Review
Plant Sciences
Lu Xiong, Wenguan Zhou, Paloma Mas
Summary: The circadian clock and light signaling pathways are closely interconnected, and chromatin remodeling plays a crucial role in regulating transcription timing and light-dependent responses.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Article
Plant Sciences
Chae Jin Lim, Ki Suk Park, Akhtar Ali, Junghoon Park, Seung Min Ryou, Mingzhe Shen, Haris Ali Khan, Zein Eddin Bader, Shah Zareen, Min Jae Bae, Jong Hyoo Choi, Zheng-Yi Xu, Jose M. Pardo, Dae-Jin Yun
Summary: The Arabidopsis HOS15/PWR/HDA9 repressor complex negatively regulates flowering time by deacetylating the AGL19 promoter, leading to early flowering.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Plant Sciences
Luis Cervela-Cardona, Benjamin Alary, Paloma Mas
Summary: A fundamental principle shared by all organisms is the conversion of nutrients into energy, requiring precise spatiotemporal programming. Cellular metabolism can adapt to external time, relying on the circadian clock. The circadian clock plays a prevalent role in controlling the timing of mitochondrial activity and cellular energy in Arabidopsis thaliana, with evidence showing metabolic signals can feedback to the clock.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Takahiro N. Uehara, Saori Takao, Hiromi Matsuo, Ami N. Saito, Eisuke Ota, Azusa Ono, Kenichiro Itami, Toshinori Kinoshita, Takafumi Yamashino, Junichiro Yamaguchi, Norihito Nakamichi
Summary: A novel synthetic small molecule called TU-892 has been found to affect the amount of PRR7 protein, leading to lengthening of the circadian clock period in plants. The study showed that TU-892 treatment upregulates the expression of CCA1 gene and reduces the amount of PRR7 protein. This novel clock modulator provides new tools and avenues for studying the circadian clock in plants.
PLANT AND CELL PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Honglv Jiang, Xiaohui Wang, Jingjing Ma, Guoqiang Xu
Summary: Circadian rhythm is a 24-hour cycle that regulates biological functions and activities in organisms. The circadian clock is controlled by a feedback loop involving core clock proteins and accessory factors. Recent research reveals that CLOCK exhibits lysine acetyltransferase activities, impacting the biological functions of core clock proteins and downstream gene expression. This review explores the role of acetylation in circadian rhythm and discusses the interactions between lysine acetylation and other posttranslational modifications.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Article
Plant Sciences
Hikari Ikeda, Taiga Uchikawa, Yohei Kondo, Nozomu Takahashi, Takuma Shishikui, Masaaki K. Watahiki, Akane Kubota, Motomu Endo
Summary: Plants adapt to environmental changes through circadian clocks, and this study found that root hair elongation in Arabidopsis is controlled by both light and the circadian clock. Genes encoding major components of the central oscillator regulate the rhythmicity of root hair length. Grafting experiments showed that TOC1 in shoots is responsible for the generation of root hair rhythmicity.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Hong-Sheng Liao, Chien-Chih Yang, Ming-Hsiun Hsieh
Summary: The study reveals that HDA15-mediated histone modification regulates anthocyanin accumulation in response to N deficiency and other stresses in Arabidopsis. Different stresses activate anthocyanin biosynthesis through distinct regulatory modules.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Review
Plant Sciences
Nobutoshi Yamaguchi
Summary: Certain eukaryotic transcription factors have the ability to reprogram one cell type into another, with pioneer factors being able to engage target sites in closed chromatin. In plants, the TF LEAFY acts as a pioneer factor specifying floral fate and interacts with other factors to regulate floral development.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Takahiro N. Uehara, Takashi Nonoyama, Kyomi Taki, Keiko Kuwata, Ayato Sato, Kazuhiro J. Fujimoto, Tsuyoshi Hirota, Hiromi Matsuo, Akari E. Maeda, Azusa Ono, Tomoaki T. Takahara, Hiroki Tsutsui, Takamasa Suzuki, Takeshi Yanai, Steve A. Kay, Kenichiro Itami, Toshinori Kinoshita, Junichiro Yamaguchi, Norihito Nakamichi
Summary: This study demonstrates the necessity of CDKC;2 in maintaining the circadian period in Arabidopsis. Through chemical biology and genetic approaches, it was found that CDKC;2 maintains transcriptional activity by phosphorylating the C-terminal domain of RNA polymerase II, affecting clock gene expression and period length.
PLANT AND CELL PHYSIOLOGY
(2022)
Article
Plant Sciences
Luis Cervela-Cardona, Takuya Yoshida, Youjun Zhang, Masaaki Okada, Alisdair Fernie, Paloma Mas
Summary: The Arabidopsis clock component TOC1 plays a crucial role in the diurnal regulation of metabolism by repressing the expression of the TCA-related gene FUMARASE 2 at night. This regulation affects the accumulation of fumarate and contributes to the molecular and physiological energy-deprivation phenotypes of TOC1 over-expressing plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Genetics & Heredity
Yongtao Han, Amira Haouel, Elisabeth Georgii, Santiago Priego-Cubero, Christoph J. Wurm, Daniel Hemmler, Philippe Schmitt-Kopplin, Claude Becker, Joerg Durner, Christian Lindermayr
Summary: Histone deacetylation by HD2A and HD2B regulates gene expression and ABA biosynthesis, leading to enhanced drought resistance in Arabidopsis. The hd2ahd2b mutant displays hypersensitivity to exogenous ABA and shows upregulation of ABA-responsive genes and H4K5ac levels. HD2A/HD2B directly bind to specific ABA-responsive genes and repress ABA biosynthesis by deacetylating H4K5ac at NCED9. These findings highlight the important role of HD2A and HD2B in ABA signaling and their negative regulation in drought resistance.
Article
Biochemistry & Molecular Biology
Junyan Xie, Lihua Wang, Huiqiong Zheng
Summary: Understanding how spaceflight affects plant flowering is crucial for long-term human space exploration. Recent space experiments showed that flowering initiation in plants was delayed by about 20 days in space compared to the control group on the ground, and gene expression levels were altered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Ami N. Saito, Akari E. Maeda, Tomoaki T. Takahara, Hiromi Matsuo, Michiya Nishina, Azusa Ono, Katsuhiro Shiratake, Michitaka Notaguchi, Takeshi Yanai, Toshinori Kinoshita, Eisuke Ota, Kazuhiro J. Fujimoto, Junichiro Yamaguchi, Norihito Nakamichi
Summary: The circadian clock, an internal time-keeping system, coordinates physiological processes. BML-259, a small molecule with CDK5/CDK2 inhibition activity, lengthens Arabidopsis circadian clock periods.
PLANT AND CELL PHYSIOLOGY
(2022)
Article
Biology
Suil Kim, Douglas G. McMahon
Summary: This study reveals that light input to the SCN can change the waveform of molecular clockworks, marking clock advances and delays at simulated dawn and dusk. The changes in waveform seem to be greatest in the ventrolateral SCN, while the effects on period are greatest in the dorsomedial SCN, suggesting spatiotemporally distinct responses within the SCN neural network.
Article
Plant Sciences
Simon Obermeyer, Richard Stoeckl, Tobias Schnekenburger, Christoph Moehle, Uwe Schwartz, Klaus D. Grasser
Summary: Transcript elongation by RNA polymerase II (RNAPII) plays a significant role in plant development and response to environmental cues. The heterohexameric polymerase-associated factor 1 complex (PAF1C) stabilizes RNAPII elongation complex and promotes efficient transcript synthesis. This study reveals distinct transcriptional responses of PAF1C subunit mutants ELF7 and CDC73 to high salt exposure, suggesting their (partial) specific functions.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Environmental Sciences
Lucas G. Sosa Alderete, Mario E. Guido, Elizabeth Agostini, Paloma Mas
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2018)
Article
Cell Biology
Magdalena Woloszynska, Olimpia Gagliardi, Filip Vandenbussche, Steven De Groeve, Luis Alonso Baez, Pia Neyt, Sabine Le Gall, Jorge Fung, Paloma Mas, Dominique Van Der Straeten, Mieke Van Lijsebettens
JOURNAL OF CELL SCIENCE
(2018)
Article
Multidisciplinary Sciences
Cristina Izquierdo, Angela Zarama Ortiz, Maximiliano Presa, Sara Malo, Anna Montoya, Nahir Garabatos, Conchi Mora, Joan Verdaguer, Thomas Stratmann
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Marta Sistere-Oro, Julia Vergara-Alert, Thomas Stratmann, Sergi Lopez-Serrano, Sonia Pina-Pedrero, Lorena Cordoba, Monica Perez-Maillo, Patricia Pleguezuelos, Enric Vidal, Veljko Veljkovic, Joaquim Segales, Jens Nielsen, Anders Fomsgaard, Ayub Darji
Article
Multidisciplinary Sciences
Magdalena Woloszynska, Sabine Le Gall, Pia Neyt, Tommaso M. Boccardi, Marion Grasser, Gernot Laengst, Stijn Aesaert, Griet Coussens, Stijn Dhondt, Eveline Van De Slijke, Leonardo Bruno, Jorge Fung-Uceda, Paloma Mas, Marc Van Montagu, Dirk Inze, Kristiina Himanen, Geert De Jaeger, Klaus D. Grasser, Mieke Van Lijsebettens
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Immunology
Leire Egia-Mendikute, Berta Arpa, Estela Rosell-Mases, Marta Corral-Pujol, Jorge Carrascal, Jorge Carrillo, Conchi Mora, Harold Chapman, Anais Panosa, Marta Vives-Pi, Thomas Stratmann, David Serreze, Joan Verdaguer
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Plant Sciences
Meixuezi Tong, Kyounghee Lee, Daphne Ezer, Sandra Cortijo, Jaehoon Jung, Varodom Charoensawan, Mathew S. Box, Katja E. Jaeger, Nozomu Takahashi, Paloma Mas, Philip A. Wigge, Pil Joon Seo
Article
Oncology
Jose M. Carbo, Theresa E. Leon, Joan Font-Diaz, Juan Vladimir De la Rosa, Antonio Castrillo, Felix R. Picard, Daniel Staudenraus, Magdalena Huber, Lidia Cedo, Joan Carles Escola-Gil, Lucia Campos, Latifa Bakiri, Erwin F. Wagner, Carme Caelles, Thomas Stratmann, Jo A. Van Ginderachter, Annabel F. Valledor
Summary: The study demonstrated that synthetic LXR agonist TO901317 inhibits tumor growth in a murine model of Lewis lung carcinoma, with antitumor effects reliant on functional LXR activity in host cells. By reducing the abundance and expression of certain factors in Tregs and TAMs, the LXR pathway exerts a comprehensive control over TAM responses in the tumor microenvironment.
Article
Immunology
Ester Sala, Celia Vived, Julia Luna, Noemi Alejandra Saavedra-Avila, Upasana Sengupta, A. Raul Castano, Sabrina Villar-Pazos, Laura Haba, Joan Verdaguer, Ana B. Ropero, Thomas Stratmann, Javier Pizarro, Manuel Vazquez-Carrera, Angel Nadal, Jill M. Lahti, Conchi Mora
Summary: CDK11 downregulation in T1D acts as a protective mechanism against inflammation-induced apoptosis, and it may regulate Cyclin D3 signaling.
CDK11 hemideficiency protects against T1D progression and affects pancreatic islet sensitivity to cytokine-induced apoptosis.
CDK11/Cyclin D3 tandem could be a potential new intervention target in T1D.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Plant Sciences
Lu Xiong, Wenguan Zhou, Paloma Mas
Summary: The circadian clock and light signaling pathways are closely interconnected, and chromatin remodeling plays a crucial role in regulating transcription timing and light-dependent responses.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Article
Cell Biology
Masaaki Okada, Zhiyuan Yang, Paloma Mas
Summary: This study identified the circadian components and transcriptional networks involved in generating rhythms in pistils. It revealed that pistils have organ-specific circadian autonomy and that clock activators and repressors have distinct expression patterns and regulatory functions. Genetic interaction studies also showed a hierarchy of repressing activities that contribute to the robustness and precision of the pistil clock. Additionally, the study found that circadian function in pistils primarily governs responses to environmental stimuli and photosynthesis, and controls pistil growth and seed production.
DEVELOPMENTAL CELL
(2022)
Article
Plant Sciences
Wei Wei Chen, Nozomu Takahash, Yoshito Hirata, James Ronald, Silvana Porco, Seth J. Davis, Dmitri A. Nusinow, Steve A. Kay, Paloma Mas
Article
Biotechnology & Applied Microbiology
Qingxin Song, Tien-Yu Huang, Helen H. Yu, Atsumi Ando, Paloma Mas, Misook Ha, Z. Jeffrey Chen
Article
Biology
Kyounghee Lee, Paloma Mas, Pil Joon Seo
COMMUNICATIONS BIOLOGY
(2019)
Review
Biotechnology & Applied Microbiology
Z. Jeffrey Chen, Paloma Mas
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)