Article
Hematology
Enyong Su, Peng Yu, Baoli Zhang, Anjing Zhang, Shiyao Xie, Chunyu Zhang, Su Li, Yunzeng Zou, Ming Liu, Hong Jiang, Junbo Ge
Summary: This study discovered that ANG exerts a protective effect against atherosclerosis by regulating ER stress through ST3GAL5. Deficiency of endothelial ANG aggravates ER stress and adhesion molecule expression, leading to exacerbation of atherosclerotic lesions.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biology
Guangfeng Geng, Jinhua Liu, Changlu Xu, Yandong Pei, Linbo Chen, Chenglong Mu, Ding Wang, Jie Gao, Yue Li, Jing Liang, Tian Zhao, Chuanmei Zhang, Jiaxi Zhou, Quan Chen, Yushan Zhu, Lihong Shi
Summary: Erythropoietin (EPO) is crucial for erythropoiesis, and mitochondrial quality control, specifically through the mitophagy receptor FUNDC1, plays a significant role in EPO-driven erythropoiesis. Impaired FUNDC1 function leads to the accumulation of damaged mitochondria, elevated ROS levels, inflammatory responses, and decreased EPO production in renal anemia. This study suggests that targeting mitochondrial quality control mechanisms could be a potential therapeutic strategy for treating renal anemia.
Article
Cell Biology
Xiaofan Yang, Pingping Xue, Meng Yuan, Xiang Xu, Cheng Wang, Wenqing Li, Hans-Guenther Machens, Zhenbing Chen
Summary: The study showed that after denervation of skeletal muscles, the stress-induced protein SESN2 was induced to regulate endoplasmic reticulum stress, mitochondrial dysfunction, and apoptosis, and its increase can protect against severe atrophy by inhibiting protein synthesis and promoting mitophagy.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Hui Jiang, Cong Wang, An Zhang, Yufeng Li, Jianping Li, Zhan Li, Xin Yang, Yinglong Hou
Summary: The cardiotoxicity of Sorafenib is associated with the ferroptosis of cardiomyocytes. Activation of endoplasmic reticulum stress and the unfolded protein response might be attributed to lipid reactive oxygen species-mediated perturbation of the endoplasmic reticulum. ATF4 promotes cardiomyocyte survival by up-regulation of SLC7A11 and suppression of ferroptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Heba Abdelazeem, Ly Tu, Raphael Thuillet, Mina Ottaviani, Achraf Boulfrad, Thomas Beck, Amira Senbel, Salma Mani, Yves Castier, Alice Guyard, Alexy Tran-Dinh, Jamel El-Benna, Dan Longrois, Adam M. Silverstein, Christophe Guignabert, Xavier Norel
Summary: The study found that metformin treatment can slow down the progression of monocrotaline-induced pulmonary hypertension in rats and protect lung tissue by increasing endothelial nitric oxide synthase activity and protein kinase G-1 expression. In addition, AMPK activation can reduce vasoconstriction in patients with pulmonary hypertension. This study suggests that AMPK activation can enhance the nitric oxide pathway, alleviate vasoconstriction through direct effects on smooth muscles, and reverse pulmonary hypertension in rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Ying Lu, Shou-ye Li, Hui Lou
Summary: Patchouli alcohol (PA) protects against myocardial ischemia/reperfusion (MI/R) injury by modulating endoplasmic reticulum stress, apoptosis, and the Notch1/Hes1 signaling pathway. These findings suggest that PA may be a potential drug for treating ischemic heart diseases.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Li-xue Wang, Chao Ren, Ren-qi Yao, Yi-nan Luo, Yue Yin, Yao Wu, Ning Dong, Xiao-mei Zhu, Yong-ming Yao
Summary: SESN2 plays a crucial role in sepsis by inhibiting NLRP3 inflammasome hyperactivation, reducing CASP-1-dependent pyroptosis, and improving sepsis outcomes. Lack of SESN2 leads to increased inflammatory response and higher mortality.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Xiaofei Zhou, Yuanqing Jiang, Yuewen Wang, Linge Fan, Yunhui Zhu, Yefeng Chen, Yiran Wang, Yingyi Zhu, Hongkun Wang, Zihang Pan, Zhoubin Li, Xiaolong Zhu, Ruizhe Ren, Zhen Ge, Dongwu Lai, En Yin Lai, Ting Chen, Kai Wang, Ping Liang, Lingfeng Qin, Cuiqing Liu, Cong Qiu, Michael Simons, Luyang Yu
Summary: This study found that the FIS1 protein in endothelial mitochondria undergoes a transition between SUMOylation and deSUMOylation in hypoxia-induced pulmonary hypertension (PH). Short-term hypoxia promotes the translocation of SENP1 to endothelial mitochondria and deSUMOylation of FIS1, maintaining mitochondrial integrity and calcium communication. Prolonged hypoxia inhibits this process, leading to mitochondrial dysfunction and metabolic reprogramming.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Anna Kowalczuk, Krzysztof Marycz, Justyna Kornicka, Sylwia Groborz, Justyna Meissner, Malwina Mularczyk
Summary: In this study, the protective effects of THCV isolated from Cannabis sativa L. against ER stress in adipose-derived mesenchymal stem cells were evaluated. It was found that THCV can prevent subcellular alterations, restore cell functions upon ER stress, and decrease the expression of genes involved in the UPR pathway. These findings suggest that THCV has potential as a therapeutic compound for metabolic diseases associated with ER stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Biswajit Padhy, Jian Xie, Runping Wang, Fang Lin, Chou-Long Huang
Summary: Polycystin-2 in the endoplasmic reticulum plays a critical role in the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) by acting as a potassium ion channel and facilitating the exchange of potassium and calcium ions. This study provides a deeper understanding of ADPKD and suggests that TRIC-B activators could be used as a potential pharmacotherapy.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Pharmacology & Pharmacy
Kumru Turhan, Elif Alan, Gunay Yetik-Anacak, Gulnur Sevin
Summary: Pulmonary arterial hypertension is caused by complex changes in the endothelial and smooth muscle cells of pulmonary arteries. Hydrogen sulfide (H2S) has potential to treat this condition by relaxing the arteries and reducing pressure. This study found that H2S levels were decreased and endothelium-dependent vasorelaxation was impaired in monocrotaline-induced pulmonary arterial hypertension. However, treatment with the H2S donor, Na2S, prevented endothelial dysfunction, increased artery pressure, and restored H2S levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Philma Glora Muthuraj, Aryamav Pattnaik, Prakash K. Sahoo, Md Torikul Islam, Asit K. Pattnaik, Siddappa N. Byrareddy, Corrine Hanson, Ann Anderson Berry, Stephen D. Kachman, Sathish Kumar Natarajan
Summary: Studies have shown that omega-7 monounsaturated fatty acid protects placental trophoblasts against Zika virus-induced endoplasmic reticulum stress and apoptosis.
Article
Pharmacology & Pharmacy
Hanwen Liu, Yanwen Li, Maogang Li, Linghai Xie, Feng Li, Runmei Pan, Fang Pei
Summary: The results suggest that FSTL1 prevents endothelial dysfunction in mesenteric arteries of SHRs through inhibiting ER stress and ROS and increasing NO production via activation of AMPK signaling. FSTL1 treatment reversed several abnormal physiological markers in mesenteric arteries of SHRs.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Biochemistry & Molecular Biology
Yan Zhou, Yuehan Wang, Chi Teng Vong, Yanyan Zhu, Baojun Xu, Cheng-Chao Ruan, Yitao Wang, Wai San Cheang
Summary: JAT has vasoprotective effects in diabetes and obesity by enhancing the Akt/eNOS pathway and NO bioavailability, as well as suppressing ER stress and oxidative stress to improve endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Matshediso Zachariah, Hatem Maamoun, Larissa Milano, Margaret P. Rayman, Lisiane B. Meira, Abdelali Agouni
Summary: Selenium is an essential trace element for human health, but a balanced intake is crucial for maximizing its health benefits. High selenium intake above physiological levels may increase diabetes risk and result in endothelial dysfunction. Selenium induces cancer cell apoptosis via endoplasmic reticulum stress, but its role in endothelial dysfunction remains unknown.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chak Kwong Cheng, Xiao Lin, Yujie Pu, Joyce Ka Yu Tse, Yu Wang, Cheng-Lin Zhang, Xiaoyun Cao, Chi Wai Lau, Juan Huang, Lei He, Jiang-Yun Luo, Yu-Tsung Shih, Song Wan, Chi Fai Ng, Li Wang, Ronald Ching Wan, Jeng-Jiann Chiu, Ting Fung Chan, Xiao Yu Tian, Yu Huang
Summary: This study utilized single-cell RNA sequencing to explore the transcriptional landscape and heterogeneity of dysfunctional endothelial cells in atherosclerotic aortae. SOX4 was identified as a novel marker for atherosclerosis and was shown to promote atherogenesis and endothelial-to-mesenchymal transition. Hyperlipidemia-associated cytokines and oscillatory blood flow were found to upregulate SOX4 expression, while the anti-diabetic drug metformin suppressed SOX4 levels in endothelial cells.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Huanyu Ding, Minchun Jiang, Chi Wai Lau, Jianfang Luo, Andrew M. M. Chan, Li Wang, Yu Huang
Summary: YAP inhibition by CBL0137 is a promising therapeutic approach for atherosclerotic vascular disease.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Jeffrey Shi Kai Chan, Danish Iltaf Satti, Yan Hiu Athena Lee, Khalid Bin Waleed, Pias Tang, Gauranga Mahalwar, Abdul Mannan Khan Minhas, Leonardo Roever, Giuseppe Biondi-Zoccai, Fung Ping Leung, Wing Tak Wong, Tong Liu, Jiandong Zhou, Gary Tse
Summary: The variability of LDL-C, HDL-C, TC, and TG is associated with an increased risk of incident cancer. Patients with higher variability in these lipids have a higher risk of developing cancer.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Jeffrey Shi Kai Chan, Ishan Lakhani, Teddy Tai Loy Lee, Oscar Hou In Chou, Yan Hiu Athena Lee, Yiu Ming Cheung, Hoi Wa Yeung, Pias Tang, Kenrick Ng, Edward Christopher Dee, Tong Liu, Wing Tak Wong, Gary Tse, Fung Ping Leung
Summary: This retrospective cohort study examined the associations between immune checkpoint inhibitors (ICI) and adverse cardiovascular events in Asian users. The results showed that MACE and cardiovascular hospitalization rates were highest during the first year after initiating ICI. Compared to non-Asian users, Asian users had a lower incidence of MACE and a smaller proportion of cardiovascular-related hospitalizations.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Sharen Lee, Cheuk To Chung, Oscar Hou In Chou, Teddy Tai Loy Lee, Danny Radford, Kamalan Jeevaratnam, Wing Tak Wong, Shuk Han Cheng, Ngai Shing Mok, Tong Liu, Gary Tse
Summary: Understanding the utilization of healthcare resources and its associated costs is crucial for improving resource allocation, but little research has been conducted on this issue in the setting of Brugada syndrome (BrS). In this retrospective study of BrS patients in Hong Kong, the healthcare resource utilization for accident and emergency, inpatient, and specialist outpatient visits was analyzed over 19 years. The median annual costs were $110 for accident and emergency visits, $6812 for inpatient stays, and $557 for specialist outpatient visits.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Neurosciences
Oscar Hou In Chou, Jiandong Zhou, Lifang Li, Jeffrey Shi Kai Chan, Danish Iltaf Satti, Vanessa Hou Cheng Chou, Wing Tak Wong, Sharen Lee, Bernard Man Yung Cheung, Gary Tse, Carlin Chang, Tong Liu
Summary: This retrospective population-based cohort study aimed to explore the association between neutrophil-to-lymphocyte ratio (NLR) and dementia. The results showed that patients with NLR >5.44 had an increased risk of developing Alzheimer's disease and related dementia, but not non-Alzheimer's dementia. Utilizing baseline NLR during family medicine consultation may help predict the risks of dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Oncology
Cheuk To Chung, Ishan Lakhani, Oscar Hou In Chou, Teddy Tai Loy Lee, Christopher Dee, Kendrick Ng, Wing Tak Wong, Tong Liu, Sharen Lee, Qingpeng Zhang, Bernard Man Yung Cheung, Gary Tse, Jiandong Zhou
Summary: According to this cohort study, SGLT2I use was associated with lower risks of all-cause mortality, cancer-related mortality, and new-onset overall cancer compared to DPP4I use. Furthermore, SGLT2I use was also linked to a decreased risk of new-onset breast cancer.
Article
Biochemistry & Molecular Biology
Chak Kwong Cheng, Huanyu Ding, Minchun Jiang, Huiyong Yin, Maik Gollasch, Yu Huang
Summary: Perivascular adipose tissue (PVAT) refers to the aggregate of adipose tissue surrounding the vasculature, exhibiting the phenotypes of white, beige and brown adipocytes. PVAT is actively involved in the regulation of reactive oxygen species (ROS) homeostasis and inflammation in the vascular system. The phenotype-genotype of PVAT varies in different regions of the vasculature and plays a role in cardiovascular pathogenesis. Treatments targeting PVAT may provide new therapeutic insights for cardiovascular diseases.
Article
Oncology
Salman Ahmed, Waqas Alam, Michael Aschner, Rosanna Filosa, Wai San Cheang, Philippe Jeandet, Luciano Saso, Haroon Khan
Summary: Neuroblastoma is a common solid tumor in pediatric patients that arises from sympathetic nervous system cells. Current treatments have limited success, leading to high mortality and relapse rates. Marine cyanobacteria, which contain bioactive metabolites, have shown promise as alternative treatments. This review focuses on the anticancer effects of cyanobacterial peptides against neuroblastoma. Marine peptides offer advantages such as small size, easy manufacturing, ability to cross cell membranes, minimal drug interactions, little impact on the blood-brain barrier, and targeting capabilities. The review discusses the cytotoxic effects of cyanobacterial peptides, including apoptosis, caspase activation, cell cycle arrest, sodium channel blocking, autophagy, and anti-metastasis properties.
Review
Cell Biology
Yiu-Ming Cheung, Chui-Yiu-Bamboo Chook, Hoi-Wa Yeung, Fung-Ping Leung, Wing-Tak Wong
Summary: Progress has been made in identifying stem cell aging as a pathological manifestation of a variety of diseases, including obesity. Adipose stem cells (ASCs) play a core role in adipocyte turnover, which maintains tissue homeostasis. Given aberrant lineage determination as a feature of stem cell aging, failure in adipogenesis is a culprit of adipose hypertrophy, resulting in adiposopathy and related complications.
Article
Nutrition & Dietetics
Chui Yiu Bamboo Chook, Yiu Ming Cheung, Ka Ying Ma, Fung Ping Leung, Hanyue Zhu, Qingshan Jason Niu, Wing Tak Wong, Zhen-Yu Chen
Summary: Research found that cardiovascular diseases are the leading cause of death in type 2 diabetes, and current diabetic medications have limited effects on cardiovascular mortality. Experiments on mouse aortas showed that protocatechuic acid (PCA) can improve endothelial function and has antioxidant and anti-inflammatory effects. The protection on cardiovascular function is exerted through the Akt/eNOS pathway. Therefore, it is recommended for diabetic patients to consume an appropriate amount of PCA daily.
FRONTIERS IN NUTRITION
(2023)
Article
Cell Biology
Huixian Li, Chufeng He, Ruiwen Zhu, Francis M. Chen, Lin Wang, Fung Ping Leung, Xiao Yu Tian, Gary Tse, Wing Tak Wong
Summary: This study reveals that interleukin-4 (IL-4) and interleukin-13 (IL-13) play a critical role in post-ischemic angiogenesis. Deficiency of IL-4/IL-13 leads to impaired reperfusion and muscle repair in ischemic muscles. Mechanistically, IL-4/IL-13 promote endothelial cell proliferation, migration, and tube formation through the IL-4Ra/STAT6 signaling pathway. Additionally, decreased expression of IL-4/IL-13 is associated with angiogenesis deficit in diabetic peripheral arterial disease (PAD), while IL-4/IL-13 treatment can rescue this defective regeneration.
Article
Food Science & Technology
Yuting Chen, Yujuan Xu, Jing Wen, Yuanshan Yu, Jijun Wu, Lina Cheng, Wai-San Cheang, Wenwen Liu, Manqin Fu
Summary: This study conducted metabolic analysis to compare the metabolites of Citrus reticulata 'Chachi' peel at different harvesting periods. A total of 168 flavonoid metabolites were identified, and their relative contents showed variations throughout the months.
Article
Chemistry, Multidisciplinary
Wing-Fu Lai, Obireddy Sreekanth Reddy, Lucy Law, Haicui Wu, Wing-Tak Wong
Summary: In this study, a crosslinked blended hydrogel was generated using gelatine and chitosan with clusteroluminogenic properties, which not only exhibited intrinsic antibacterial properties and high tunability in delivery performance but also had a self-indicating capacity for quality control during hydrogel preparation. The release profiles of the agent-loaded gels followed the Higuchi model well, with the non-Fickian mechanism being the major mechanism of the release process. Our gels have high efficiency in agent loading and have great potential in bioactive agent delivery and related biomedical applications.
Article
Sport Sciences
Chen Zheng, Jason M. R. Gill, Feng Hua Sun, Wendy Yajun Huang, Sinead Sheridan, Xiang-Ke Chen, Yalan Wu, Chun-Kwok Wong, Xiao Yu Tian, Stephen Heung-Sang Wong
Summary: Increasing daily physical activity is an effective way to reduce the risk of cardiometabolic diseases. This study compared the effects of increasing light physical activity (LPA) and moderate-to-vigorous physical activity (MVPA) on cardiometabolic markers in Chinese adults with obesity. The results showed that MVPA had more positive effects on body composition and cardiometabolic biomarkers compared to LPA.
JOURNAL OF SPORTS SCIENCES
(2023)