期刊
SEMINARS IN CANCER BIOLOGY
卷 19, 期 4, 页码 270-275出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2009.04.001
关键词
KI; WU; Merkel cell polyomaviruses
类别
资金
- Swedish Cancer Foundation
- Swedish Medical Research Council
- Gustav Vth jubilee Society
- Stockholm Cancer Society
- European Union [LSHB-CT-2004-005246]
- Stockholm City Council
- Karolinska Institutet
- NIH/NCI [CA37667]
The recent discoveries of KI, WU, and Merkel cell polyomaviruses (PyVs) have rekindled interest in the Polyomaviridae and their relation to human disease. Although it may be too early to draw firm conclusions, it seems apparent that these new viruses follow precedents established by other Py viruses: a benign initial infection at an early age, widespread prevalence in the population, and pathologic consequences only in the elderly and/or immunosuppressed. The discovery of Merkel cell PyV (MCPyV) integration into the malignant cell genome immediately implicates this agent in an oncogenic process predicted by previous research with SV40 and murine PyV (MPyV). Their discovery is another reminder that we certainly have not seen the end of novel human polyomavirus identification, but rather the beginning of a new era. (C) 2009 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据