Article
Cell Biology
Feng-Liu Wang, Ya-Lan Tan, Lukas Wallrad, Xin-Qiao Du, Anna Eickelkamp, Zhi-Fang Wang, Ge-Feng He, Felix Rehms, Zhen Li, Jian-Pu Han, Ina Schmitz-Thom, Wei-Hua Wu, Joerg Kudla, Yi Wang
Summary: The mechanisms underlying plant K+ sensing and downstream responses have been revealed in this study, showing a defined K+ sensing niche and a low-K+ signaling axis that trigger ROS signals and related pathways. These mechanisms coordinate plant growth and development while regulating nutrient uptake by roots.
DEVELOPMENTAL CELL
(2021)
Review
Biochemistry & Molecular Biology
Jessica Bouviere, Rodrigo S. Fortunato, Corinne Dupuy, Joao Pedro Werneck-de-Castro, Denise P. Carvalho, Ruy A. Louzada
Summary: Physical exercise induces acute and adaptative responses at the cellular and systemic levels through the modulation of various signaling pathways in skeletal muscle. Antioxidants can blunt these adaptations, highlighting the crucial role of ROS in exercise. Understanding the balance between beneficial and harmful effects of ROS during and after exercise is a challenging question in exercise biology.
Article
Food Science & Technology
Xiangyuan Liu, Li Song
Summary: DDT exposure can cause liver cell toxicity, which can be alleviated by quercetin through inhibition of reactive oxygen species production.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Hidefumi Iwashita, Erika Castillo, Marco S. Messina, Raymond A. Swanson, Christopher J. Chang
Summary: A new tandem activity-based sensing and labeling strategy for H2O2 imaging has been reported, allowing capture and permanent recording of localized H2O2 fluxes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Hidefumi Iwashita, Erika Castillo, Marco S. Messina, Raymond A. Swanson, Christopher J. Chang
Summary: This study presents an advanced strategy for imaging H2O2 using a tandem activity-based sensing and labeling approach, allowing capture and recording of localized H2O2 fluxes. It enables visualization of transcellular redox signaling and provides a starting point for designing chemical probes with high spatial fidelity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Anna D. Manis, Oleg Palygin, Elena Isaeva, Vladislav Levchenko, Peter S. LaViolette, Tengis S. Pavlov, Matthew R. Hodges, Alexander Staruschenko
Summary: The K(ir)5.1 channel plays a crucial role in the brain, and its knockout leads to seizures and mortality. SSKcnj16-/- rats showed increased light sensitivity and reproducible audiogenic seizures, highlighting a distinct role for K(ir)5.1 channels in the brain.
Article
Medicine, Research & Experimental
Jing Liao, Biyan Peng, Guangyi Huang, Chunli Diao, Yuanjun Qin, Yiyi Hong, Jiali Lin, Yunru Lin, Li Jiang, Ningning Tang, Fen Tang, Jiamin Liang, Jun Zhang, Yumei Yan, Qi Chen, Zhou Zhou, Chaolan Shen, Wei Huang, Kongqian Huang, Qianqian Lan, Ling Cui, Haibin Zhong, Fan Xu, Min Li, Yantao Wei, Peng Lu, Mingyuan Zhang
Summary: The study investigates the role of NOX4 inhibitor GLX351322 in acute ocular hypertension-induced retinal injury. The inhibitor reduced ROS overproduction, inhibited inflammatory factor release, and suppressed glial cell activation and hyperplasia. It also improved retinal degeneration and function by inhibiting the redox-sensitive factor pathway mediated by ROS overproduction.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Plant Sciences
Marjorie Guichard, Sebastien Thomine, Jean-Marie Frachisse
Summary: The study of mechanosensitive channels has made significant progress in the past two decades, and its importance has been recognized with the award of the Nobel Prize. This article summarizes the fundamental properties and mode of operation of MS channels, provides an update on the knowledge of MS channel families in plants, and discusses their roles and functions.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Article
Neurosciences
Hui Sun, Mayur J. Patil, Fei Ru, Sonya Meeker, Bradley J. Undem
Summary: This study demonstrates that the K(v)1/D-type potassium current (I-D) plays a critical role in regulating the activation of bronchopulmonary vagal afferent nerves. The I-D channels stabilize the membrane potential, counterbalance subthreshold depolarization, and promote the adaptation of action potential firings. Down-regulation of I-D channels may contribute to enhanced C-fiber activity in airway diseases.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Biochemistry & Molecular Biology
Maria Pilarska, Dorothea Bartels, Ewa Niewiadomska
Summary: This research investigated differences in the regulation of NOX-dependent signalling under salt stress between the halophyte Eutrema salsugineum and the glycophyte Arabidopsis thaliana. The study revealed distinct expression patterns of NOX genes and differences in NOX activity between the two plants under salinity, implicating modified regulation possibly through ABA- and/or ethylene-dependent pathways in the halophyte.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Noemi Esteras, Franziska Kundel, Giuseppe F. Amodeo, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov
Summary: The aggregation and phosphorylation of tau protein can lead to abnormal signal transduction and disruption of cellular homeostasis. Prolonged aggregation of tau can stimulate reactive oxygen species production and induce calcium signals in neurons, potentially leading to toxicity.
Article
Medicine, Research & Experimental
David Coe, Thanushiyan Poobalasingam, Hongmei Fu, Fabrizia Bonacina, Guosu Wang, Valle Morales, Annalisa Moregola, Nico Mitro, Kenneth Cp Cheung, Eleanor J. Ward, Suchita Nadkarni, Dunja Aksentijevic, Katiuscia Bianchi, Giuseppe Danilo Norata, Melania Capasso, Federica M. Marelli-Berg
Summary: The voltage-gated hydrogen channel 1 (Hvcn1) plays a critical role in protecting naive T cells from intracellular acidification during priming. Deficiency of Hvcn1 in CD4(+) and CD8(+) T cells leads to differences in T cell receptor signaling, cellular division, and death during the transition from naive to primed T cells. This is due to the different metabolic responses to intracellular acidification in CD4(+) and CD8(+) T cells.
Article
Physiology
Caspar Schiffers, Lennart K. A. Lundblad, Milena Hristova, Aida Habibovic, Christopher M. Dustin, Nirav Daphtary, Minara Aliyeva, David J. Seward, Yvonne M. W. Janssen-Heininger, Emiel F. M. Wouters, Niki L. Reynaert, Albert van der Vliet
Summary: Aging is associated with a decline in innate airway injury responses to external nonmicrobial triggers, primarily due to downregulation of DUOX1 and its redox-dependent signaling pathways. However, the impact of DUOX1 deficiency on age-related airspace enlargement and decline in lung function varies between different C57BL6 substrains, possibly related to metabolic alterations due to differences in NNT function.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Shuguo Hou, Derui Liu, Shijia Huang, Dexian Luo, Zunyong Liu, Qingyuan Xiang, Ping Wang, Ruimin Mu, Zhifu Han, Sixue Chen, Jijie Chai, Libo Shan, Ping He
Summary: The study reveals that the Arabidopsis receptor kinase MIK2 can recognize the conserved signature motif from both plants and fungi/bacteria, triggering immune responses and affecting root development.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Yorick Janssens, Nathan Debunne, Anton De Spiegeleer, Evelien Wynendaele, Marta Planas, Lidia Feliu, Alessandra Quarta, Christel Claes, Debby Van Dam, Peter Paul De Deyn, Peter Ponsaerts, Matthew Blurton-Jones, Bart De Spiegeleer
Summary: QSPs are bacterial peptides produced by Gram-positive bacteria that can act as interbacterial communication signals and also affect the host. This study investigated the microglial activating properties of a selected QSP PapRIV, demonstrating its ability to cross the gut-brain axis and activate microglia cells in vitro, suggesting a potential role in gut-brain interaction.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Nicolle J. Domnik, Elias T. Polymeropoulos, Nicholas G. Elliott, Peter B. Frappell, John T. Fisher
FRONTIERS IN PHYSIOLOGY
(2016)
Review
Physiology
Denis E. O'Donnell, Amany F. Elbehairy, Danilo C. Berton, Nicolle J. Domnik, J. Alberto Neder
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Physiology
Amany F. Elbehairy, Katherine A. Webb, Pierantonio Laveneziana, Nicolle J. Domnik, J. Alberto Neder, Denis E. O'Donnell
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Hongtao Liu, Josefa Hofmann, Inbar Fish, Benjamin Schaake, Katrin Eitel, Amelie Bartuschat, Jonas Kaindl, Hannelore Rampp, Ashutosh Banerjee, Harald Huebner, Mary J. Clark, Sandra G. Vincent, John T. Fisher, Markus R. Heinrich, Kunio Hirata, Xiangyu Liu, Roger K. Sunahara, Brian K. Shoichet, Brian K. Kobilka, Peter Gmeiner
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Respiratory System
Amany F. Elbehairy, Azmy Faisal, Hannah McIsaac, Nicolle J. Domnik, Kathryn M. Milne, Matthew D. James, J. Alberto Neder, Denis E. O'Donnell
Summary: Patients with advanced COPD experience higher breathing discomfort, work of breathing, and respiratory effort in both sitting and supine positions compared to healthy controls. In the supine position, patients show decreased lung compliance, increased breathing discomfort, inspiratory work of breathing, and neuroventilatory uncoupling.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Respiratory System
Devin B. Phillips, Matthew D. James, Amany F. Elbehairy, Kathryn M. Milne, Sandra G. Vincent, Nicolle J. Domnik, Juan P. De-Torres, J. Alberto Neder, Denis E. O'Donnell
Summary: The study suggests that in COPD patients, a combination of low resting DLCO and high exercise ventilatory requirements may be associated with early dynamic mechanical constraints, dyspnea, and exercise limitation.
Article
Physiology
Nicolle J. Domnik, Sami Torbey, Geoffrey E. J. Seaborn, John T. Fisher, Selim G. Akl, Damian P. Redfearn
Summary: The development of the novel MAST algorithm enables automated, accurate, and noise-robust single-channel R-wave detection from chronically instrumented mice, leading to improved accuracy and reduced effort in studying heart rate indices. Additionally, the algorithm provides a foundational code for potential translation to other mammals, ectothermic vertebrates, and birds.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2021)
Article
Physiology
Sandra G. Vincent, John T. Fisher
Summary: Activation of skeletal muscle M(3)Dq leads to significant impact on cardiopulmonary function, including a drop in heart rate, reduced locomotor activity, and decreased pulmonary minute ventilation, possibly linked to metabolic responses and torpor initiation.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2021)
Article
Physiology
Nicolle J. Domnik, Devin B. Phillips, Matthew D. James, Grace A. Ayoo, Sarah M. Taylor, Robin E. Scheeren, Amanda T. Di Luch, Kathryn M. Milne, Sandra G. Vincent, Amany F. Elbehairy, Sophie J. Crinion, Helen S. Driver, J. Alberto Neder, Denis E. O'Donnell
Summary: The study aimed to assess the impact of night-time increases in mechanical loading on respiratory muscle function in COPD patients and whether compensatory increases in inspiratory neural drive are adequate to maintain ventilatory output and arterial oxygen saturation during sleep. The results showed that despite the progressive mechanical loading and reduced wakefulness drive, COPD patients were able to maintain adequate inspiratory effort and oxygen saturation during sleep. This suggests that there is continued or increased activation of extra-diaphragmatic muscles even during sleep in COPD.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Review
Respiratory System
Alexandra McCartney, Devin Phillips, Matthew James, Olivia Chan, J. Alberto Neder, Juan P. de-Torres, Nicolle J. Domnik, Sophie J. Crinion
Summary: This review critically discusses the mechanisms by which sleep influences ventilatory neural drive and mechanical consequences in healthy subjects and hypercapnic patients with advanced COPD. It highlights the importance of investigating sleep's impact on breathing for the use of nocturnal noninvasive positive-pressure ventilation.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Respiratory System
Renata D. Marques, Danilo C. Berton, Nicolle J. Domnik, Helen Driver, Amany F. Elbehairy, Michael Fitzpatrick, Denis E. O'Donnell, Simone Fagondes, Jose Alberto Neder
Summary: A study on COPD patients found that pulmonary function variables were weakly related to sleep quality and had a weaker direct relationship with PSG outcomes. Nocturnal oxygen saturation and airflow limitation were associated with sleep efficiency, while DLCO was related to sleep onset latency and REM sleep time.
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2021)
Meeting Abstract
Respiratory System
Nicolle Domnik, Matthew James, Casey Ciavaglia, Helen Driver, Sophie Crinion, J. Alberto Neder, Denis O'Donnell
EUROPEAN RESPIRATORY JOURNAL
(2019)
Meeting Abstract
Critical Care Medicine
N. Domnik, M. E. James, C. Ciavaglia, J. F. Garvey, H. S. Driver, K. Webb, D. E. O'Donnell
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Meeting Abstract
Biochemistry & Molecular Biology
Nicolle Domnik, Sandra Vincent, R. John MacLeod, Ernest Cutz, John Fisher
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
