Article
Nutrition & Dietetics
Simone Perna, Cinzia Ferraris, Monica Guglielmetti, Tariq A. Alalwan, Alaa M. Mahdi, Davide Guido, Anna Tagliabue
Summary: This study assessed the efficacy and side effects of the classic ketogenic diet (cKD) in children with drug-resistant epilepsy in Bahrain. The results showed that cKD was effective in reducing seizure rates, with a significant increase in triglycerides and albumin levels. Although there were some increases in cholesterol and alanine transaminase levels, they were not statistically significant. Adherence to the diet was influenced by the duration of cKD and age at cKD initiation. Close monitoring and emphasis on healthy fats are important when using cKD as a treatment for epilepsy.
Article
Nutrition & Dietetics
Mariana Baldini Prudencio, Patricia Azevedo de Lima, Daniela Kawamoto Murakami, Leticia Pereira de Brito Sampaio, Nagila Raquel Teixeira Damasceno
Summary: This study found that the ketogenic diet did not provide sufficient micronutrients and supplementation did not fully address the deficiency, particularly in calcium, magnesium, and phosphorus. Therefore, individualized supplementation protocols and monitoring of micronutrient intake according to age and sex are crucial.
Article
Multidisciplinary Sciences
Wael Abu Dayyih, Raghad Layth, Mohammad Hailat, Bayan Alkhawaja, Lina Al Tamimi, Zainab Zakaraya, Aseel Aburumman, Nisreen Al Dmour, Mohamed J. Saadh, Hisham Al-Matubsi, Saed M. Aldalaen
Summary: In this study, it was found that administering date molasses to rats significantly decreased the pharmacokinetic parameters of levetiracetam, which could increase the risk of epileptic seizures.
SCIENTIFIC REPORTS
(2023)
Review
Nutrition & Dietetics
Cristina Diez-Arroyo, Monica Garcia-Garcia, Maria Jose Soto-Mendez, Esther Molina-Montes, Mercedes Gil-Campos, Angel Gil, Miriam Gutierrez-Jimeno, Angela Hernandez-Ruiz
Summary: Epilepsy is a common neurological disorder in childhood, and despite antiepileptic drugs being the preferred treatment, a significant number of children continue to experience seizures. This review examines the use of a ketogenic diet (KD) as an alternative treatment for refractory epilepsy in children.
Article
Behavioral Sciences
Tzu-Yun Hsieh, Ting-Yu Su, Kai-Yin Hung, Mei-Shin Hsu, Ying-Jui Lin, Hsuan-Chang Kuo, Pi-Lien Hung
Summary: This study investigated the feasibility, tolerability, efficacy, and safety of ketogenic diet therapy (KDT) for controlling seizures in infants under 2 years old. The results showed that 84.6% of patients responded to KDT, and no significant adverse effects or growth retardation were observed.
EPILEPSY & BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Alex M. Dickens, Tory P. Johnson, Santosh Lamichhane, Anupama Kumar, Carlos A. Pardo, Erie G. Gutierrez, Norman Haughey, Mackenzie C. Cervenka
Summary: This study investigates the clinical outcomes and related factors in patients with super-refractory status epilepticus (SRSE) treated with a ketogenic diet. The results show a significant reduction in pro-inflammatory mediators IL-6 and CXCL13 after 1 and 2 weeks of ketogenic diet treatment, while higher levels of β-hydroxybutyrate in the blood are associated with better clinical outcomes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ara Ko, Hye Eun Kwon, Heung Dong Kim
Summary: The ketogenic diet is a high-fat, low-carbohydrate diet that utilizes ketone bodies as an energy source and has shown effectiveness in treating drug-resistant epilepsy. Recent clinical and scientific knowledge supports its use for its anti-seizure efficacy, safety, and tolerability. It is also being explored as a potential treatment option for other neurological disorders.
BIOMEDICAL JOURNAL
(2022)
Article
Clinical Neurology
Mala Manral, Rekha Dwivedi, Sheffali Gulati, Kirandeep Kaur, Ashima Nehra, Ravindra Mohan Pandey, Ashish Datt Upadhyay, Savita Sapra, Manjari Tripathi
Summary: This study investigated whether Modified Atkins diet (MAD) combined with standard drug therapy (SDT) was more effective than SDT alone in reducing seizure frequency and improving psychological outcomes in adolescents and adults with drug-resistant epilepsy (DRE). The results showed that the MAD group had significant improvements in seizure frequency and behavioral problems compared to the control group.
Article
Behavioral Sciences
Irem Erkent, Fatma Ilgaz, Nese Dericioglu
Summary: This retrospective study analyzed adult patients with drug-resistant epilepsy who were offered and accepted ketogenic diet therapy (KDT) between 2014 and 2021. The study found that 91% of the patients failed to adhere to KDT, mainly due to inability to contact the dietitian, failure to implement correctly, inappropriate blood test results, and existing medical or surgical comorbidities. Strategies to improve compliance and minimize side effects are needed to increase the number of drug-refractory epilepsy patients who can benefit from this therapy.
EPILEPSY & BEHAVIOR
(2023)
Article
Medicine, Research & Experimental
Chunlong Mu, Naghmeh Nikpoor, Thomas A. Tompkins, Anamika Choudhary, Melinda Wang, Wendie N. Marks, Jong M. Rho, Morris H. Scantlebury, Jane Shearer
Summary: Targeted microbiota manipulation, mimicking changes induced by the ketogenic diet, reduces seizure frequency and improves locomotor activity in a rodent model of infantile spasms syndrome. This study suggests that microbiota manipulation could be a potential therapeutic avenue for pediatric epileptic encephalopathies.
Article
Nutrition & Dietetics
Francesca Felicia Operto, Angelo Labate, Salvatore Aiello, Cristina Perillo, Valeria de Simone, Rosetta Rinaldi, Giangennaro Coppola, Grazia Maria Giovanna Pastorino
Summary: The aim of this study was to evaluate parental stress after 6 and 12 months of a ketogenic diet, considering demographic and clinical variables. A standardized questionnaire was administered to assess parental stress. The results showed a significant increase in parental stress after 6 and 12 months of dietary treatment. Assessment of parental stress can help improve adherence to the ketogenic diet therapy.
Review
Nutrition & Dietetics
Kaleem Imdad, Turki Abualait, Ammara Kanwal, Ziyad Tareq AlGhannam, Shahab Bashir, Anum Farrukh, Sahir Hameed Khattak, Raidah Albaradie, Shahid Bashir
Summary: This article discusses the role of the ketogenic diet (KD) in the treatment of epilepsy, suggesting that ketone bodies can regulate neuronal metabolic activities, decrease seizure rate, and have significant therapeutic effects on epilepsy and related metabolic disorders.
Article
Medicine, General & Internal
Chunlong Mu, Naghmeh Nikpoor, Thomas A. Tompkins, Jong M. Rho, Morris H. Scantlebury, Jane Shearer
Summary: In this study using a rat model, it was found that infants with infantile spasms syndrome who were on a ketogenic diet (KD) had severe hepatic steatosis, which could be prevented by a specific probiotic blend. These probiotics protected the liver by improving signaling pathways and promoting lipid oxidation, potentially reducing the risk of hepatic side effects in children receiving KD treatment.
Article
Nutrition & Dietetics
Chunlong Mu, Angela Pochakom, Raylene A. Reimer, Anamika Choudhary, Melinda Wang, Jong M. Rho, Morris H. Scantlebury, Jane Shearer
Summary: The ketogenic diet is an effective treatment for infantile spasms syndrome. This study investigated the effect of adding a prebiotic fiber to the diet, and found that it improved metabolic parameters and gut microbiota diversity. However, it had no impact on spasms or developmental outcomes.
Article
Nutrition & Dietetics
Lenycia de Cassya Lopes Neri, Alexandre Archanjo Ferraro, Monica Guglielmetti, Simona Fiorini, Leticia Pereira de Brito Sampaio, Anna Tagliabue, Cinzia Ferraris
Summary: This study confirms the validity of Keto-check as an effective tool for assessing adherence to ketogenic dietary therapies. The effectiveness and adherence of dietary therapies are key to improving their outcomes, and understanding them better can lead to better healthcare approaches.