期刊
SEMINARS IN IMMUNOLOGY
卷 20, 期 5, 页码 276-285出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2008.07.001
关键词
Cancer immunotherapy; Tumor antigens; Specificity; Glycosylation; Cosmc
类别
资金
- NIH [P01-CA97296, R01-CA22677, R01-CA37516]
- NATIONAL CANCER INSTITUTE [R01CA022677, R01CA037156, P01CA097296] Funding Source: NIH RePORTER
From the earliest days in the field of tumor immunology three questions have been asked: do cancer cells express tumor-specific antigens, does the immune system recognize these antigens and if so, what is their biochemical nature? We now know that truly tumor-specific antigens exist, that they are caused by somatic mutations, and that these antigens can induce both humoral and cell-mediated immune responses. Because tumor-specific antigens are exclusively expressed by the cancer cell and are often crucial for tumorigenicity, they are ideal targets for anti-cancer immunotherapy. Nevertheless, the antigens that are targeted today by anti-tumor immunotherapy are not tumor-specific antigens, but antigens that are normal molecules also expressed by normal tissues (so-called tumor-associated antigens). If tumor-specific antigens exist and are ideal targets for immunotherapy, why are they not being targeted? In this review, we summarize current knowledge of tumor-specific antigens: their identification, immunological relevance and clinical use. We discuss novel tumor-specific epitopes and propose new approaches that could improve the success of cancer immunotherapy, especially for the treatment of solid tumors. (C) 2008 Elsevier Ltd. All rights reserved.
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