Article
Hematology
Ramy Elsaid, Sylvain Meunier, Odile Burlen-Defranoux, Francisca Soares-da-Silva, Thibaut Perchet, Lorea Iturri, Laina Freyer, Paulo Vieira, Pablo Pereira, Rachel Golub, Antonio Bandeira, Elisa Gomez Perdiguero, Ana Cumano
Summary: During embryonic development, multiple waves of hematopoietic progenitors are regulated differently, with the first wave of thymic progenitors comprising a unique population of bipotent T and innate lymphoid cells that play a crucial role in thymic organogenesis and the establishment of the immune system.
Article
Oncology
Michael E. Todhunter, Masaru Miyano, Eric G. Carlson, Stefan Hinz, Mark A. LaBarge
Summary: A challenge in HMEC culture is maintaining the representation of different cell lineages over time. The use of postconfluent culture shows increased proportions of luminal and progenitor cells, providing a valuable tool for breast cancer research.
BREAST CANCER RESEARCH
(2023)
Article
Biology
Nadine Goldhammer, Jiyoung Kim, Rene Villadsen, Lone Ronnov-Jessen, Ole William Petersen
Summary: Single cell sequencing reveals heterogeneity in breast myoepithelial cells based on CD200 expression, with CD200-low cells exhibiting multipotency and CD200-high cells showing bipotency. This heterogeneity may have implications for the development and prevention of breast cancer.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Sirinapa Sribenja, Orla Maguire, Kristopher Attwood, Matthew F. Buas, Julie R. Palmer, Christine B. Ambrosone, Michael J. Higgins
Summary: Research suggests that not breastfeeding after childbirth increases the risk of estrogen receptor-negative breast cancer, possibly due to hypermethylation of FOXA1; moreover, it is postulated that pregnancy-associated repression of FOXA1 leads to accumulation of aberrant luminal progenitor cells, which may eventually give rise to ER- tumors.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell & Tissue Engineering
Junichi Matsuo, Naing Naing Mon, Daisuke Douchi, Akihiro Yamamura, Madhura Kulkarni, Dede Liana Heng, Sabirah Chen, Napat Nuttonmanit, Ying Li, Henry Yang, May Yin Lee, Wai Leong Tam, Motomi Osato, Linda Shyue Huey Chuang, Yoshiaki Ito
Summary: Researchers have identified an active element called eR1 that can mark mammary stem cells and found its activity in a small population of luminal epithelial cells in the mammary glands. They demonstrated that eR1+ luminal cells can generate the entire luminal lineage and milk-secreting alveoli, indicating that eR1 specifically marks lineage-restricted luminal stem cells.
Review
Oncology
Anwar Shams
Summary: In recent years, there has been increasing interest in studying the role of luminal epithelial cell lineage in breast cancer development. Myoepithelial cells have been found to play important roles in mammary gland development and in inhibiting tumorigenesis. They contribute to various processes, including maintaining the polarization of luminal cells, inhibiting cancer cell invasion, and promoting cancer cell dissemination. This review aims to investigate the role of myoepithelial cells in breast cancer progression and decipher the molecular mechanisms involved.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Pascal Peraldi, Agnes Loubat, Berengere Chignon-Sicard, Christian Dani, Annie Ladoux
Summary: Researchers identified two distinct populations of adipose progenitor cells in human breast tissue, each showing different potential and characteristics that could impact breast remodeling and cancer progression.
Article
Endocrinology & Metabolism
Nelly Saber, Cara E. E. Ellis, Diepiriye G. G. Iworima, Robert K. K. Baker, Alireza Rezania, Timothy J. J. Kieffer
Summary: This study investigates the differentiation of human embryonic stem cell-derived pancreatic endoderm cells (PECs) in different implantation sites. It is found that PECs implanted in the TheraCyte device display faster secretion of human C-peptide, while cells implanted under the kidney capsule or in the gonadal fat pad show slower secretion. Interestingly, PECs implanted under the kidney capsule in female mice exhibit faster differentiation to endocrine cells and higher levels of arginine-stimulated glucagon and glucagon-like peptide 1 secretion.
Article
Multidisciplinary Sciences
Jingyang Guan, Guan Wang, Jinlin Wang, Zhengyuan Zhang, Yao Fu, Lin Cheng, Gaofan Meng, Yulin Lyu, Jialiang Zhu, Yanqin Li, Yanglu Wang, Shijia Liuyang, Bei Liu, Zirun Yang, Huanjing He, Xinxing Zhong, Qijing Chen, Xu Zhang, Shicheng Sun, Weifeng Lai, Yan Shi, Lulu Liu, Lipeng Wang, Cheng Li, Shichun Lu, Hongkui Deng
Summary: This study demonstrates the chemical reprogramming of human somatic cells to human chemically induced pluripotent stem cells, which exhibit key features of embryonic stem cells. The induction of an intermediate plastic state and inhibition of the JNK pathway are crucial for successful chemical reprogramming.
Article
Multidisciplinary Sciences
Tapsi Kumar, Kevin Nee, Runmin Wei, Siyuan He, Quy H. Nguyen, Shanshan Bai, Kerrigan Blake, Maren Pein, Yanwen Gong, Emi Sei, Min Hu, Anna K. Casasent, Aatish Thennavan, Jianzhuo Li, Tuan Tran, Ken Chen, Benedikt Nilges, Nachiket Kashikar, Oliver Braubach, Bassem Ben Cheikh, Nadya Nikulina, Hui Chen, Mediget Teshome, Brian Menegaz, Huma Javaid, Chandandeep Nagi, Jessica Montalvan, Tatyana Lev, Sharmila Mallya, Delia F. Tifrea, Robert Edwards, Erin Lin, Ritesh Parajuli, Summer Hanson, Sebastian Winocour, Alastair Thompson, Bora Lim, Devon A. Lawson, Kai Kessenbrock, Nicholas Navin
Summary: By studying the adult human breast tissue at a single-cell and spatial level, we constructed a comprehensive Human Breast Cell Atlas, identifying 12 major cell types and 58 biological cell states. Our findings reveal a rich ecosystem of tissue-resident immune cells, as well as molecular differences between ductal and lobular regions. These data serve as a reference for studying mammary biology and diseases like breast cancer.
Article
Genetics & Heredity
Kevin Nee, Dennis Ma, Quy H. Nguyen, Maren Pein, Nicholas Pervolarakis, Jacob Insua-Rodriguez, Yanwen Gong, Grace Hernandez, Hamad Alshetaiwi, Justice Williams, Maha Rauf, Kushal Rajiv Dave, Keerti Boyapati, Aliza Hasnain, Christian Calderon, Anush Markaryan, Robert Edwards, Erin Lin, Ritesh Parajuli, Peijie Zhou, Qing Nie, Sundus Shalabi, Mark A. LaBarge, Kai Kessenbrock
Summary: Premalignant stromal cells from women with germline BRCA1 mutations have increased expression of secreted factors regulating epithelial homeostasis, promoting premalignant epithelial changes and increased breast cancer risk. The stromal niche in BRCA1-driven tumor initiation promotes epithelial proliferation and mutant BRCA1-driven tumorigenesis through paracrine signals, such as matrix metalloproteinase 3 (MMP3), produced by pre-cancer-associated fibroblasts (pre-CAFs). This study highlights the importance of precancerous stroma in BRCA1(+/mut) in elevating breast cancer risk.
Article
Cell Biology
Guojuan Jiang, Juchuanli Tu, Lei Zhou, Mengxue Dong, Jue Fan, Zhaoxia Chang, Lixing Zhang, Xiuwu Bian, Suling Liu
Summary: The study constructed a single-cell atlas of tumor progression stages in a breast cancer mouse model, revealing the role of ERlow epithelial cell lineage in tumor initiation and the blockade of differentiation in ERhigh epithelial cell lineage. Furthermore, a stem-like cell cluster was identified within ERlow epithelial cells, showing heterogeneity. This study also highlighted the dynamics of immune cell infiltration and the potential cross-talk between BCSCs and immune cells during breast tumor progression.
CELL DEATH & DISEASE
(2021)
Article
Endocrinology & Metabolism
Roni H. G. Wright, Viviana Vastolo, Javier Quilez Oliete, Jose Carbonell-Caballero, Miguel Beato
Summary: This study used antibody microarrays and phosphoproteomics to investigate the signaling pathways involved in breast cancer cell proliferation following progestin exposure. Through detailed analysis, new key proteins, phosphorylation sites, and signaling pathways were identified, shedding light on the mechanisms underlying cell cycle regulation in breast cancer cells. The study also revealed changes in protein complexes involved in nuclear structure and epithelial to mesenchyme transition. This research provides valuable insights for understanding breast cancer biology and may have implications for cancer management.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Sarit Cohen-Kedar, Efrat Shaham Barda, Keren Masha Rabinowitz, Danielle Keizer, Hanan Abu-Taha, Shoshana Schwartz, Kawsar Kaboub, Liran Baram, Eran Sadot, Ian White, Nir Wasserberg, Meirav Wolff-Bar, Adva Levy-Barda, Iris Dotan
Summary: This study discovered that human intestinal epithelial cells can phagocytose fungal particles containing beta-glucan through autophagy-associated processes. This mechanism contributes to the maintenance of mucosal tolerance towards commensal fungi.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Laetitia Delort, Juliette Cholet, Caroline Decombat, Marion Vermerie, Charles Dumontet, Florence A. Castelli, Francois Fenaille, Celine Auxenfans, Adrien Rossary, Florence Caldefie-Chezet
Summary: Breast cancer is the most common cancer among women worldwide, with overweight and obesity recognized as established risk factors. The adipose microenvironment can influence the functionality of myoepithelial cells, potentially promoting the transition from in situ to invasive carcinoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Pratima Basak, Sumanta Chatterjee, Steven Weger, M. Christine Bruce, Leigh C. Murphy, Afshin Raouf
ENDOCRINE-RELATED CANCER
(2015)
Article
Surgery
Sumanta Chatterjee, Mike Laliberte, Sarah Blelloch, Imran Ratanshi, Janice Safneck, Ed Buchel, Afshin Raouf
PLASTIC AND RECONSTRUCTIVE SURGERY
(2015)
Editorial Material
Biotechnology & Applied Microbiology
Kallesh D. Jayappa, Ramesh C. Kovi, Sumanta Chatterjee
BIOMED RESEARCH INTERNATIONAL
(2016)
Article
Cell & Tissue Engineering
Sumanta Chatterjee, Pratima Basak, Edward Buchel, Janice Safneck, Leigh C. Murphy, Michael Mowat, Sam K. Kung, Peter Eirew, Connie J. Eaves, Afshin Raouf
Article
Environmental Sciences
Sumanta Chatterjee, Pratima Basak, Malay Chaklader, Prosun Das, Jacintha Archana Pereira, Samaresh Chaudhuri, Sujata Law
ENVIRONMENTAL TOXICOLOGY
(2014)
Article
Pathology
Sumanta Chatterjee, Pratima Basak, Malay Chaklader, Prosun Das, Jacintha Archana Pereira, Samaresh Chaudhuri, Sujata Law
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
(2013)
Article
Multidisciplinary Sciences
Sumanta Chatterjee, Stephanie Bacopulos, Wenyi Yang, Yutaka Amemiya, Demetri Spyropoulos, Afshin Raouf, Arun Seth
Review
Cell & Tissue Engineering
Pratima Basak, Sumanta Chatterjee, Madhurima Das, Prosun Das, Jacintha Archana Pereira, Ranjan Kumar Dutta, Malay Chaklader, Samaresh Chaudhuri, Sujata Law
CURRENT STEM CELL RESEARCH & THERAPY
(2010)
Article
Cell & Tissue Engineering
Sumanta Chatterjee, Pratima Basak, Edward Buchel, Leigh C. Murphy, Afshin Raouf
STEM CELL RESEARCH & THERAPY
(2018)
Article
Oncology
Alberto Servetto, Rahul Kollipara, Luigi Formisano, Chang-Ching Lin, Kyung-Min Lee, Dhivya R. Sudhan, Paula I. Gonzalez-Ericsson, Sumanta Chatterjee, Angel Guerrero-Zotano, Saurabh Mendiratta, Hiroaki Akamatsu, Nicholas James, Roberto Bianco, Ariella B. Hanker, Ralf Kittler, Carlos L. Arteaga
Summary: FGFR1 overexpression in the nucleus of breast cancer cells is associated with endocrine resistance in ER+ breast cancer. Nuclear FGFR1 influences gene transcription and promotes resistance to estrogen suppression and fulvestrant. Treatment with FGFR tyrosine kinase inhibitors does not affect nuclear FGFR1 activity, supporting the development of strategies to inhibit nuclear FGFR1 in ER+/FGFR1 overexpressing breast cancer.
CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Sumanta Chatterjee, Vasudeva Bhat, Alexei Berdnikov, Jiahui Liu, Guihua Zhang, Edward Buchel, Janice Safneck, Aaron J. Marshall, Leigh C. Murphy, Lynne-Marie Postovit, Afshin Raoufl
Article
Cell Biology
Pratima Basak, Sumanta Chatterjee, Vasudeva Bhat, Alice Su, Hyerang Jin, Victoria Lee-Wing, Qian Liu, Pingzhao Hu, Leigh C. Murphy, Afshin Raouf
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Cell & Tissue Engineering
Sumanta Chatterjee, Pratima Basak, Prosun Das, Madhurima Das, Jacintha Archana Pereira, Ranjan Kumar Dutta, Malay Chaklader, Samaresh Chaudhuri, Sujata Law
STEM CELLS INTERNATIONAL
(2010)
Article
Cell & Tissue Engineering
Sumanta Chatterjee, Ranjan Kumar Dutta, Pratima Basak, Prosun Das, Madhurima Das, Jacintha Archana Pereira, Malay Chaklader, Samaresh Chaudhuri, Sujata Law
STEM CELLS INTERNATIONAL
(2010)
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
