Article
Immunology
Michelle W. Huang, Ariel D. Stock, Chaim Putterman
Summary: Treatment with anti-CXCL13 significantly improves cognitive function and depression-like behavior in MRL/lpr mice, regardless of the route of administration. However, it does not substantially change the extent of lymphocyte infiltration into the brain or the general composition of the aggregates. Analysis of brain gene expression in anti-CXCL13 treated mice reveals significant differences in key immunological and neuro-inflammatory pathways, which likely explain the improvement in behavioral phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Yuhong Liu, Zhihua Tu, Xi Zhang, Keqian Du, Zhengquan Xie, Zhiming Lin
Summary: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease with a complex pathogenesis. Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication of SLE that involves the nervous system and produces neurological or psychiatric symptoms. The mechanisms of NPSLE involve genetic factors, blood-brain barrier dysfunction, vascular lesions, multiple autoimmune antibodies, cytokines, and neuronal cell death. Due to the complexity and clinical overlap with other neurological or psychiatric disorders, the accurate diagnosis and treatment of NPSLE is challenging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Jijuan Yang, Chun Li, Shuhong Chi, Hongliang Wei, Wenqing Du, Qikuan Hu
Summary: This study identified the upregulation of miRNA miR-762 in both SLE and NPSLE samples, which can suppress the expression of GIPC3 and may be involved in the development of SLE and NPSLE.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Medicine, General & Internal
Yasser M. Bawazir, Sami Bahlas, Ibtisam Jali, Deyaa A. Mukhtar, Nujood Almohammmadi, Mohammad Mustafa
Summary: This retrospective study analyzed the MRI findings of 187 lupus patients and their correlation with complement levels, finding an MRI abnormality rate of 51% in neuropsychiatric systemic lupus patients, predominantly white matter changes. However, there was no statistically significant relationship found between C3/C4 levels and white matter lesions in this sample.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Holger Haas, Sahand Tabatabaei, William Rose, Pardis Sahafi, Michele Piscitelli, Andrew Jordan, Pritam Priyadarsi, Namanish Singh, Ben Yager, Philip J. Poole, Dan Dalacu, Raffi Budakian
Summary: This article combines ultrasensitive force-based spin detection with high-fidelity spin control to achieve NMR diffraction measurement of millions of 31P spins in a nanowire. The experiments demonstrate subangstrom precision in detecting spatial modulation of spins and angstrom-scale displacement of the sample. The diffraction-based techniques extend the capabilities of NMR to the angstrom scale and show the potential of NMRd in probing nanocrystalline materials.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Trang T. T. Hoang, Kunihiro Ichinose, Shimpei Morimoto, Kaori Furukawa, Ly H. T. Le, Atsushi Kawakami
Summary: This study identified critical serum biomarkers for the development of NPSLE, which could have clinical utility in predicting and intervening the disease progression before the onset of neuropsychiatric symptoms.
CLINICAL IMMUNOLOGY
(2022)
Article
Clinical Neurology
Sinah Engel, Simone Boedecker, Paul Marczynski, Stefan Bittner, Falk Steffen, Arndt Weinmann, Andreas Schwarting, Frauke Zipp, Julia Weinmann-Menke, Felix Luessi
Summary: The study evaluated the diagnostic potential of sNfL in NPSLE patients and found significantly higher levels in NPSLE patients compared to SLE patients without neuropsychiatric manifestations, particularly in those with CNS involvement. Age and serum creatinine concentrations were identified as relevant contributors to sNfL levels.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Article
Immunology
Wataru Nagata, Akiho Koizumi, Keiichi Nakagawa, Sayaka Takahashi, Mari Gotoh, Yasushi Satoh, Toshiaki Ishizuka
Summary: Novel therapeutic options are required for NPSLE. MRL/lpr mice showed increased depressive-like behaviors and expression of microglia in the brain compared to MRL/+ mice, which was significantly suppressed by LPA treatment. LPA may regulate microglial activation, blood-brain-barrier weakening, and depression-like behaviors in NPSLE.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Rheumatology
Benzeeta Pinto, Sumatha C. Suresh, Kodali Ramyasri, Girish Narayan, Deepa Susan, Sandra Manuel, Aishwarya Wodeyar, Archana Shivanna, Ramya Janardana, Kodishala Chanakya, B. Sheba Charles, Sangeetha K. Nanjundaswamy, Anu M. Desai, Raghunandan Nadig, Vineeta Shobha
Summary: The objective of this study was to investigate the prevalence of different neuropsychiatric systemic lupus erythematosus (NPSLE) manifestations in our cohort and compare the clinical and immunological features and outcomes, including mortality, of NPSLE patients and systemic lupus erythematosus (SLE) controls without neuropsychiatric involvement. The study found that seizures and cerebrovascular accidents were the most common NPSLE syndromes in our patients. The presence of NPSLE was associated with high mortality in Indian lupus patients.
Article
Multidisciplinary Sciences
Julius Akesson, Ellen Ostenfeld, Marcus Carlsson, Hakan Arheden, Einar Heiberg
Summary: A clinical pipeline based on deep learning was developed for right ventricular (RV) delineations in cardiac magnetic resonance (CMR) images, which showed the ability to substantially reduce the time needed for manual delineations. The automated delineations were rated as sufficient for clinical use in 58% of cases, and the average time reduction compared to manual delineations was 87%.
SCIENTIFIC REPORTS
(2023)
Review
Pediatrics
Ariunzaya Amgalan, Nickie Andescavage, Catherine Limperopoulos
Summary: Research shows that neuropsychiatric diseases have developmental origins related to intrauterine exposures, particularly affected by factors such as infection and inflammation. Identifying the timing and mechanisms of injury is crucial in studying fetal brain development, and clinical care should focus on maternal health during pregnancy and monitoring offspring for early recognition and treatment.
Article
Acoustics
S. C. Shelmerdine, N. J. Sebire, O. J. Arthurs
Summary: The diagnostic accuracy of postmortem ultrasound (PM-US) and postmortem magnetic resonance imaging (PM-MRI) for perinatal autopsy is similar, with high concordance rates for overall diagnosis and individual anatomical regions.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Rheumatology
Patricia Corzo Garcia, Ivan Garcia-Duitama, Anna Agusti Claramunt, Xavier Duran Jorda, Jordi Monfort, Tarek C. Salman-Monte
Summary: Objective Joint involvement in SLE is frequent but underestimated. This study used contrasted MRI to describe the prevalence of joint and tendon involvement in hand and wrist of SLE patients, including those without symptoms. The results showed a high prevalence of inflammatory musculoskeletal alterations in SLE patients.
Article
Multidisciplinary Sciences
Shakthi Kumaran Ramasamy, Raheleh Roudi, Wipawee Morakote, Lisa C. Adams, Laura J. Pisani, Michael Moseley, Heike E. Daldrup-Link
Summary: T2* relaxometry is an established method for measuring the effect of superparamagnetic iron oxide nanoparticles on tumor tissues using MRI. This study presents a protocol for measuring tumor T2* relaxation times using multi-echo gradient echo sequences and external software, which allows for scanner-independent comparison of imaging data from different sources. The protocol has been validated with preclinical and clinical data, and could improve the standardization and reproducibility of tumor T2* measurements in multi-center studies.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simon Elbaze, Loic Duron, Natasha Mambour, Mathieu Zmuda, Sidney Krystal, Jessica Guillaume, Julien Savatovsky, Augustin Lecler
Summary: Structural MRI can differentiate OCVM from other orbital lesions. OCVM is characterized by higher signal intensity on T2WI, chemical shift artifact, and a single starting point of enhancement. Structural MRI has high sensitivity and specificity in diagnosing OCVM.
EUROPEAN RADIOLOGY
(2023)
Article
Neuroimaging
Raeesa Gupte, Sarah Christian, Paul Keselman, Joshua Habiger, William M. Brooks, Janna L. Harris
BRAIN IMAGING AND BEHAVIOR
(2019)
Article
Rheumatology
N. Suzanne Emil, David R. Cisneros, Santhi Penmetsa, Joshua H. Duchesne, Wilmer L. Sibbitt, James I. Gibb, Leonard E. Noronha, Monthida Fangtham, Roderick A. Fields, Arthur D. Bankhurst
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2020)
Article
Developmental Biology
Rebecca J. Lepping, Robyn A. Honea, Laura E. Martin, Ke Liao, In-Young Choi, Phil Lee, Vlad B. Papa, William M. Brooks, D. Jill Shaddy, Susan E. Carlson, John Colombo, Kathleen M. Gustafson
DEVELOPMENTAL PSYCHOBIOLOGY
(2019)
Review
Critical Care Medicine
Raeesa Gupte, William Brooks, Rachel Vukas, Janet Pierce, Janna Harris
JOURNAL OF NEUROTRAUMA
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
Paola Roldan, Manuel Cortes, Ernest Greene, Clifford Qualls, Wilmer Sibbitt, Carlos Roldan
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Rheumatology
Paola C. Roldan, Ernest R. Greene, Clifford R. Qualls, Wilmer L. Sibbitt, Carlos A. Roldan
RHEUMATOLOGY INTERNATIONAL
(2019)
Article
Rheumatology
Maheswari Muruganandam, Noelle A. Rolle, Wilmer L. Sibbitt, Gladys B. Cook, N. Suzanne Emil, Monthida Fangtham, Kimberly J. Reiter, Arthur D. Bankhurst
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2019)
Article
Rheumatology
Noelle A. Rolle, Irum Jan, Wilmer L. Sibbitt, Philip A. Band, Luke J. Haseler, William A. Hayward, Maheswari Muruganandam, N. Suzanne Emil, Monthida Fangtham, Arthur D. Bankhurst
CLINICAL RHEUMATOLOGY
(2019)
Review
Rheumatology
Albert H. Redford, Jaren R. Trost, Wilmer L. Sibbitt, Monthida Fangtham, N. Suzanne Emil, Shalini Singh, Arthur D. Bankhurst
RHEUMATOLOGY INTERNATIONAL
(2019)
Article
Neurosciences
Hannes Devos, Kathleen Gustafson, Pedram Ahmadnezhad, Ke Liao, Jonathan D. Mahnken, William M. Brooks, Jeffrey M. Burns
Article
Urology & Nephrology
Michael Grasing, Palash Sharma, Rebecca J. Lepping, Robyn Honea, Jeffrey M. Burns, William M. Brooks, Aditi Gupta
Summary: This study used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to investigate the association between estimated glomerular filtration rate (eGFR) and brain volumes. The results indicate that mild to moderate kidney dysfunction is not associated with brain atrophy.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Letter
Rheumatology
Reem Alkilany, Joshua A. Hanson, Noelle A. Rolle, Roderick A. Fields, Wilmer L. Sibbitt
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2021)
Meeting Abstract
Rheumatology
Fatemeh Jafari Farshami, Jaren Trost, Wilmer Sibbitt, Maheswari Muruganandam, Philip Band, Monthida Fangtham, Nicole Emil, William Hayward, Luke Haseler, Arthur Bankhurst
ARTHRITIS & RHEUMATOLOGY
(2019)
Meeting Abstract
Surgery
A. Gupta, P. Lee, R. Lepping, A. Jurgensen, J. Klein, P. Adany, I. Cibrik, J. Burns, W. Brooks, I. Choi
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Meeting Abstract
Surgery
A. Gupta, I. Choi, R. Lepping, P. Adany, A. Jurgensen, J. Klein, D. Cibrik, J. Burns, W. Brooks, P. Lee
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Rheumatology
Walter P. Maksymowych, Nele Herregods, Nisha Varma, Arthur B. Meyers, Jennifer Stimec, Andrea S. Doria, Nikolay Tzaribachev, Tarimobo M. Otobo, Marion A. van Rossum, Joel Paschke, Stephanie Wichuk, Robert G. Lambert
Summary: This study aimed to investigate whether systematic calibration improves the scoring proficiency of JAMRIS-SIJ and whether contrast-enhancement enhances its performance. The results showed that calibrated readers achieved greater reliability in scoring specific inflammatory and structural lesions. Sensitivity and reliability for scoring inflammatory lesions were higher on fluid-sensitive sequences compared to contrast-enhanced sequences. Therefore, systematic calibration should be implemented before using JAMRIS-SIJ in clinical trials, and it is unlikely that contrast-enhanced MRI will improve the performance of this method.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
L. van Ouwerkerk, S. A. Bergstra, T. D. Maarseveen, T. W. J. Huizinga, R. Knevel, C. F. Allaart
Summary: This study evaluated whether the initial use of glucocorticoid (GC) bridging in RA patients leads to a higher probability of long-term GC and bDMARD use. The results showed that patients who initially started GC had a higher risk of later GC use, but the risk of bDMARD use was not significantly increased.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
ShuangHua Liu, YiMei Tan, WeiDong Huang, HongSheng Luo, BingCheng Pan, Shuan Wu
Summary: This study assessed the cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis. The results showed that in women with primary osteoporosis, zoledronic acid may increase the risk of atrial fibrillation and arrhythmias, but the cardiovascular risk in men with osteoporosis is uncertain.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)