Article
Cell Biology
Ofer Shoshani, Bjorn Bakker, Lauren de Haan, Andrea E. Tijhuis, Yin Wang, Dong Hyun Kim, Marcus Maldonado, Matthew A. Demarest, Jon Artates, Ouyang Zhengyu, Adam Mark, Rene Wardenaar, Roman Sasik, Diana C. J. Spierings, Benjamin Vitre, Kathleen Fisch, Floris Foijer, Don W. Cleveland
Summary: Abnormal numerical and structural chromosome content is often observed in human cancers. A study in mice showed that transient induction of aneuploidy can lead to the formation of cancer with specific karyotype profiles, demonstrating that distinct mechanisms of chromosome instability can result in similar cancer-causing outcomes.
GENES & DEVELOPMENT
(2021)
Article
Cell Biology
Yan Gong, Shitian Zou, Daizhao Deng, Liang Wang, Hongling Hu, Zeyou Qiu, Tiantian Wei, Panpan Yang, Jielong Zhou, Yu Zhang, Weiliang Zhu, Xiaoling Xie, Zhengquan Liao, Jun Yang, Sheng Zhang, Anling Liu, Yu Jiang, Zhipeng Zou, Xiaochun Bai
Summary: Chromothripsis is a catastrophic event of chromosomal instability characterized by extensive fragmentation and rearrangements within localized chromosomal regions. RanGAP1 deficiency is commonly observed in human osteosarcoma and is associated with a high rate of chromothripsis. Loss of RanGAP1 leads to chromosomal instability and tumorigenesis through its effects on spindle assembly checkpoint (SAC), chromatid decatenation and DNA damage surveillance.
DEVELOPMENTAL CELL
(2023)
Review
Biochemistry & Molecular Biology
Dario Rizzotto, Lukas Englmaier, Andreas Villunger
Summary: P53 is a critical tumor suppressor that prevents oncogenesis through multiple pathways, leading to cell cycle arrest and cell death. Its function is cell-type and stimulus-specific, ultimately imposing a barrier to cellular transformation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jinfeng Jiang, Tong Qiu, Chao Yang, Yuan Yuan, Ling Qin, Peixuan Zhang
Summary: The short G1 phase of embryonic stem cells results from the promotion of G1/S transition by MEK1/2 kinases, but it is not necessarily related to pluripotency maintenance. Inhibition of MEK1/2 kinases in naive ESCs leads to a longer G1 phase. This inhibition increases the level of reactive oxygen species (ROS) and stabilizes the p53 protein. The genetic ablation of p53 transforms the cell cycle profile of naive ESCs to that of primed ESCs.
Article
Biochemistry & Molecular Biology
Huan Liu, Wenchao Zhang, Lijie Jin, Shasha Liu, Liying Liang, Yanfei Wei
Summary: This study investigates the anticancer mechanism of Plumbagin (PLB) and its potential connections with oxidative stress, genotoxicity, and cell cycle arrest. The results indicate that PLB significantly inhibits HCC cell viability and colony formation, induces G2/M cell cycle arrest, oxidative stress, and DNA damage. These effects can be attenuated by NAC pretreatment. PLB triggers a DNA damage response by activating ATM, Chk1, Chk2, and p53. Furthermore, the key modulator of the G2/M transition factor, cdc25C, is downregulated in an ROS-dependent manner. Inhibition of the ATM-p53 pathway can reduce the occurrence of G2/M cell cycle arrest. Therefore, ROS-mediated oxidative stress plays a crucial role in PLB-induced G2/M cell cycle arrest mediated by the ATM-p53 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yixuan Wang, Yuntao Li, Qian Sun, Fanen Yuan, Yang Xu, Shiao Tong, Yong Li, Shangfeng Yi, Tengfeng Yan, Qianxue Chen, Baohui Liu
Summary: The study indicates that BCAS3 is up-regulated in GBM, and its high expression predicts poor prognosis. BCAS3 significantly regulates GBM cell proliferation and cell cycle, and is associated with the p53/GADD45α pathway.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Virology
Zhuofan Deng, Renjie Sun, Xiao Han, Yikai Zhang, Yingshan Zhou, Ying Shan, Jidong Xu, Xiaoliang Li, Fang He, Weihuan Fang
Summary: Coinfections or noninfectious triggers are known to potentiate PCV2 infection, resulting in PCVAD. However, the mechanisms involved remain largely unknown. This study reveals that PCV2 activates the PERK-ROS-p53 nexus to induce cell cycle arrest at the S phase, promoting viral replication. These findings provide novel insights into the manipulation of host cell responses by PCV2.
JOURNAL OF VIROLOGY
(2022)
Article
Oncology
Laura C. Funk, Jun Wan, Sean D. Ryan, Charanjeet Kaur, Ruth Sullivan, Avtar Roopra, Beth A. Weaver
Summary: Chromosomal instability is a hallmark of cancer, with high levels of CIN causing cell death and tumor suppression. The tumor suppressor p53 is not required for high CIN-induced tumor suppression, as demonstrated by pharmacological induction of high CIN resulting in cell death independently of p53 function.
MOLECULAR CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Essam H. Ibrahim, Mohammad Y. Alshahrani, Hamed A. Ghramh, Hani Alothaid, Mona Kilany, Kareem Morsy, Attalla F. El-kott, Ramadan Taha, Haitham El-Mekkawy, Gamal A. EL-Shaboury, Ahmed A. El-Mansi, Mohammed E. A. Mohammed, Mahmoud A. Sayed, Ibrahim S. Yahia
Summary: The study demonstrates that Origanum majorana leaf acetone extract has anti-colorectal cancer effects by inducing cell division arrest and apoptosis in HT-29 human colon cancer cells.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
ElHusseiny M. M. Abdelwahab, Judit Bovari-Biri, Gabor Smuk, Janos Fillinger, Donald McPhail, Vera P. Krymskaya, Judit E. Pongracz
Summary: This study investigates the deregulation of cell death processes in TSC mutation, and identifies a potential treatment strategy involving the use of Proxison and rapamycin in combination to increase ROS production, modify miRNA expression pattern, and reduce cell viability.
Article
Oncology
Lilia Gheghiani, Lei Wang, Youwei Zhang, Xavier T. R. Moore, Jinglei Zhang, Steven C. Smith, Yijun Tian, Liang Wang, Kristi Turner, Colleen K. Jackson-Cook, Nitai D. Mukhopadhyay, Zheng Fu
Summary: Overexpression of Plk1 drives tumorigenesis by causing chromosomal instability and aneuploidy, and higher expression of PLK1 is associated with increased genome-wide copy-number alterations in multiple human cancers. These findings suggest potential therapeutic opportunities for CIN-positive cancers.
Article
Cell Biology
Wunan Mi, Chuyue Wang, Guang Luo, Jiehan Li, Yizheng Zhang, Meimei Jiang, Chuchu Zhang, Nannan Liu, Xinxiu Jiang, Ge Yang, Lingling Zhang, Ge Zhang, Yingjie Zhang, Yang Fu
Summary: This study demonstrates that CC90003 induces autophagy by activating ROS/p53, leading to cell death in colorectal cancer. Combination treatment with CC90003 plus CQ shows significant efficacy in the xenograft mouse model, providing new potential targets for clinical therapy.
CELL DEATH DISCOVERY
(2021)
Article
Gastroenterology & Hepatology
Xudan Wang, Yang Wang, Long Yang, Juzheng Yuan, Weiwei Shen, Wenjie Zhang, Jianlin Wang, Kaishan Tao
Summary: ASRGL1 is highly expressed in hepatocellular carcinoma (HCC) and is associated with poor overall survival. Knockdown of ASRGL1 inhibits cell proliferation, migration, and invasion, and promotes apoptosis in HCC cells. ASRGL1 may be involved in the regulation of the cell cycle in HCC. These findings demonstrate that ASRGL1 blockade functions through cell cycle inhibition to suppress tumor growth in HCC.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Fabin Dang, Li Nie, Wenyi Wei
Summary: Cell cycle progression relies on the activation of cyclin-dependent kinases, regulated in part by ubiquitin-mediated proteolysis. Dysregulated proteolytic control can lead to uncontrolled cell proliferation and tumorigenesis. Targeting E3 ubiquitin ligases involved in cell cycle regulation may offer novel therapeutic strategies for cancer treatment.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Toxicology
Hardeep Singh Tuli, Jagjit Kaur, Kanupriya Vashishth, Katrin Sak, Ujjawal Sharma, Renuka Choudhary, Tapan Behl, Tejveer Singh, Sheetu Sharma, Adesh K. Saini, Kuldeep Dhama, Mehmet Varol, Gautam Sethi
Summary: ROS plays important roles in living organisms, with moderate levels affecting disease development and excessive levels leading to cell death. Current research is focused on using chemotherapy drugs and herbal agents to induce cancer cell death, while maintaining ROS homeostasis is crucial for cell development and survival.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)