期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 32, 期 -, 页码 2-10出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.03.010
关键词
Splicing regulation; RNA polymerase II; CTD; Chromatin; Nucleosome
资金
- Fundacao para a Ciencia e Tecnologia (FCT), Portugal [PTDC/BIA-BCM/111451/2009, PTDC/BIM-ONC/0384/2012, PTDC/SAU-GMG/118189/2010]
- Fundação para a Ciência e a Tecnologia [PTDC/BIA-BCM/111451/2009, PTDC/BIM-ONC/0384/2012] Funding Source: FCT
Here we review recent findings showing that chromatin organization adds another layer of complexity to the already intricate network of splicing regulatory mechanisms. Chromatin structure can impact splicing by either affecting the elongation rate of RNA polymerase II or by signaling the recruitment of splicing regulatory proteins. The C-terminal domain of the RNA polymerase II largest subunit serves as a coordination platform that binds factors required for adapting chromatin structure to both efficient transcription and processing of the newly synthesized RNA. Reciprocal interconnectivity of steps required for gene activation plays a critical role ensuring efficiency and fidelity of gene expression. (C) 2014 Elsevier Ltd. All rights reserved.
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