Article
Clinical Neurology
Mengting Huang, Xin Li, Wenliang Fan, Jing Li, Liangru Zhu, Ping Lei, Linxia Wu, Qing Sun, Yan Zou, Ping Han
Summary: Abnormal psychological processing in the central nervous system has been found in Crohn's disease patients. Active patients exhibit more severe psychological assessment disorder scores and different patterns of brain activity compared to inactive patients and healthy controls. The findings suggest that psychological factors may play a critical role in the brain function of Crohn's disease.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychology, Multidisciplinary
H. Schulte-Goecking, M. Azqueta-Gavaldon, C. Storz, M. Woiczinski, P. Fraenkel, J. Leukert, S. C. Azad, E. Kraft
Summary: Body Perception Disturbance (BPD) in Complex Regional Pain Syndrome (CRPS) is a poorly understood phenomenon. This study found significant correlations between BPD and depression, anxiety, current stress, quality of life, and pain intensity in CRPS patients. However, BPD was not influenced by childhood trauma or duration of illness. Future research should focus on identifying which patients are more likely to develop psychological conditions in order to provide early intervention.
CURRENT PSYCHOLOGY
(2022)
Article
Neurosciences
Xue Liu, Shaowei Liu, Tao Liu, Liang Tang, Mufan Ji, Yan Xu, Ziliang Xiang, Jianwen Zhou, Yun Chen, Jianhuai Chen
Summary: This study aimed to explore the abnormalities of brain function in psychological erectile dysfunction (pED) patients and their relationships with sexual behavior and emotion. Resting state functional magnetic resonance imaging (rs-fMRI) data were collected and compared between 31 pED patients and 31 healthy controls. The results showed altered brain function in the medial superior frontal gyrus, caudate, and putamen of pED patients, which were associated with sexual function and psychological condition.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Nutrition & Dietetics
Spyridon Tsirigkakis, George Mastorakos, Yiannis Koutedakis, Vassilis Mougios, Alan M. Nevill, Zoe Pafili, Gregory C. Bogdanis
Summary: A study comparing two high-intensity interval training protocols on obese men showed similar effects in improving regional body composition and fat oxidation. Both training programs effectively reduced trunk fat and increased leg lean mass, while enhancing fat oxidation during exercise. HIIT also resulted in improved peak fat oxidation, VO2peak, and decreased blood lactate levels at submaximal intensities.
Article
Environmental Sciences
Hoa Thi Vu, Thao Ngoc Pham, Takashi Yokawa, Muneko Nishijo, Tai Pham The, Quyet Do, Yoshikazu Nishino, Hisao Nishijo
Summary: The study found that high levels of dioxin exposure may lead to brain structural irregularities in Vietnamese men, particularly in terms of regional gray matter volumes. Perinatal and adulthood exposure to dioxin may alter regional brain volume, potentially resulting in cognitive deficits and unusual social emotional behavior.
Review
Anesthesiology
Marc-Henri Louis, Caroline Meyer, Valery Legrain, Anne Berquin
Summary: This systematic review aimed to identify prognostic factors in adult individuals with early CRPS. It found 21 early factors associated with a poorer prognosis in type I CRPS, with moderate evidence supporting six of them. The study highlights the lack of knowledge about early prognostic factors in CRPS and calls for larger studies to determine which patients are vulnerable to chronification.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Neuroimaging
Jordi P. D. Kleinloog, Ronald P. Mensink, Ellen T. H. C. Smeets, Dimo Ivanov, Peter J. Joris
Summary: This study aimed to investigate the acute effects of inorganic nitrate on regional cerebral blood flow (CBF) responses to intranasal insulin in abdominally obese men. The results showed that inorganic nitrate intake increased insulin action in specific brain regions, which play a regulatory role in different metabolic and cognitive processes.
NEUROIMAGE-CLINICAL
(2022)
Article
Physiology
Sisitha Udara Jayasinghe, Sarah Janet Hall, Susan Jane Torres, Anne Isabella Turner
Summary: The overall response to acute psychological stress involves both the sympathoadrenal medullary (SAM) system and the hypothalamo-pituitary adrenal (HPA) axis. Dysregulation of the stress systems may not be evident when considering each system separately. Men with elevated adiposity showed a blunted cortisol response per unit of blood pressure response, indicating a coordinated overall approach to activation of the stress pathways.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Urology & Nephrology
Filippo Maria Nimbi, Campedelli Virginia, Di Monte Cinzia, Di Trani Michela, Silecchia Gianfranco, Paone Emanuela
Summary: This study investigated the impact of obesity on sexuality and found significant associations between sexual desire, erectile function, orgasmic function, intercourse satisfaction, general satisfaction, and other psychological constructs such as difficulties in identifying feelings, psychopathological symptoms, body image, and quality of life.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2022)
Article
Medicine, General & Internal
Hessah M. Al-Muzafar, Mohammed T. Al-Hariri
Summary: The study found that serum manganese levels in the nails of women with obesity were significantly lower compared to those without obesity, and were influenced by factors like regular sports activity and consumption of fruits, vegetables, fish, meat, and water. Further research is needed to determine if Saudi women are at risk for manganese deficiency.
JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES
(2021)
Review
Neurosciences
Sook-Lei Liew, Artemis Zavaliangos-Petropulu, Neda Jahanshad, Catherine E. Lang, Kathryn S. Hayward, Keith R. Lohse, Julia M. Juliano, Francesca Assogna, Lee A. Baugh, Anup K. Bhattacharya, Bavrina Bigjahan, Michael R. Borich, Lara A. Boyd, Amy Brodtmann, Cathrin M. Buetefisch, Winston D. Byblow, Jessica M. Cassidy, Adriana B. Conforto, R. Cameron Craddock, Michael A. Dimyan, Adrienne N. Dula, Elsa Ermer, Mark R. Etherton, Kelene A. Fercho, Chris M. Gregory, Shahram Hadidchi, Jess A. Holguin, Darryl H. Hwang, Simon Jung, Steven A. Kautz, Mohamed Salah Khlif, Nima Khoshab, Bokkyu Kim, Hosung Kim, Amy Kuceyeski, Martin Lotze, Bradley J. MacIntosh, John L. Margetis, Feroze B. Mohamed, Fabrizio Piras, Ander Ramos-Murguialday, Genevieve Richard, Pamela Roberts, Andrew D. Robertson, Jane M. Rondina, Natalia S. Rost, Nerses Sanossian, Nicolas Schweighofer, Na Jin Seo, Mark S. Shiroishi, Surjo R. Soekadar, Gianfranco Spalletta, Cathy M. Stinear, Anisha Suri, Wai Kwong W. Tang, Gregory T. Thielman, Daniela Vecchio, Arno Villringer, Nick S. Ward, Emilio Werden, Lars T. Westlye, Carolee Winstein, George F. Wittenberg, Kristin A. Wong, Chunshui Yu, Steven C. Cramer, Paul M. Thompson
Summary: The ENIGMA Stroke Recovery working group aims to understand the relationship between brain and behavior using meta- and mega-analytic approaches. They have developed neuroinformatics protocols and methods to manage large-scale data from over 2,100 stroke patients. The challenges and recommendations for data harmonization in stroke research are discussed.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Jie Sun, Yingying Xie, Qiuhui Wang, Junlin Shen, Wen Qin, Ningnannan Zhang, Chunshui Yu
Summary: The study identified 623 genes associated with grey matter volume reduction in multiple sclerosis, which are functionally related to ion channel, synaptic transmission, axon, and neuron projection. These genes show significant enrichment for MS-related genes identified by GWAS and are more significantly expressed in neurons than other cell types, indicating a potential role in the development of grey matter atrophy in MS.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Fenglian Zheng, Yuxin Li, Zhizheng Zhuo, Yunyun Duan, Guanmei Cao, Decai Tian, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Haiqing Li, Yongmei Li, Chun Zeng, Ningnannan Zhang, Jie Sun, Chunshui Yu, Xuemei Han, Sven Hallar, Frederik Barkhof, Yaou Liu
Summary: In a study involving 752 participants, it was found that MS patients had significantly lower hippocampal volume, FA, and MD compared to NMOSD patients and healthy controls, but no abnormal ALFF or DC were identified in any group. Hippocampal subfields were affected in both diseases, but some subfield volumes were significantly lower only in MS patients.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Neurosciences
Jianfeng Zhang, Dong-Qiang Liu, Shufang Qian, Xiujuan Qu, Peiwen Zhang, Nai Ding, Yu-Feng Zang
Summary: This study investigates the neural correlates of fMRI-ALFF by comparing the amplitude differences between eyes-closed and eyes-open states in fMRI and MEG. The results show that MEG-ALFF increases at parietal sensors, overlapping with the EC-EO differences observed in fMRI. These findings suggest that the amplitude in MEG reflects distinct physiological information and that fMRI-ALFF may be related to the ALFF in neural activity.
Article
Computer Science, Interdisciplinary Applications
Na Zhao, Juan Yue, Zi-Jian Feng, Yang Qiao, Qiu Ge, Li-Xia Yuan, Jue Wang, Yu-Tao Xiang, Yu-Feng Zang
Summary: This study aimed to investigate the reliability of RS-fMRI FC location and the impact of various factors on FC strength. The results showed low to moderate reliability of FC strength, while the center of gravity (COG) of seed-based FC had smaller distances, suggesting it as a potential stimulation target.
Article
Biochemistry & Molecular Biology
Feng Liu, Jiayuan Xu, Lining Guo, Wen Qin, Meng Liang, Gunter Schumann, Chunshui Yu
Summary: Individual differences in human brain structure, function, and behavior can be explained by genetic variations, environmental exposures, and their interactions. While genetic variants associated with brain imaging phenotypes have been identified, the environmental exposures related to these phenotypes are largely unknown. This study proposes that research in environmental neuroscience should focus on understanding the associations between lifetime environmental exposures and brain imaging phenotypes, as well as identifying cumulative environmental effects and their vulnerable age windows.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Jingchun Liu, Caihong Wang, Wen Qin, Hao Ding, Yanmin Peng, Jun Guo, Tong Han, Jingliang Cheng, Chunshui Yu
Summary: Subcortical ischemic stroke can cause long-lasting changes in the cerebral cortex. This study investigated the relationship between cortical structural changes, motor recovery, lesion location, and early impairment of specific subsets of fibers in the corticospinal tract (CST) in patients with subcortical stroke. The findings revealed different patterns of cortical structural changes in patients with partial and complete recovery, which were associated with lesion location and impairment of specific CST fiber subsets.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Melanie Storch, Maria Kanthack, Till Amelung, Klaus M. Beier, Tillmann H. C. Krueger, Christopher Sinke, Henrik Walter, Martin Walter, Boris Schiffer, Stephanie Schindler, Peter Schoenknecht
Summary: The study highlights the importance of differentiating between sexual offending and paraphilic sexual preferences, as a deviant hypothalamic structure was found to be a neurobiological correlate of child sexual offenses in pedophiles but not in individuals with pedophilia who have not committed offenses.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Juan Yue, Na Zhao, Yang Qiao, Zi-Jian Feng, Yun-Song Hu, Qiu Ge, Tian-Qing Zhang, Zhu-Qian Zhang, Jue Wang, Yu-Feng Zang
Summary: This study tested the reliability and validity of a new functional magnetic resonance imaging (fMRI) metric called Wavelet-ALFF, and applied it to investigate the modulation effect of repetitive transcranial magnetic stimulation (rTMS). The results showed that Wavelet-ALFF had higher reliability and validity compared to the previous metric FFT-ALFF, especially in higher frequency bands. Wavelet db2-ALFF showed the best reliability and validity, suggesting it can be a powerful tool for examining regional spontaneous brain activities in future studies.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Huaigui Liu, Wei Li, Nana Liu, Jie Tang, Lixin Sun, Jiayuan Xu, Yuan Ji, Yingying Xie, Hao Ding, Zhaoxiang Ye, Chunshui Yu, Wen Qin
Summary: Evidence suggests that dysregulation of the dopamine (DA) system and dysfunction of the prefrontal cortex (PFC) may contribute to the development of schizophrenia. However, the relationship between DA genes, PFC morphology, and schizophrenia is still not fully understood. In this study, we analyzed brain gene expression data and structural magnetic resonance imaging data to identify specific PFC subregions that are associated with the expression profiles of DA genes. We found that some PFC subregions showed abnormal increases in gray matter volume covariance with other brain regions in schizophrenia patients. Furthermore, our analysis of postmortem expression data revealed reduced coexpression of DA genes between the middle frontal gyrus and hippocampus in schizophrenia patients, with these genes being implicated in brain functions related to working memory, reward processing, speech production, and episodic memory.
Article
Neurosciences
Wenshuang Zhu, Feng Liu, Jilian Fu, Wen Qin, Kaizhong Xue, Jie Tang, Yong Zhang, Chunshui Yu
Summary: This study identified 903 clinically sensitive genes and 633 clinically insensitive genes associated with ALFF alterations in MDD. The sensitive genes were enriched for cell differentiation and development, while the insensitive genes were enriched for ion transport and synaptic signaling.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neuroimaging
Ling Wang, Yi Ji, Hao Ding, Qin Tian, Ke Fan, Dapeng Shi, Chunshui Yu, Wen Qin
Summary: The study used arterial spin labeling (ASL) to investigate abnormal cerebral blood flow (CBF) in patients with Leber's hereditary optic neuropathy (LHON) and its associations with disease duration and neuro-ophthalmological impairment. The results showed differences in brain regions of LHON patients, including the left sensorimotor and bilateral visual areas. LHON patients had lower CBF in the bilateral calcarine compared to healthy controls. Chronic LHON patients also showed lower CBF in the left middle frontal gyrus, sensorimotor cortex, and temporal-partial junction. Disease duration and neuro-ophthalmological impairments were found to affect the metabolism of non-visual areas.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Neurosciences
Luisa Herrmann, Johanna Ade, Anne Kuehnel, Annina Widmann, Liliana Ramona Demenescu, Meng Li, Nils Opel, Oliver Speck, Martin Walter, Lejla Colic
Summary: High childhood emotional maltreatment (CM-EMO) is associated with an increased risk for psychopathology, potentially through alterations in gamma-Aminobutyric acid (GABA). The pregenual anterior cingulate cortex (pgACC) is an important brain region for emotion processing, and its' GABA levels are implicated in mood and anxiety disorders. This study examined the association between self-reported CM-EMO in adulthood and GABA+ levels in the pgACC, finding a negative relationship between CM-EMO-NEG and GABA+/tCr in the pgACC.
NEUROBIOLOGY OF STRESS
(2023)
Article
Neurosciences
Zi-Jian Feng, Qiu-Ying Song, Yu Han, Zi-Yu Wei, Cong Fu, Yu-Feng Zang
Summary: This case report investigates the short-term effects of functional connectivity-guided rTMS with coil handle orientations of posterior-anterior 45 degrees (PA45 degrees) and posterior-anterior 135 degrees (PA135 degrees) on a patient with insomnia. The results show that the PA45 degrees orientation outperforms the PA135 degrees orientation in both resting-state functional magnetic resonance imaging and motor evoked potentials outcomes. Additionally, a 9-day rTMS treatment leads to improvements in symptoms of depression and anxiety, as well as a modest enhancement in sleep quality.
CLINICAL NEUROPHYSIOLOGY PRACTICE
(2023)
Article
Clinical Neurology
Kaori L. Ito, Bokkyu Kim, Jingchun Liu, Surjo R. Soekadar, Carolee Winstein, Chunshui Yu, Steven C. Cramer, Nicolas Schweighofer, Sook-Lei Liew
Summary: This retrospective study found that evaluating CST-LL from additional motor origins, such as the ventral premotor cortex, is more strongly associated with post-stroke motor severity than using CST-LL originating from primary motor cortex alone. This suggests that higher order motor regions add clinical relevance to motor impairment.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
