期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 22, 期 8, 页码 806-815出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.08.010
关键词
Saccharomyces cerevisiae; Candida albicans; Hyphal growth; Symmetry breaking; Fungi
资金
- Centre National de la Recherche Scientifique
- Agence Nationale pour la Recherche
- Association pour la Recherche sur le Cancer
Cell shape is a critical determinant for function. The baker's yeast Saccharomyces cerevisiae changes shape in response to its environment, growing by budding in rich nutrients, forming invasive pseudohyphal filaments in nutrient poor conditions and pear shaped shmoos for growth towards a partner during mating. The human opportunistic pathogen Candida albicans can switch from budding to hyphal growth, in response to numerous environmental stimuli to colonize and invade its host. Hyphal growth, typical of filamentous fungi, is not observed in S. cerevisiae. A number of internal cues regulate when and where yeast cells break symmetry leading to polarized growth and ultimately distinct cell shapes. This review discusses how cells break symmetry using the yeast S. cerevisiae paradigm and how polarized growth is initiated and maintained to result in dramatic morphological changes during C. albicans hyphal growth. (C) 2011 Elsevier Ltd. All rights reserved.
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