Article
Agriculture, Dairy & Animal Science
Maximiliano Muller, Chenjing Xu, Marta Navarro, Nuria Elias Masiques, Alan Tilbrook, Robert van Barneveld, Eugeni Roura
Summary: This study aimed to validate the ex vivo model by testing the amino acids of interest in live pigs. The results showed that Leu increased plasma CCK levels, Phe sustained long-lasting increase in GLP-1 levels, and there was a positive correlation between CCK and GLP-1 levels for Phe treated pigs. These findings are important for commercial feed formulation practices, particularly in regards to the importance of aromatic amino acids in pig nutrition.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Chemistry, Medicinal
Qimeng Yang, Feng Zhou, Xuelin Tang, Jialing Wang, Hui Feng, Wen Jiang, Luofan Jin, Neng Jiang, Yongliang Yuan, Jing Han, Zhiming Yan
Summary: The combined use of gastrointestinal hormones for treating metabolic diseases is receiving increasing attention. A study reported a series of novel GLP-1R/CCK-1R co-agonists and showed that they exerted improved effects on metabolic improvements in obese rodents. These findings suggest a promising combination therapy strategy for treating metabolic disorders.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Neng Jiang, Lin Jing, Qing Li, Sibiao Su, Qimeng Yang, Feng Zhou, Xinyu Chen, Jing Han, Chunli Tang, Weizhong Tang
Summary: Dual activation of the glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-1R) can potentially lead to effective therapy for diabetes and obesity. Novel peptides with dual activity on GLP-1R and GCGR were discovered through rational design, with xGLP/GCG-15 showing promising anti-obesity and anti-diabetic effects in preclinical studies.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Anatomy & Morphology
Yvette Ruska, Anett Szilvasy-Szabo, Dora Kovari, Andrea Kadar, Lilla Macsai, Richard Sinko, Erik Hrabovszky, Balazs Gereben, Csaba Fekete
Summary: The study shows the presence of GLP-1 receptor (GLP-1R) protein and mRNA in orexigenic neuropeptide Y (NPY) neurons in the ventromedial arcuate nucleus, along with the innervation of NPY neurons by inhibitory neurons containing GLP-1R. This suggests that GLP-1 signaling can influence NPY neurons both directly and indirectly, revealing a more complex mechanism of GLP-1's effects on energy homeostasis.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Agriculture, Dairy & Animal Science
Maximiliano Muller, Elout Van Liefferinge, Marta Navarro, Elisabet Garcia-Puig, Alan Tilbrook, Robert van Barneveld, Eugeni Roura
Summary: The individual impact of the 20 proteinogenic amino acids on the secretion of anorexigenic gut hormones in pigs was studied using a small intestine ex vivo model. The results suggest that both essential and nonessential amino acids play a key role in appetite control in pigs.
JOURNAL OF ANIMAL SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Daniel I. Brierley, Guillaume de Lartigue
Summary: This review focuses on the evidence supporting the involvement of the vagus nerve in mediating the effects of peripherally and centrally produced GLP-1 on eating behavior and energy balance. Recent studies using genetic, viral, and transcriptomic approaches have provided insights into the anatomical and functional organization of GLP-1-mediated gut-brain signaling pathways, challenging traditional ideas and potentially impacting the development of pharmacological treatments for obesity.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Li Qiang, Yang Qimeng, Han Jing, Liu Xiaohan, Fu Junjie, Yin Jian
Summary: Peptide dual agonists that target both GLP-1R and GCGR receptors have emerged as potential therapeutics for treating type 2 diabetes with obesity. O-GlcNAcylation was shown to improve the stability of a dual GLP-1R/GCGR agonist, leading to significant weight loss and hypoglycemic effects.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Review
Pharmacology & Pharmacy
Baocheng Xie, Shichun Chen, Yongxiang Xu, Weichao Han, Runkai Hu, Minyi Chen, Yusheng Zhang, Shaobo Ding
Summary: Diabetes mellitus and osteoporosis are closely related, and GLP-1RAs may help in controlling blood sugar levels and promoting bone formation, but more research is needed to clarify their specific effects and mechanisms.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tiina Vesterinen, Elina Peltola, Helena Leijon, Paeivi Hannula, Heini Huhtala, Markus J. Makinen, Lasse Nieminen, Elina Pirinen, Mikko Ronty, Mirva Soderstrom, Pia Jaatinen, Johanna Arola
Summary: This study found that the lack of GLP-1R expression in insulinomas is associated with metastatic disease and impaired prognosis. GLP-1R expression could be a useful biomarker in estimating the metastatic potential and prognosis of surgically treated patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria F. Fernandes, Michelle Tomczewski, Robin E. Duncan
Summary: This study found that chronic inflammation leads to reduced GLP-1 secretion and impaired GSIS. Lysophosphatidic acids (LPAs) inhibit GLP-1 secretion in vitro and in vivo through G alpha(i)-coupled LPAR1/3 signaling, linking inflammation with impaired GSIS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Yongliang Yuan, Zhiming Yan, Qifang Lao, Neng Jiang, Shuangmin Wu, Qinpei Lu, Jing Han, Songfeng Zhao
Summary: The development of a unimolecular triple agonist peptide targeting GLP-1, glucagon, and Y2 receptors shows great potential as a novel anti-obesity and anti-diabetic agent. This peptide, 3b, demonstrated potent activity in reducing food intake without causing nausea and had better effects on lipid metabolism, body weight, and glycemic control compared to other agonist counterparts. Targeting GLP-1R, GCGR, and Y2R with a unimolecular triple agonist peptide offers a promising route for developing new treatments for obesity and T2DM.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Veterinary Sciences
Xi Chen, Xintian Nie, Huanhuan Wang, Shuping Yan, Yuanshu Zhang
Summary: Rice straw feed can promote the secretion of satiety hormones CCK and GLP-1 in sheep, reduce feed intake, and affect appetite regulation by activating specific fatty acid metabolism pathways and the receptor GPR120.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Hematology
Avital Nahmias, Priska Stahel, Lili Tian, Changting Xiao, Gary F. Lewis
Summary: The study found that GLP-1R antagonism enhances intestinal TG output in rats by stimulating lymph flow and increasing lymph TG concentration. This indicates that endogenously secreted GLP-1 after a lipid bolus is sufficient to modulate CM secretion in rats.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Wanjun Guo, Zheng Xu, Haixia Zou, Feng Li, Yao Li, Jing Feng, Zhiyi Zhu, Qing Zheng, Rui Zhu, Bin Wang, Yan Li, Sujuan Hao, Hong Qin, Catherine L. Jones, Eric Adegbite, Libnir Telusca, Martijn Fenaux, Weidong Zhong, Mohammed K. Junaidi, Susan Xu, Hai Pan
Summary: This study discovered and characterized a novel GLP-1 analog called Ecnoglutide. Through experiments and clinical trials, it was found that Ecnoglutide showed better effects in reducing blood glucose, inducing insulin, and promoting weight loss compared to semaglutide, and it demonstrated good safety and tolerability.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Xiaolong Zhang, Yuchen Cai, Zhihong Yao, Heng Chi, Yan Li, Jingjing Shi, Zhongbo Zhou, Lidan Sun
Summary: A novel GLP-1R/GCGR dual agonist, OXM-7, was discovered and shown to have potent and balanced efficacy on both receptors. In mice models, OXM-7 exhibited promising effects on glycemic control, weight loss, lipid metabolism, and hepatic steatosis reversal.
Article
Biochemistry & Molecular Biology
Adam A. Clark, Cedrick D. Dotson, Amanda E. T. Elson, Anja Voigt, Ulrich Boehm, Wolfgang Meyerhof, Nanette I. Steinle, Steven D. Munger
Review
Nutrition & Dietetics
Hillary B. Loper, Michael La Sala, Cedrick Dotson, Nanette Steinle
Article
Behavioral Sciences
Johnny A. Williams, Linda M. Bartoshuk, Roger B. Fillingim, Cedrick D. Dotson
Meeting Abstract
Biotechnology & Applied Microbiology
Sean M. Crosson, Seth Currlin, Taimoor Khan, Cedric D. Dotson, Sergei Zolotukhin
Article
Behavioral Sciences
Bronwen Martin, Cedrick D. Dotson, Yu-Kyong Shin, Sunggoan Ji, Daniel J. Drucker, Stuart Maudsley, Steven D. Munger
INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE
(2009)
Editorial Material
Behavioral Sciences
Cedrick D. Dotson
Article
Biochemistry & Molecular Biology
Amanda E. T. Elson, Cedrick D. Dotson, Josephine M. Egan, Steven D. Munger
Article
Biochemistry & Molecular Biology
Michael S. La Sala, Maria D. Hurtado, Alicia R. Brown, Diego V. Bohorquez, Rodger A. Liddle, Herbert Herzog, Sergei Zolotukhin, Cedrick D. Dotson
Article
Biochemistry & Molecular Biology
Y. -K. Shin, B. Martin, E. Golden, C. D. Dotson, S. Maudsley, W. Kim, H. -J. Jang, M. P. Mattson, D. J. Drucker, J. M. Egan, S. D. Munger
JOURNAL OF NEUROCHEMISTRY
(2008)
Article
Neurosciences
Maria D. Hurtado, Valeriy G. Sergeyev, Andres Acosta, Michael Spegele, Michael La Sala, Nickolas J. Waler, Juan Chiriboga-Hurtado, Seth W. Currlin, Herbert Herzog, Cedrick D. Dotson, Oleg S. Gorbatyuk, Sergei Zolotukhin
JOURNAL OF NEUROSCIENCE
(2013)
Article
Multidisciplinary Sciences
Cedrick D. Dotson, Lan Zhang, Hong Xu, Yu-Kyong Shin, Stephan Vigues, Sandra H. Ott, Amanda E. T. Elson, Hyun Jin Choi, Hillary Shaw, Josephine M. Egan, Braxton D. Mitchell, Xiaodong Li, Nanette I. Steinle, Steven D. Munger
Article
Behavioral Sciences
Sean M. Crosson, Andrew Marques, Peter Dib, Cedrick D. Dotson, Steven D. Munger, Sergei Zolotukhin
Article
Behavioral Sciences
Ian G. Malone, Brianna K. Hunter, Heidi L. Rossow, Herbert Herzog, Sergei Zolotukhin, Steven D. Munger, Cedrick D. Dotson
Summary: The study suggests that Y1R signaling, likely through its interactions with NPY, can modulate peripheral taste responsiveness in mice. Y1R, instead of Y2R, plays a more significant role in contributing to behavioral taste responsiveness.
HORMONES AND BEHAVIOR
(2021)
Article
Behavioral Sciences
CD Dotson, AC Spector
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)