期刊
SEMINARS IN FETAL & NEONATAL MEDICINE
卷 19, 期 1, 页码 15-26出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2013.10.004
关键词
Cervical cerclage; Cervical length; Cervical ultrasound; Short cervix; Ultrasound; Vaginal progesterone
类别
资金
- Perinatology Research Branch
- Division of Intramural Research
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
- Department of Health and Human Services (NICHD/NIH)
- NICHD, NIH [HHSN275201300006C]
Preterm birth is the leading cause of perinatal morbidity and mortality worldwide, and its prevention is an important healthcare priority. Preterm parturition is one of the 'great obstetrical syndromes' and is caused by multiple etiologies. One of the mechanisms of disease is the untimely decline in progesterone action, which can present as a clinically silent sonographic short cervix in the midtrimester. The detection of a short cervix in the midtrimester is a powerful risk factor for preterm delivery. Vaginal progesterone can reduce the rate of preterm delivery by 45% and the rate of neonatal morbidity (admission to the neonatal intensive care unit, respiratory distress syndrome, need for mechanical ventilation, etc.). To prevent one case of spontaneous preterm birth <33 weeks of gestation, 11 patients with a short cervix would need to be treated (based on an individual patient meta-analysis). Vaginal progesterone reduces the rate of spontaneous preterm birth in women with a short cervix, both with and without a prior history of preterm birth. In patients with a prior history of preterm birth, vaginal progesterone is as effective as cervical cerclage to prevent preterm delivery. 17 alpha-Hydroxyprogesterone caproate has not been shown to be effective in reducing the rate of spontaneous preterm birth in women with a short cervix. Published by Elsevier Ltd.
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