期刊
SEMINARS IN CANCER BIOLOGY
卷 21, 期 1, 页码 4-9出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2010.09.002
关键词
Microarray gene signatures; Proliferation genes; Polo-like kinase 1 (PLK1); Epithelial cell adhesion molecule (EpCAM); Hepatic progenitors and cancer initiating/stem cells; Polycomb repressive complex 2 (PRC2)
类别
资金
- NIH [DK044533, CA135192]
- Purdue University
Primary hepatocellular carcinoma (HCC) is a significant human cancer globally, with poor prognosis. New and efficacious therapy strategies are needed as well as new biomarkers for early detection of at-risk patients. In this review, we discuss select microarray studies of human HCCs, and propose a gene signature that has promise for clinical/translational application. This gene signature combines the proliferation cluster of genes and the hepatic cancer initiating/stem cell gene cluster for identification of HCCs with poor prognosis. Evidence from cell-based assays identifies the existence of a mechanistic link between these two gene clusters, involving the proliferation cluster gene polo-like kinase 1 (PLK1). We propose that PLK1 is a promising therapy target for HCC. (C) 2010 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据