yan Li, Kaiyun Liu, Quanming Zou, Hong Guo, Yun Shi
Summary: Cytokines play a vital role in inflammatory bowel disease, and this study focused on IL17B in the pathogenesis of colitis. The findings showed increased IL17B expression in inflamed colon tissues of IBD patients. IL17B deficiency resulted in severe colitis, while treatment with recombinant IL17B alleviated the disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Peter Wieghofer, Nora Hagemeyer, Roman Sankowski, Anja Schlecht, Ori Staszewski, Lukas Amann, Markus Gruber, Jana Koch, Annika Hausmann, Peipei Zhang, Stefaniya Boneva, Takahiro Masuda, Ingo Hilgendorf, Tobias Goldmann, Chotima Boettcher, Josef Priller, Fabio M. Rossi, Clemens Lange, Marco Prinz
Summary: The study identified different transcriptional states of myeloid subsets in the eye, particularly disease-specific macrophage subpopulations with distinct molecular signatures during choroidal neovascularization, a hallmark of neovascular age-related macular degeneration (AMD). These findings provide new insights into the innate immune system in the eye and potential therapeutic targets for ophthalmological diseases.
