Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways

SiRNA-Mediated Flotillin-2 (Flot2) Downregulation Inhibits Cell Proliferation, Migration, and Invasion in Gastric Carcinoma Cells

(2014) Ke Cao et al.   ONCOLOGY RESEARCH

Increased Expression of Flotillin-2 Protein as a Novel Biomarker for Lymph Node Metastasis in Nasopharyngeal Carcinoma

(2014) Qiuyuan Wen et al.   PLoS One

Targeting Akt3 Signaling in Triple-Negative Breast Cancer

(2013) Y. R. Chin et al.   CANCER RESEARCH

Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model

(2013) Antje Banning et al.   CELLULAR SIGNALLING

Puerarin, isolated from Kudzu root (Willd.), attenuates hepatocellular cytotoxicity and regulates the GSK-3β/NF-κB pathway for exerting the hepatoprotection against chronic alcohol-induced liver injury in rats

(2013) Rong Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

DLC-1, a candidate tumor suppressor gene, inhibits the proliferation, migration and tumorigenicity of human nasopharyngeal carcinoma cells

(2013) XIANGLING FENG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Flotillin-2 is associated with breast cancer progression and poor survival outcomes

(2013) Xi Wang et al.   Journal of Translational Medicine

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Over-expression of BCAT1, a c-Myc target gene, induces cell proliferation, migration and invasion in nasopharyngeal carcinoma

(2013) Wen Zhou et al.   Molecular Cancer

Promoter hypermethylation along with LOH, but not mutation, contributes to inactivation ofDLC-1in nasopharyngeal carcinoma

(2013) Xiangling Feng et al.   MOLECULAR CARCINOGENESIS

Flotillin2 Expression Correlates with HER2 Levels and Poor Prognosis in Gastric Cancer

(2013) Zhi Zhu et al.   PLoS One

miR-122 Regulates Tumorigenesis in Hepatocellular Carcinoma by Targeting AKT3

(2013) Rounak Nassirpour et al.   PLoS One

Abnormal expression of FLOT1 correlates with tumor progression and poor survival in patients with non-small cell lung cancer

(2013) Hui Li et al.   TUMOR BIOLOGY

Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma

(2013) M Reis-Sobreiro et al.   Blood Cancer Journal

Matrix Metalloproteinases

(2012) Laurie A. Shuman Moss et al.   AMERICAN JOURNAL OF PATHOLOGY

Flotillin-1 Promotes Tumor Necrosis Factor-α Receptor Signaling and Activation of NF-κB in Esophageal Squamous Cell Carcinoma Cells

(2012) Libing Song et al.   GASTROENTEROLOGY

Flotillin-1/Reggie-2 Protein Plays Dual Role in Activation of Receptor-tyrosine Kinase/Mitogen-activated Protein Kinase Signaling

(2012) Monia Amaddii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model

(2012) T Berger et al.   ONCOGENE

Down regulation of E-Cadherin (ECAD) - a predictor for occult metastatic disease in sentinel node biopsy of early squamous cell carcinomas of the oral cavity and oropharynx

(2011) Gerhard F Huber et al.   BMC CANCER

Knockdown of FLOT1 Impairs Cell Proliferation and Tumorigenicity in Breast Cancer through Upregulation of FOXO3a

(2011) C. Lin et al.   CLINICAL CANCER RESEARCH

Lipid rafts: signaling and sorting platforms of cells and their roles in cancer

(2011) Simon Staubach et al.   Expert Review of Proteomics

Underlying mechanisms for LTF inactivation and its functional analysis in nasopharyngeal carcinoma cell lines

(2011) Hejun Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Interleukin 17A Promotes Hepatocellular Carcinoma Metastasis via NF-kB Induced Matrix Metalloproteinases 2 and 9 Expression

(2011) Jian Li et al.   PLoS One

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

Overexpressed HDGF as an independent prognostic factor is involved in poor prognosis in Chinese patients with liver cancer

(2010) Yanyan Zhou et al.   Diagnostic Pathology

Loss of RhoB Expression Promotes Migration and Invasion of Human Bronchial Cells Via Activation of AKT1

(2009) E. Bousquet et al.   CANCER RESEARCH

Targeting Akt3 Signaling in Malignant Melanoma Using Isoselenocyanates

(2009) A. Sharma et al.   CLINICAL CANCER RESEARCH

Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells

(2009) Kyoung-Ok Hong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations

(2008) J LOPICCOLO et al.   DRUG RESISTANCE UPDATES