Article
Medicine, Research & Experimental
Diane Bruyere, Patrick Roncarati, Alizee Lebeau, Thomas Lerho, Florian Poulain, Elodie Hendrick, Charlotte Pilard, Celia Reynders, Marie Ancion, Margaux Luyckx, Michael Renard, Yves Jacob, Jean-Claude Twizere, Raphael Peiffer, Olivier Peulen, Philippe Delvenne, Pascale Hubert, Alison McBride, Nicolas Gillet, Murielle Masson, Michael Herfs
Summary: HPV-positive cancers are usually associated with a favorable outcome due to high sensitivity to radiation therapy. However, the impact of viral E6/E7 oncoproteins on cellular radiosensitivity and host DNA repair is still largely speculative.
Article
Virology
Kerry Dust, Michael Carpenter, Julie Chih-yu Chen, Chris Grant, Stuart McCorrister, Garret R. Westmacott, Alberto Severini
Summary: This study investigates the effects of HPV16 viral proteins E6 and E7 on the host proteome in human neonatal keratinocytes. The results show that the expression of E6 and E7 leads to dysregulation in pathways related to interferon response, inflammation, and DNA damage repair. The study also identifies potential biomarkers associated with HPV oncoproteins in primary keratinocytes.
Review
Biochemistry & Molecular Biology
RamaRao Malla, Mohammad Amjad Kamal
Summary: Cervical cancer is the fourth leading cancer in women aged 15-44 globally, primarily caused by HPV16 and 18. The oncoproteins E6 and E7, key players in cervical cancer, can affect the cell cycle and interfere with the normal functions of host cells.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Diego Carrillo-Beltran, Julio C. Osorio, Rances Blanco, Carolina Oliva, Enrique Boccardo, Francisco Aguayo
Summary: Although epidemiological studies suggest that tobacco smoking and HR-HPV infection are mutually exclusive risk factors for developing HNC, some individuals are both HPV-positive and smokers. Both factors increase oxidative stress and DNA damage. This study found that oral cells expressing HPV16 E6/E7 oncoproteins exposed to cigarette smoke condensate showed synergistic increases in SOD2 levels and DNA damage, independent of Akt1 and ATM. These findings suggest that the interaction between HPV and cigarette smoke in HNC promotes SOD2 alterations, leading to increased DNA damage and the development of a distinct clinical entity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Sadhana M. Gupta, Himangi Warke, Hemangi Chaudhari, Padmaja Mavani, Rajshree D. Katke, Shilpa C. Kerkar, Jayanti Mania-Pramanik
Summary: This study aimed to evaluate HPV E6/E7 oncogene expression as markers for early identification of cervical cancer risk in women with minor cytological abnormalities and negative cytology. The results showed that E6 and E7 transcripts could serve as sensitive early predictors of cervical cancer risk.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Oncology
Francesca Paolini, Carla Amici, Mariantonia Carosi, Claudia Bonomo, Paola Di Bonito, Aldo Venuti, Luisa Accardi
Summary: The study revealed that scFvs targeting HPV16 E6 and E7 proteins were effective in delaying tumor progression in experimental models, and their antitumor activity appeared to be based on driving tumor cells towards the apoptotic pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Soyeong Park, Andrew Auyeung, Denis L. Lee, Paul F. Lambert, Evie H. Carchman, Nathan M. Sherer
Summary: High-risk strains of human papillomavirus (HPV), such as HPV16, cause various cancers, including cervical cancer, which is a major cause of death for women globally. Anti-HPV vaccines are available but do not treat existing infections. Current treatments for HPV-associated cancers have side effects on healthy tissues, prompting the need for better targeted therapies. The study found that HIV protease inhibitors can selectively deplete HPV16 oncoproteins, suggesting their potential for treating HPV16-driven cancers.
Article
Multidisciplinary Sciences
D. S. Prabakaran, Pankaj Kumar Chaturvedi, Dineshkumar Krishnamoorthy, Young-Seok Seo, Mallikarjuna Thippana, Woo-Yoon Park
Summary: This study investigated the relationship between fused toes homolog (FTS) and HPV16 E6 and E7 in cervical cancer cells. The results showed that silencing FTS reduced the expression of E6 and E7 proteins, and promoted the expression of tumor suppressors. Immunanalysis demonstrated the interaction and co-localization of FTS with E6 and E7 proteins.
Article
Biochemistry & Molecular Biology
Elvin Peter Chizenga, Heidi Abrahamse
Summary: Immunogenic proteins in cancer can be targeted for drug delivery. In this study, a compound was used to specifically recognize and bind to intracellular E6 oncoproteins in HPV-transformed cancer cells, enhancing both cellular uptake and retention of the photosensitizer. This provides insight into preventing cell-mediated resistance to Photodynamic Therapy (PDT).
Article
Virology
Shuo Li, Mengxia Ye, Yonglin Chen, Quan Gong, Bing Mei
Summary: This study sheds light on the relationship between HPV-52 and cervical cancer, identifying variations in the E6-E7 genes and analyzing the protein's structure and selective pressure. Multiple single nucleotide variants were found in the E6 and E7 sequences of HPV-52, some impacting B cell epitopes.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Ayazhan Akhatova, Chee Kai Chan, Azliyati Azizan, Gulzhanat Aimagambetova
Summary: Cervical cancer is a serious public health concern, and despite existing preventative and screening methods, it remains a common and deadly cancer. DNA therapeutic vaccines show promise in treating cervical cancer, with their safety and effectiveness being well-documented.
Review
Virology
James C. Romero-Masters, Paul F. Lambert, Karl Munger
Summary: HPVs cause a wide range of human diseases, from benign warts to malignant cancers. The discovery of a murine papillomavirus that infects laboratory mice provides an opportunity to study HPV-induced malignant diseases. The E6 and E7 proteins encoded by high-risk HPVs contribute to HPV-induced cancers in multiple ways.
Article
Virology
Mengxia Ye, Shuo Li, Ping Luo, Xuan Tang, Quan Gong, Bing Mei
Summary: This study analyzed the variations and phylogenetic relationship of HPV-51 virus in central China, as well as predicted its immune epitopes. The results showed high prevalence and genetic variations of HPV-51 in the region. These findings are of great importance for future research on vaccines with wider coverage and the development of diagnostic probes.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leonardo Trujillo-Cirilo, Edgar Ivan Torres-Corioriles, Rosalva Rangel-Corona, Maria Teresa Corona-Ortega, Benny Weiss-Steider
Summary: HPV-positive cervical cancer cells express the IL-2 receptor, with higher expression in HPV+ tumors. Transfection of HPV E6/E7 genes promotes IL-2R expression and enhances proliferation in CC cells. Furthermore, IL-2R plays a role in immune escape mechanisms in cervical cancer.
Article
Virology
Emily Montosa Nunes, Valeria Talpe-Nunes, Joao Simao Sobrinho, Silvaneide Ferreira, Vanesca de Souza Lino, Lara Termini, Gabriela Avila Fernandes Silva, Enrique Boccardo, Luisa Lina Villa, Laura Sichero
Summary: Studies suggest that HPV-18 variants from the A lineage have higher oncogenic potential compared to B variants, with uneven distribution in cervical adenocarcinomas and squamous cell carcinomas. Immortalized PHKs with HPV-18 A1 and B1 sublineages showed qualitative differences in colony formation, invasion ability, and resistance to apoptosis. Further investigation is needed to understand the mechanisms underlying these differences and their relevance to cervical cancer subtypes.
Letter
Dermatology
Flora Magnotti, Severine Valsesia, Purnima Gupta, Christa Flechtenmacher, Pierre Contard, Daniele Viarisio, Assunta Venuti, Melanie Wencker, Massimo Tommasino, Jacqueline Marvel, Thomas Henry
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Oncology
Yayi Zhao, Rossybelle P. Amorrortu, Neil A. Fenske, Basil Cherpelis, Jane L. Messina, Vernon K. Sondak, Anna R. Giuliano, Michael J. Schell, Tim Waterboer, Michael Pawlita, Sandrine McKay-Chopin, Tarik Gheit, Massimo Tommasino, Dana E. Rollison
Summary: The study investigated the association between UV radiation and various cutaneous viral infections, finding a positive correlation between UV exposure and three markers of Beta-HPV infection.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Infectious Diseases
Luisa Galati, Rosario N. Brancaccio, Purnima Gupta, Eugenie Lohmann, Alexis Robitaille, Racheal S. Dube Mandishora, Cyrille Cuenin, Raffaele Filotico, Jean-Damien Combes, Anna R. Giuliano, Maria Gabriella Dona, Massimo Tommasino, Tarik Gheit
Summary: Overall, our study found that alpha HPV types were more prevalent in MSM, beta HPV types were more common in MSW, and gamma HPV types were equally distributed among the three groups. Additionally, several putative novel PV types were identified in the anal mucosa of men with different sexual behaviors and HIV status.
JOURNAL OF INFECTION
(2021)
Article
Multidisciplinary Sciences
Richard Muwonge, Partha Basu, Tarik Gheit, Devasena Anantharaman, Yogesh Verma, Neerja Bhatla, Smita Joshi, Pulikottil O. Esmy, Usha Rani Reddy Poli, Anand Shah, Eric Zomawia, Surendra S. Shastri, Sharmila Pimple, Priya R. Prabhu, Sanjay Hingmire, Aruna Chiwate, Catherine Sauvaget, Eric Lucas, Sylla G. Malvi, Maqsood Siddiqi, Subha Sankaran, Thiraviam Pillai Rameshwari Ammal Kannan, Rintu Varghese, Uma Divate, Shachi Vashist, Gauravi Mishra, Radhika Jadhav, Massimo Tommasino, M. Radhakrishna Pillai, Rengaswamy Sankaranarayanan, Kasturi Jayant
Article
Oncology
Marta Tagliabue, Marisa Mena, Fausto Maffini, Tarik Gheit, Beatriz Quiros Blasco, Dana Holzinger, Sara Tous, Daniele Scelsi, Debora Riva, Enrica Grosso, Francesco Chu, Eric Lucas, Ruediger Ridder, Susanne Rrehm, Johannes Paul Bogers, Daniela Lepanto, Belen Lloveras Rubio, Rekha Vijay Kumar, Nitin Gangane, Omar Clavero, Michael Pawlita, Devasena Anantharaman, Madhavan Radhakrishna Pillai, Paul Brennan, Rengaswamy Sankaranarayanan, Marc Arbyn, Francesca Lombardi, Miren Taberna, Sara Gandini, Fausto Chiesa, Mohssen Ansarin, Laia Alemany, Massimo Tommasino, Susanna Chiocca
Article
Multidisciplinary Sciences
Racheal S. Dube Mandishora, Trine B. Rounge, Megan Fitzpatrick, Irene Kraus Christiansen, Ole Herman Ambur, Sonja Lagstroem, Babill Stray-Pedersen, Massimo Tommasino, Joel Palefsky, Zvavahera M. Chirenje
Summary: This study found moderate agreement between self-collected anal swabs and clinician-collected anal swabs in HPV genotyping, with no significant difference in the proportion of genotypes detected by either method. Self-collected anal swabs may be used as an alternative to clinician-collected anal swabs for HPV genotyping.
Article
Oncology
Cindy Simoens, Ivana Gorbaslieva, Tarik Gheit, Dana Holzinger, Eric Lucas, Ruediger Ridder, Susanne Rehm, Peter Vermeulen, Martin Lammens, Olivier M. Vanderveken, Rekha Vijay Kumar, Nitin Gangane, Alessandro Caniglia, Fausto Maffini, Maria Belen Lloveras Rubio, Devasena Anantharaman, Susanna Chiocca, Paul Brennan, Madhavan Radhakrishna Pillai, Rengaswamy Sankaranarayanan, Johannes Bogers, Michael Pawlita, Massimo Tommasino, Marc Arbyn
Summary: The study shows that the prevalence of HPV infection varies across anatomical sites in HNC patients in Belgium, with HPV16 being the most common genotype. The proportion of HPV-driven HNC is 10 times higher in OPC compared to OCC and LC in Belgium from 1980 to 2014.
CANCER EPIDEMIOLOGY
(2021)
Article
Oncology
Rossybelle P. Amorrortu, Yayi Zhao, Jane L. Messina, Michael J. Schell, Neil A. Fenske, Basil S. Cherpelis, Vernon K. Sondak, Anna R. Giuliano, Michael Pawlita, Sandrine McKay-Chopin, Tarik Gheit, Tim Waterboer, Massimo Tommasino, Dana E. Rollison
Summary: The study found no significant association between infections with MCPyV and other HPyV and cuSCC or BCC. Less than 4.5% of baseline MCPyV infections were detected in subsequently developed keratinocyte carcinoma tumors.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Dana E. Rollison, Rossybelle P. Amorrortu, Yayi Zhao, Jane L. Messina, Michael J. Schell, Neil A. Fenske, Basil S. Cherpelis, Anna R. Giuliano, Vernon K. Sondak, Michael Pawlita, Sandrine McKay-Chopin, Tarik Gheit, Tim Waterboer, Massimo Tommasino
Summary: The study found that beta-HPV detection in skin swabs is a significant predictor of cutaneous squamous cell carcinoma (cuSCC) risk, but only a small subset of cuSCC is etiologically linked to beta-HPV infection. No clear patterns were observed between baseline beta-HPV detection and subsequent development of basal cell carcinoma (BCC), or between baseline gamma-HPV detection and either cuSCC or BCC.
Article
Otorhinolaryngology
Martina Bertinazzi, Tarik Gheit, Jerry Polesel, Sandrine McKay-Chopin, Cesare Cutrone, Marianna Sari, Marta Sbaraglia, Angelo Paolo Dei Tos, Piero Nicolai, Massimo Tommasino, Paolo Boscolo-Rizzo
Summary: The study aimed to evaluate the prevalence of different HPV genera in JoRRP and examine the association of viral features with clinical outcomes. Results suggested a correlation between the number of different HPV co-infections and the severity of the disease in JoRRP patients.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Biochemical Research Methods
Rosario N. Brancaccio, Alexis Robitaille, Sankhadeep Dutta, Dana E. Rollison, Massimo Tommasino, Tarik Gheit
Summary: The use of the MinION nanopore sequencer enables the generation of ultra-long reads for more effective characterization of viral genome sequences. The study results demonstrate that the MinION sequencer is an effective strategy for whole-genome sequencing of HPVs with minimal error rates.
JOURNAL OF VIROLOGICAL METHODS
(2021)
Article
Medicine, General & Internal
Massimo Giuliani, Tarik Gheit, Francesca Rollo, Massimo Tommasino, Alessandra Latini, Maria Benevolo, Barbara Pichi, Raul Pellini, Sandrine McKay-Chopin, Antonio Cristaudo, Eugenia Giuliani, Aldo Morrone, Maria Gabriella Dona
Summary: Predictors of oral infection differ between HIV-infected and uninfected men who have sex with men (MSM), as well as between alpha and beta/gamma HPVs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Partha Basu, Sylla G. Malvi, Smita Joshi, Neerja Bhatla, Richard Muwonge, Eric Lucas, Yogesh Verma, Pulikkottil O. Esmy, Usha Rani Reddy Poli, Anand Shah, Eric Zomawia, Sharmila Pimple, Kasturi Jayant, Sanjay Hingmire, Aruna Chiwate, Uma Divate, Shachi Vashist, Gauravi Mishra, Radhika Jadhav, Maqsood Siddiqi, Subha Sankaran, Priya Ramesh Prabhu, Thiraviam Pillai Rameshwari Ammal Kannan, Rintu Varghese, Surendra S. Shastri, Devasena Anantharaman, Tarik Gheit, Massimo Tommasino, Catherine Sauvaget, M. Radhakrishna Pillai, Rengaswamy Sankaranarayanan
Summary: This study in India compared the efficacy of single dose HPV vaccine with two and three doses in protecting against persistent HPV 16 and 18 infection over a 10-year period. The research found that a single dose of the vaccine provided similar protection against these infections as two or three doses, which are responsible for nearly 70% of cervical cancers.
Article
Immunology
Iacopo Baussano, Felix Sayinzoga, Ugyen Tshomo, Vanessa Tenet, Alex Vorsters, Danielle A. M. Heideman, Tarik Gheit, Massimo Tommasino, Marie Chantal Umulisa, Silvia Franceschi, Gary M. Clifford
Summary: The study showed that in Rwanda and Bhutan, the school-based national HPV vaccination programs implemented in 2011 and 2010 were highly effective in reducing the prevalence of vaccine-targeted HPV types and other alpha-9 types. The overall effectiveness varied slightly between the two countries, but both demonstrated significant reductions in HPV infection rates.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Virology
Luisa Galati, Rosario Nicola Brancaccio, Alexis Robitaille, Cyrille Cuenin, Fabiola Luzi, Gianna Fiorucci, Maria Vincenza Chiantore, Nadia Marascio, Giovanni Matera, Maria Carla Liberto, Maria Gabriella Dona, Paola Di Bonito, Tarik Gheit, Massimo Tommasino
PAPILLOMAVIRUS RESEARCH
(2020)