期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 28, 期 -, 页码 22-30出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.03.004
关键词
HB-EGF; HB-EGF processing; ADAM; Wound healing; Reproductive biology; Transgenic mice; Angiogenesis; Tumor formation; Adipogenesis
资金
- Miami University Biology Department
HB-EGF is a member of the EGF family of ligands that is initially synthesized as a membrane-bound growth factor termed, proHB-EGF. The membrane bound proHB-EGF undergoes extensive proteolytic processing by several metalloproteinases capable of stimulating cellular proliferation. Soluble, mature HB-EGF binds to and activates EGF receptors. HB-EGF is a critical molecular component to a number of normal physiological processes including but not limited to tissue injury and wound healing, reproduction, angiogenesis and recently, adipogenesis. Misexpression of HB-EGF is linked to tumor formation and cancer including hepatocellular, pancreatic, gastric, breast, colon and melanoma, gliomas and glioblastomas. HB-EGF is a likely tool for therapeutic approaches to enhance treatment of injuries as well as a target for prevention of several cancers and obesity. (C) 2014 Elsevier Ltd. All rights reserved.
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