Article
Medicine, Research & Experimental
Jinsen Zheng, Rongzhang Dou, Xinyao Zhang, Bo Zhong, Chenggang Fang, Qian Xu, Ziyang Di, Sihao Huang, Zaihuan Lin, Jialin Song, Shuyi Wang, Bin Xiong
Summary: The overexpression of LINC00543 in colorectal cancer tissues is associated with advanced TNM stage and poorer prognosis of CRC patients. LINC00543 promotes tumorigenesis and metastasis of CRC cells by enhancing EMT and remodeling the TME.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Rania Shalaby, Sally Ibrahim, Ali A. W. Kotb, Safaa Baz, Layla Hafed, Olfat Shaker, Salsabeel Afifi
Summary: This study aimed to determine the diagnostic accuracy of long non-coding RNA MALAT1 in saliva for oral squamous cell carcinoma (OSCC) and assess its relationship with the salivary expression of microRNA-124. The results showed that OSCC patients had higher expression of MALAT1 and lower expression of miRNA-124 in saliva compared to healthy controls. Salivary MALAT1 acted as a sponge for miRNA-124 and showed potential as a biomarker for OSCC, with high sensitivity and specificity.
Article
Biochemistry & Molecular Biology
Liping Zhang, Junyi Hu, Bahar I. Meshkat, Kenneth W. Liechty, Junwang Xu
Summary: In diabetic wounds, MALAT1 and TGF-β1 expression are significantly up-regulated, and knockdown of MALAT1 attenuates TGF-β1-induced EMT in HaCaT cells by inducing the expression of the critical transcription factor ZEB1, providing new insights into the pathogenesis of diabetic wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Qingnan Wu, Weimin Zhang, Yan Wang, Qingjie Min, Hongyue Zhang, Dezuo Dong, Qimin Zhan
Summary: The study revealed that MAGE-C3 is overexpressed in ESCC tissues, and is significantly associated with lymphatic metastasis risk and poor survival in ESCC patients. MAGE-C3 promotes tumor metastasis by activating EMT, repressing antitumor immunity, and enhancing IFN-gamma signaling. Additionally, MAGE-C3 may serve as a potential prognostic marker and therapeutic target.
CANCER COMMUNICATIONS
(2021)
Article
Oncology
Xinyue Zhang, Xi Chen, Dongyuan Sun, Ning Song, Minmin Li, Wentian Zheng, Yang Yu, Gang Ding, Yingying Jiang
Summary: ENAH-202 is significantly upregulated in OSCC tissues and cells. It promotes OSCC cell proliferation, migration, and invasion both in vitro and in vivo. ENAH-202 regulates the expression of ENAH and EMT-related proteins, and it promotes the transcription of Vimentin by binding with ZNF502, which contributes to OSCC progression.
Article
Biochemistry & Molecular Biology
Ching-Chung Ko, Yao-Yu Hsieh, Pei-Ming Yang
Summary: Epithelial-to-mesenchymal transition (EMT) is a biological process that promotes cancer cell dissemination and drug resistance. This study revealed that overexpression of MIR31HG in pancreatic ductal adenocarcinoma (PDAC) patients is associated with poorer disease-free survival, as well as upregulation of genes related to TGF beta signaling and EMT. In vitro experiments further demonstrated that TGF beta induces MIR31HG expression and knockdown of MIR31HG reverses TGF beta-induced EMT phenotypes and cancer cell migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xin Yue, Wen-ying Wu, Ma Dong, Meng Guo
Summary: MALAT1 is highly expressed in breast cancer tissues and cells, promoting proliferation, migration, invasion, and doxorubicin resistance. Through targeting miR-570-3p, MALAT1 plays a pivotal role in regulating breast cancer progression and drug resistance.
BIOMEDICAL JOURNAL
(2021)
Article
Oncology
Yan Zhao, Jiajia Gao, Xiufeng Xie, Peng Nan, Fang Liu, Yulin Sun, Xiaohang Zhao
Summary: The study demonstrated that BACH1 is overexpressed in ESCC tissues, associated with poor prognosis. BACH1 enhances migration and invasion in ESCC, promotes EMT and angiogenesis, and may serve as a promising therapeutic target or molecular marker in ESCC.
Article
Multidisciplinary Sciences
Wenli Zang, Junchao Liu, Fengxue Geng, Dongjuan Liu, Shuwei Zhang, Yuchao Li, Yaping Pan
Summary: This study found that butyrate can promote the migration and invasion of oral squamous cell carcinoma (OSCC) cells by inducing epithelial-mesenchymal transition (EMT), indicating that butyrate may contribute to the metastasis of OSCC.
Article
Cell Biology
Yuansheng Duan, Kai Yue, Beibei Ye, Peng Chen, Jin Zhang, Qinghua He, Yue Wu, Qingchuan Lai, Hong Li, Yansheng Wu, Chao Jing, Xudong Wang
Summary: Long non-coding RNAs (LncRNAs), particularly the MALAT1, are significantly upregulated in HNSCC tissues and associated with poor prognosis. Targeting MALAT1 can inhibit HNSCC proliferation and metastasis by activating EZH2/STAT3/Akt axis and promoting the stabilization and activation of beta-catenin and NF-kappa B. These findings suggest MALAT1 as a promising therapeutic target for HNSCC treatment.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Wei-Kun Shi, Yun-Hao Li, Xue-Shan Bai, Guo-Le Lin
Summary: This study used bioinformatics to search for genes associated with the prognosis of colorectal cancer (CRC), and identified several genes that may be important for CRC prognosis. Further experiments confirmed the role of one of these genes, CDKN2A, in colorectal cancer cells.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Meghdad Eslami, Saba Khazeni, Xaniar Mohammadi Khanaghah, Mohammad Hossein Asadi, Mohamad Amin Ansari, Javad Hayati Garjan, Mohammad Hassan Lotfalizadeh, Mobina Bayat, Mohammad Taghizadieh, Seyed Pouya Taghavi, Michael R. Hamblin, Javid Sadri Nahand
Summary: Oral cancer is a prevalent tumor with increasing mortality and incidence. MicroRNAs (miRNAs) and non-coding RNAs (lncRNAs and circRNAs) play crucial roles in controlling cancer metastasis. MiRNAs can inhibit or stimulate metastasis at various stages, while lncRNAs and circRNAs regulate metastasis by interacting with miRNAs. Overall, non-coding RNAs, particularly miRNAs, offer potential for innovative therapeutic methods to control oral cancer metastasis.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Wei Liu, Shu Tan, Xiaoxu Bai, Shihong Ma, Xiuwei Chen
Summary: LINC01215 was identified as an upregulated lncRNA in EOC, and its interaction with methylation-related proteins was found to downregulate the expression of RUNX3. Silencing of LINC01215 resulted in increased expression of RUNX3, suppressing cell proliferation, migration, invasion, EMT, tumor growth, and LNM. Downregulating LINC01215 could promote the methylation of RUNX3, thereby inhibiting EOC progression.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Eunjeong Kang, Jihye Seo, Haelim Yoon, Sayeon Cho
Summary: Epithelial-mesenchymal transition (EMT) plays a key role in both normal development and pathology, regulated by EMT-inducing transcription factors (EMT-TFs) to control the up- and down-regulation of specific proteins. This process is crucial for cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anqing Wu, Jiaxin Tang, Ziyang Guo, Yingchu Dai, Jing Nie, Wentao Hu, Ningang Liu, Caiyong Ye, Shihong Li, Hailong Pei, Guangming Zhou
Summary: This study revealed that LNC CRYBG3 regulates non-small cell lung cancer metastasis by promoting the transcription factor MDM2, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)